Oxidative damage to muscle protein in Duchenne muscular dystrophy.


:The hypothesis that reactive free radical species (ROS) may contribute to the pathogenesis of Duchenne muscular dystrophy (DMD) has been suggested previously, but experimental data obtained in support of the above have to date proved inconclusive. The recent discovery that nitric oxide synthase (required for muscle relaxation) is associated with the sarcolemmal protein dystrophin normally and that both proteins are absent in DMD has heightened interest in the potential role of ROS in this disorder. We therefore investigated oxidative damage to proteins in the quadriceps femoris muscle by quantifying protein carbonyl levels in six patients with DMD and six normal controls. In DMD, the mean protein carbonyl level in the quadriceps femoris muscle was increased by 211% (p < 0.005) compared with the normal control subjects. The data thus support the hypothesis for the role of ROS induced protein oxidation of muscle cell damage in DMD.






Haycock JW,MacNeil S,Jones P,Harris JB,Mantle D




Has Abstract


1996-12-20 00:00:00












  • Voice onset time encoding in patients with left and right cochlear implants.

    abstract::Stop-consonant discrimination was investigated in normal-hearing listeners and cochlear-implanted patients (CIP) by recording auditory evoked potentials (AEPs) to /b epsilon/ and /p epsilon/ syllables. This study demonstrates that: (i) AEPs show time-locked components that mimic the temporal structure of the stimuli, ...


    pub_type: 杂志文章


    authors: Roman S,Canévet G,Lorenzi C,Triglia JM,Liégeois-Chauvel C

    更新日期:2004-03-22 00:00:00

  • Serotonin transporters are preserved in the neocortex of anxious Alzheimer's disease patients.

    abstract::Densities of serotonin transporters (5-HTT) in the postmortem neocortex of behaviorally assessed Alzheimer's disease (AD) patients and aged controls were measured by radioligand binding with [3H]citalopram. It was found that 5-HTT sites in the temporal cortex of AD patients with prominent antemortem anxiety were unalt...


    pub_type: 杂志文章


    authors: Tsang SW,Lai MK,Francis PT,Wong PT,Spence I,Esiri MM,Keene J,Hope T,Chen CP

    更新日期:2003-07-18 00:00:00

  • Correlation between food intake and CSF IL-1 alpha in anorectic tumor bearing rats.

    abstract::Postulating that central IL-1 is involved in the pathogenesis of cancer anorexia we measured IL-1 alpha in cerebrospinal fluid (CSF) from anorectic tumor bearing (TB) rats and non-tumor bearing controls, and correlated their CSF IL-1 alpha with food intake and tumor weight. Food intake in controls was significantly hi...


    pub_type: 杂志文章


    authors: Opara EI,Laviano A,Meguid MM,Yang ZJ

    更新日期:1995-03-27 00:00:00

  • Reproductive senescence predicts cognitive decline in aged female monkeys.

    abstract::The present investigation provide evidences from a non-human primate model that naturally occurring menopause predicts a prominent signature of age-related cognitive decline. Young and aged rhesus monkeys were tested on a delayed response (DR) task known to the sensitive to aging, and reproductive status was evaluated...


    pub_type: 杂志文章


    authors: Roberts JA,Gilardi KV,Lasley B,Rapp PR

    更新日期:1997-05-27 00:00:00

  • Distribution of basal-expressed c-fos-like immunoreactive cells of the periaqueductal grey matter of the rat.

    abstract::The distribution of c-fos proto-oncogene expression has been studied in the periaqueductal grey matter (PAG) of non-intentional-stimulated rats by immunohistochemistry. A mean number of 53 +/- 9 Fos-like immunoreactive cells per hemiPAG, distributed into three groups, dorsolateral, lateral and ventrolateral, was found...


    pub_type: 杂志文章


    authors: Valverde-Navarro AA,Olucha FE,García-Verdugo JM,Hernández-Gil T,Ruiz-Torner A,Martínez-Soriano F

    更新日期:1996-11-04 00:00:00

  • Functional anatomy on perception of position and motion in depth.

    abstract::To investigate the neural substrates for the perception of motion and of position in depth, we examined the changes in regional cerebral blood flow during positional and motion stereopsis in humans by positron emission tomography. During positional stereopsis, the right striate and peristriate cortices (areas V1/V2 an...


    pub_type: 杂志文章


    authors: Nagahama Y,Takayama Y,Fukuyama H,Yamauchi H,Matsuzaki S,Magata Y,Shibasaki H,Kimura J

    更新日期:1996-07-29 00:00:00

  • Long-lasting effects of chemical hypoxia on spinal cord function in tadpoles.

    abstract::We investigated the effects of chemical hypoxia on the central pattern generator controlling swimming in stage 42 Xenopus laevis larvae. We recorded motoneuron activity from ventral roots of immobilized tadpoles and evoked swim episodes by brief electrical stimulation of the tail skin. In the presence of the metabolic...


    pub_type: 杂志文章


    authors: Robertson RM,Björnfors ER,Sillar KT

    更新日期:2010-10-06 00:00:00

  • Fate of adult neural precursors grafted to adult cortex monitored with a Y-chromosome marker.

    abstract::Freshly dissected and dissociated subventricular zone cells from adult male mice were transplanted into the right cerebral cortex of adult female mice. Host mice were perfused 3 or 7 weeks later. To detect donor male cells, paraffin sections (10 microm) were hybridized in situ with a Y-chromosome-specific probe. Some ...


    pub_type: 杂志文章


    authors: Harvey AR,Symons NA,Pollett MA,Brooker GJ,Bartlett PF

    更新日期:1997-12-22 00:00:00

  • Effects of movement on somatosensory N20m fields and high-frequency oscillations.

    abstract::Somatosensory evoked fields were recorded to determine the effects of movement and attention on high-frequency oscillations during active finger movements of the ipsilateral and contralateral sides in response to electrical stimulation of the median nerve. A whole-scalp neuromagnetometer was used to record somatosenso...


    pub_type: 杂志文章


    authors: Inoue K,Harada T,Kaseda Y,Mimori Y,Hashizume A,Hashimoto I,Matsumoto M

    更新日期:2002-10-28 00:00:00

  • Primary auditory cortex activation by visual speech: an fMRI study at 3 T.

    abstract::Recent studies have yielded contradictory evidence on whether visual speech perception (watching articulatory gestures) can activate the human primary auditory cortex. To circumvent confounds due to inter-individual anatomical variation, we defined our subjects' Heschl's gyri and assessed blood oxygenation-dependent s...


    pub_type: 杂志文章


    authors: Pekkola J,Ojanen V,Autti T,Jääskeläinen IP,Möttönen R,Tarkiainen A,Sams M

    更新日期:2005-02-08 00:00:00

  • Processing of presenilin 1 in brains of patients with Alzheimer's disease and controls.

    abstract::Mutations in the presenilin genes are involved in the aetiology of the majority of familial early-onset Alzheimer disease (AD) cases. Presenilin 1 (PS1) is proteolytically processed in vivo, resulting in the accumulation of N-terminal approximately 27-28 kDa and C-terminal approximately 18 kDa derivatives. To examine ...


    pub_type: 杂志文章


    authors: Hendriks L,Thinakaran G,Harris CL,De Jonghe C,Martin JJ,Sisodia SS,Van Broeckhoven C

    更新日期:1997-05-06 00:00:00

  • A novel method of organotypic spinal cord slice culture in rats.

    abstract::This study was undertaken to establish a method for the culture of organotypic spinal cord slices. A long-term organotypic spinal cord slice culture was conducted from postnatal rats. Lumbar spinal cord was isolated, and meninges were removed from the spinal cord. The spinal cord was embedded in 4% agarose, and was se...


    pub_type: 杂志文章


    authors: Liu JJ,Huang YJ,Xiang L,Zhao F,Huang SL

    更新日期:2017-11-08 00:00:00

  • Atypical temporal lobe language representation: MEG and intraoperative stimulation mapping correlation.

    abstract::Functional brain imaging techniques hold many promises as the methods of choice for identifying areas involved in the execution of language functions. The success of any of these techniques in fulfilling this goal depends upon their ability to produce maps of activated areas that overlap with those obtained through st...


    pub_type: 杂志文章


    authors: Simos PG,Breier JI,Maggio WW,Gormley WB,Zouridakis G,Willmore LJ,Wheless JW,Constantinou JE,Papanicolaou AC

    更新日期:1999-01-18 00:00:00

  • Improved fluorophore separation with IMS confocal microscopy.

    abstract::Some of the most extensively used fluorophores for multicolour fluorescence labelling of tissue, such as Lucifer yellow, fluorescein, Cyanine-3.18 and rhodamine, all have the disadvantage of being difficult to separate spectrally due to their broad and overlapping emission spectra. With the intensity-modulated multipl...


    pub_type: 杂志文章


    authors: Carlsson K,Ulfhake B

    更新日期:1995-05-30 00:00:00

  • Ca(2+)-sensitive and insensitive omega-conotoxin GVIA binding sites in rat brain.

    abstract::The autoradiographic distribution of Ca(2+)-sensitive high- and low-affinity binding sites for the N-type calcium channel ligand, [125I]omega-conotoxin GVIA, has been examined in rat brain. Both classes of sites were rather evenly distributed, exhibiting their highest density in cell body rich layers, such as the pyra...


    pub_type: 杂志文章


    authors: Vandaele SF,Reader TA

    更新日期:1994-05-09 00:00:00

  • Functional imaging of brain activity in conscious monkeys responding to sexually arousing cues.

    abstract::Olfactory cues can elicit intense emotional responses. This study used fMRI in male common marmoset monkeys to identify brain areas associated with sexual arousal in response to odors of ovulating female monkeys. Under light anesthesia, monkeys were secured in a specially designed restrainer and positioned in a 9.4 T ...


    pub_type: 杂志文章


    authors: Ferris CF,Snowdon CT,King JA,Duong TQ,Ziegler TE,Ugurbil K,Ludwig R,Schultz-Darken NJ,Wu Z,Olson DP,Sullivan JM Jr,Tannenbaum PL,Vaughan JT

    更新日期:2001-07-20 00:00:00

  • Timbre-specific enhancement of auditory cortical representations in musicians.

    abstract::Neural imaging studies have shown that the brains of skilled musicians respond differently to musical stimuli than do the brains of non-musicians, particularly for musicians who commenced practice at an early age. Whether brain attributes related to musical skill are attributable to musical practice or are hereditary ...


    pub_type: 杂志文章


    authors: Pantev C,Roberts LE,Schulz M,Engelien A,Ross B

    更新日期:2001-01-22 00:00:00

  • Role of Gq alpha in insulin-stimulated glucose uptake by C6 glioma cells.

    abstract::To investigate the possibility that insulin-stimulated glucose uptake in C6 cells is due to transactivation of a G protein-mediated pathway, the role of Gq alpha in insulin signaling was studied. Insulin stimulation of [3H]2-deoxy-D-glucose (2DG) uptake by C6 cells was time- and concentration-dependent: at a concentra...


    pub_type: 杂志文章


    authors: Singh SP,Gao Y,Kunapuli SP,Ravindra R

    更新日期:1997-07-07 00:00:00

  • MK-801 decreases striatal and cortical GAD65 mRNA levels.

    abstract::Levels of mRNAs encoding for the two isoforms of glutamate decarboxylase, GAD67 and GAD65, were quantified in the rat striatum and cerebral cortex following single injections of the non-competitive NMDA receptor antagonist MK-801. Acute MK-801 induced a dose-dependent decrease in GAD65 mRNA levels in ventral sectors o...


    pub_type: 杂志文章


    authors: Laprade N,Soghomonian JJ

    更新日期:1995-10-02 00:00:00

  • Moyamoya patients exhibit higher brain temperatures than normal controls.

    abstract::The balance between heat production (metabolism) and heat removal (blood flow) helps in keeping the temperature of the brain constant. In patients with moyamoya disease, this balance may be disturbed. The purpose of this study was to assess the thermal pathophysiology of the brain in patients with moyamoya disease. Th...


    pub_type: 杂志文章


    authors: Yamada K,Sakai K,Akazawa K,Yuen S,Sugimoto N,Sasajima H,Mineura K,Nishimura T

    更新日期:2010-09-15 00:00:00

  • Temporal prediction restores the evaluative processing of delayed action feedback: an electrophysiological study.

    abstract::The evaluative processing of the valence of action feedback is reflected by an event-related brain potential component called feedback-related negativity (FRN) or reward positivity (RewP). Recent studies have shown that FRN/RewP is markedly reduced when the action-feedback interval is long (e.g. 6000 ms), indicating t...


    pub_type: 杂志文章


    authors: Kimura K,Kimura M

    更新日期:2016-09-28 00:00:00

  • Serotonin-6 receptor variant (C267T) and clinical response to clozapine.

    abstract::Clozapine is an effective atypical antipsychotic that has high affinity for serotonin type 6 receptors (5HT6). We tested the hypothesis that clinical response to clozapine in patients refractory to typical antipsychotic treatment is related to the genetic variant (C267T) of the 5HT6 receptors. Ninety-nine schizophreni...


    pub_type: 杂志文章


    authors: Yu YW,Tsai SJ,Lin CH,Hsu CP,Yang KH,Hong CJ

    更新日期:1999-04-26 00:00:00

  • Acute marijuana effects on rCBF and cognition: a PET study.

    abstract::The effects of smoking marijuana on cognition and brain function were assessed with PET using H2(15)O. Regional cerebral blood flow (rCBF) was measured in five recreational users before and after smoking a marijuana cigarette, as they repeatedly performed an auditory attention task. Blood flow increased following smok...


    pub_type: 临床试验,杂志文章


    authors: O'Leary DS,Block RI,Flaum M,Schultz SK,Boles Ponto LL,Watkins GL,Hurtig RR,Andreasen NC,Hichwa RD

    更新日期:2000-11-27 00:00:00

  • Increased sensitivity to ET-1 in rat cerebral arteries following organ culture.

    abstract::Endothelin-1 (ET-1) is recognized as being involved in the pathophysiology of cerebrovascular diseases. Using organ culture as a model for possible pathological changes we studied changes in ET(A) and ETB receptor function using a sensitive in vitro method. We observed an up-regulation of the ET(B) receptor and an ama...


    pub_type: 杂志文章


    authors: Hansen-Schwartz J,Edvinsson L

    更新日期:2000-02-28 00:00:00

  • Diversity of aquaporin mRNA expressed by rat and human retinas.

    abstract::Muller glial cells of the sensory retina mediate K+ and water fluxes that are facilitated by aquaporin-4 (AQP4) water channels and by Kir4.1-K+ channels. However, it is not known which subtypes of aquaporins are expressed in the mammalian retina. Using RT-PCR, we found that both human and rat retinas express mRNA for ...


    pub_type: 杂志文章


    authors: Tenckhoff S,Hollborn M,Kohen L,Wolf S,Wiedemann P,Bringmann A

    更新日期:2005-01-19 00:00:00

  • A simulated actuator driven by motor cortical signals.

    abstract::One problem in motor control concerns the mechanism whereby the central nervous system translates the motor cortical command encoded in cell activity into a coordinated contraction of limb muscles to generate a desired motor output. This problem is closely related to the design of adaptive systems that transform neuro...


    pub_type: 杂志文章


    authors: Lukashin AV,Amirikian BR,Georgopoulos AP

    更新日期:1996-11-04 00:00:00

  • Loss feedback negativity elicited by single- versus conjoined-feature stimuli.

    abstract::Event-related brain potential studies show that negative feedback in guessing tasks elicits a medial frontal negativity. Most theory and experimentation concerning this feedback-related negativity (FRN) has assumed that the FRN has little relationship to the perceptual characteristics of the feedback. This study chall...


    pub_type: 杂志文章


    authors: Liu Y,Gehring WJ

    更新日期:2009-04-22 00:00:00

  • Psychophysical evidence for a general temporal processing deficit in children with dyslexia.

    abstract::The hypothesis of a general (i.e. cross-modal) temporal processing deficit in dyslexia was tested by examining rapid processing in both the auditory and the visual system in the same children with dyslexia. Participants were 10- to 12-year-old dyslexic readers and age-matched normal reading controls. Psychophysical th...


    pub_type: 杂志文章


    authors: Van Ingelghem M,van Wieringen A,Wouters J,Vandenbussche E,Onghena P,Ghesquière P

    更新日期:2001-11-16 00:00:00

  • Immunolocalization of two cytochrome P450 isozymes in rat nasal chemosensory tissue.

    abstract::The NMa and NMb isoforms of cytochrome P450 enzymes are expressed in three nasal chemosensory organs: the olfactory, septal and vomeronasal mucosae. The NMa isoform is widely distributed throughout the nasal mucosa whereas the NMb isoform is present primarily in the chemosensory mucosae. The localization of cytochrome...


    pub_type: 杂志文章


    authors: Chen Y,Getchell ML,Ding X,Getchell TV

    更新日期:1992-09-01 00:00:00

  • Gamma frequency band shift of contralateral corticomuscular synchronous oscillations with force strength for hand movement tasks.

    abstract::Bilateral voluntary contractions involve functional changes in both primary motor cortices. However how the unilateral voluntary contraction of hand muscles influences the contralateral corticomuscular synchronous oscillations mechanisms remains unclear. In the bimanual tasks, nine healthy subjects were instructed to ...


    pub_type: 杂志文章


    authors: Li S,Fan M,Yu H,Gao L

    更新日期:2020-03-04 00:00:00