Abstract:
:The hypothesis that reactive free radical species (ROS) may contribute to the pathogenesis of Duchenne muscular dystrophy (DMD) has been suggested previously, but experimental data obtained in support of the above have to date proved inconclusive. The recent discovery that nitric oxide synthase (required for muscle relaxation) is associated with the sarcolemmal protein dystrophin normally and that both proteins are absent in DMD has heightened interest in the potential role of ROS in this disorder. We therefore investigated oxidative damage to proteins in the quadriceps femoris muscle by quantifying protein carbonyl levels in six patients with DMD and six normal controls. In DMD, the mean protein carbonyl level in the quadriceps femoris muscle was increased by 211% (p < 0.005) compared with the normal control subjects. The data thus support the hypothesis for the role of ROS induced protein oxidation of muscle cell damage in DMD.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Haycock JW,MacNeil S,Jones P,Harris JB,Mantle Ddoi
10.1097/00001756-199612200-00070subject
Has Abstractpub_date
1996-12-20 00:00:00pages
357-61issue
1eissn
0959-4965issn
1473-558Xjournal_volume
8pub_type
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