Oxidative damage to muscle protein in Duchenne muscular dystrophy.

abstract：:We report an event-related potential study investigating the neural basis of interference and facilitation in the picture-word interference paradigm with immediate overt naming. We used the high temporal resolution of the electrophysiological response to dissociate general and specific interference processes, by compa...

journal_title：Neuroreport

authors： Hirschfeld G,Jansma B,Bölte J,Zwitserlood P

更新日期：2008-08-06 00:00:00

abstract：:Neural plasticity in the visual cortex, as tested by changes in its functional organization induced by monocular deprivation (MD), is present only during a restricted period of postnatal development (critical period). To investigate whether this process of synapse strengthening depends upon NGF, we antagonized endogen...

journal_title：Neuroreport

authors： Domenici L,Cellerino A,Berardi N,Cattaneo A,Maffei L

更新日期：1994-10-27 00:00:00

abstract：:N- and C-terminal substance P (SP) fragments increase striatal dopamine outflow at nanomolar concentrations. This contrasts with their low affinity for NK1 receptors. To explore this discrepancy, we investigated the interaction of SP and SP fragments with NK1 sites in fresh striatal slices, the same model used in the ...

journal_title：Neuroreport

authors： Michael-Titus AT,Blackburn D,Connolly Y,Priestley JV,Whelpton R

更新日期：1999-07-13 00:00:00

abstract：:In primary cultures from rat cerebral cortex, pituitary adenylate cyclase-activating polypeptide (PACAP-38) exerted a protective effect on cell death induced by the excitotoxin NMDA in neuron-enriched cultures and also on apoptotic cell death induced by serum deprivation in mixed neuronal-glial cultures. The neuroprot...

journal_title：Neuroreport

authors： Frechilla D,García-Osta A,Palacios S,Cenarruzabeitia E,Del Rio J

更新日期：2001-04-17 00:00:00

abstract：:We examined the role of main and external cuneate nuclei neurons in processing sensory information during forelimb passive movement. We recorded activity of neurons using circular and figure-eight trajectories, at different speeds, in anaesthetized rats. A multivariate regression analysis was performed to correlate ne...

journal_title：Neuroreport

authors： Garifoli A,Caserta C,Bosco G,Lombardo SA,Casabona A,Perciavalle V

更新日期：2002-03-04 00:00:00

abstract：:Axonal atrophy may reflect earlier and more reversible events in neurodegeneration and ageing than somatic atrophy. Innervation density by sympathetic fibres from the rat superior cervical ganglion (SCG) to the middle cerebral artery (MCA) decreases dramatically in old age, while that to the iris is largely unchanged....

journal_title：Neuroreport

authors： Kuchel GA,Poon T,Irshad K,Richard C,Julien JP,Cowen T

更新日期：1997-02-10 00:00:00

abstract：:Ascorbate and glutathione (GSH) are the primary water-soluble antioxidants in the CNS. Oxidative stress, sometimes indicated by loss of these antioxidants, has been linked to several clinical and experimental conditions, including cerebral ischemia. These conditions are also gender-linked, with greater incidence or se...

journal_title：Neuroreport

authors： Ferris DC,Kume-Kick J,Russo-Menna I,Rice ME

更新日期：1995-07-31 00:00:00

abstract：:Nerve growth factor (NGF) is trophic to sensory and sympathetic fibres, and ciliary neurotrophic factor (CNTF) to motoneurones, in animal models of peripheral nerve injury: NGF excess produces hyperalgesia. In this first study of injured human nerves and sensory ganglia, we quantified and localized endogenous NGF and ...

journal_title：Neuroreport

authors： Anand P,Terenghi G,Birch R,Wellmer A,Cedarbaum JM,Lindsay RM,Williams-Chestnut RE,Sinicropi DV

更新日期：1997-05-27 00:00:00

abstract：:Beta-N-methylamino-L-alanine (BMAA) is a nonprotein amino acid that may be involved in neurodegenerative diseases. It is produced by a large variety of cyanobacteria and is found at high levels in the brains of Alzheimer's disease and amyotrophic lateral sclerosis patients. Although BMAA is clearly a neurotoxin, previ...

journal_title：Neuroreport

authors： Liu XQ,Rush T,Ciske J,Lobner D

更新日期：2010-01-06 00:00:00

abstract：:This study examined the relationship between social anxiety and the neural processing of threat in faces. Twenty-one adults with different levels of society anxiety were tested for their event-related potential responses to unattended threatening and nonthreatening faces, presented upright and upside-down, at three po...

journal_title：Neuroreport

authors： Sewell C,Palermo R,Atkinson C,McArthur G

更新日期：2008-08-27 00:00:00

abstract：:The serotonin transporter (SERT) terminates serotonergic neurotransmission by rapid reuptake of 5-hydroxytryptamine (5-HT) into the nerve terminal or axonal varicosities. SERT represents the target of various antidepressants which inhibit 5-HT transport and are widely used for the pharmacotherapy of depression. Here, ...

journal_title：Neuroreport

authors： Horschitz S,Hummerich R,Schloss P

更新日期：2001-07-20 00:00:00

abstract：:For the majority of neurones in cat striate cortex, the response to an optimal stimulus presented to one eye is suppressed when a stimulus of substantially different orientation is presented to the other eye. In order to determine the true orientational tuning of the underlying inhibitory interactions in the absence o...

journal_title：Neuroreport

authors： Sengpiel F,Freeman TC,Blakemore C

更新日期：1995-11-13 00:00:00

abstract：:We used fMRI to reveal the visual cortical activations during conventional or electro-acupuncture over four vision-implicated acupoints in 18 healthy volunteers and compared the results with those obtained during direct visual stimulation. Positive activations were seen over the visual cortex during visual stimulation...

journal_title：Neuroreport

authors： Li G,Cheung RT,Ma QY,Yang ES

更新日期：2003-04-15 00:00:00

abstract：:Both extracellular guanosine and adenosine stimulated astrocyte proliferation in vitro and increased intracellular cAMP 6-fold within 2 min. The effects of both guanosine and adenosine on proliferation and cAMP levels were inhibited by antagonists of adenosine A2 receptors but augmented by A1 receptor antagonists. The...

journal_title：Neuroreport

authors： Rathbone MP,Middlemiss PJ,DeLuca B,Jovetich M

更新日期：1991-11-01 00:00:00

abstract：:Cyclin-dependent kinases (CDK) mediate the cell division cycle during G1 phase and CDK inhibitors negatively regulate the cell cycle. We investigated expression of the CDK inhibitor p27Kip1 and the effects of PI-3K/Akt on proliferation of progenitors in the subventricular zone of adult rat. Western blots and immunosta...

journal_title：Neuroreport

authors： Zhang R,Zhang Z,Tsang W,Wang L,Chopp M

更新日期：2004-08-06 00:00:00

abstract：:We report an investigation into the processing of symmetrical lexical stimuli by a patient with moderate visual neglect. This subject's neglect dyslexia was significantly less pronounced when presented with symmetrical lexical stimuli (palindromes) than with matched non-symmetrical words. We discuss the hypothesis tha...

journal_title：Neuroreport

authors： Shillcock RC,Kelly ML,Monaghan P

更新日期：1998-09-14 00:00:00

abstract：:Previous studies have indicated that estrogen protects the brain from ischemic damage and regulates K(ATP) channel activity; the present study was designed to address the involvement of K(ATP) channels in the neuroprotective effects of estrogen in focal cerebral ischemia: in experiment 1, K(ATP) mRNA and protein in th...

journal_title：Neuroreport

authors： Zhang D,Xia H,Xu L,Zhang C,Yao W,Wang Y,Ren J,Wu J,Tian Y,Liu W,Wang X

更新日期：2012-11-14 00:00:00

abstract：:The H-Tx rat is a polygenic inherited model of hydrocephalus. In order to identify disease-specific biomarkers associated with congenital hydrocephalus, comparative proteomic analysis was used to screen cerebellum proteins in H-Tx rats at 1 day after birth. Seven proteins showed significant changes in hydrocephalic H-...

journal_title：Neuroreport

authors： Li X,Miyajima M,Mineki R,Taka H,Murayama K,Arai H

更新日期：2005-04-25 00:00:00

abstract：:The present study examined the neuroprotective effects of choroid plexus isolated from adult rats and encapsulated within alginate microcapsules. In vitro, conditioned media from cultured choroid plexus produced a marked, dose-dependent protection of embryonic cortical neurons against serum deprivation-induced cell de...

journal_title：Neuroreport

authors： Borlongan CV,Skinner SJ,Geaney M,Vasconcellos AV,Elliott RB,Emerich DF

更新日期：2004-07-19 00:00:00

abstract：:Blood oxygen level dependent MRI was used to test whether cocaine-stimulated mesolimbic activity varied with sexual receptivity. Rats were randomly screened for lordotic responses and were then imaged for their responses to centrally administered cocaine. We observed that female rats expressing no lordosis showed a gr...

journal_title：Neuroreport

authors： Febo M,Segarra AC,Stolberg TL,Ferris CF

更新日期：2011-01-05 00:00:00

abstract：OBJECTIVE:Cervical spondylotic myelopathy is regarded as a chronic, special incomplete spinal cord injury, so the sensory components transmitted to thalamus decreased after distal spinal cord injury, which lead the disturbance of thalamus-cortex circuits, which might explain the alterations of clinical function of cerv...

journal_title：Neuroreport

authors： Peng X,Tan Y,He L,Ou Y

更新日期：2020-03-25 00:00:00

abstract：:Neurotrophins are promising candidates to slow the progression of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease in which spinal and cortical motoneurons selectively degenerate. In a long-term in vitro model, malonate-induced toxicity and cell death of motoneurons have been demonstrated. Here we stud...

journal_title：Neuroreport

authors： Van Westerlaak MG,Bär PR,Cools AR,Joosten EA

更新日期：2001-05-25 00:00:00

abstract：:As the most numerous cell type in the brain, astrocytes are coupled via gap junction channels. It is believed that communication among astrocytes is normally regulated by extracellular ions, neurotransmitters and neuromodulators. However, the level of astrocytic coupling is altered in abnormal conditions such as strok...

journal_title：Neuroreport

authors： Bani-Yaghoub M,Felker JM,Naus CC

更新日期：1999-12-16 00:00:00

abstract：:The octave illusion is experienced when two simultaneous tones, separated by one octave and presented to the opposite ears, are continuously reversed between the two ears. Subjects consistently report a sequence of alternating single tones: the high tone in the right ear and the low in the left. We wished to determine...

journal_title：Neuroreport

authors： Ross J,Tervaniemi M,Näätänen R

更新日期：1996-12-20 00:00:00

abstract：:Several neurophysiological studies have highlighted the role of the midbrain periaqueductal gray matter (PAG) in the initiation of vocalization in various animal species, from frogs to primates. With regard to humans, only two cases of complete mutism following a lesion to the PAG have been reported so far. This artic...

journal_title：Neuroreport

authors： Esposito A,Demeurisse G,Alberti B,Fabbro F

更新日期：1999-03-17 00:00:00

abstract：:Skin sensory nerve nocifensor functions were investigated non-invasively in rats by measuring neurogenic inflammation and blister healing-rate after unilateral hindlimb denervation. Axon reflexes were evoked by transdermal iontophoresis of acetylcholine (ACh) or noxious electrical stimulation (TNS). Sodium nitroprussi...

journal_title：Neuroreport

authors： Carr RW,Delaney CA,Westerman RA,Roberts RG

更新日期：1993-05-01 00:00:00

abstract：:We investigated the effect of the muscarinic acetylcholine receptor (mAChR) antagonist scopolamine on eyeblink conditioning in glutamate receptor subunit 62 null mice, which have severe impairments in cerebellar long-term depression (LTD). Mice were injected intraperitoneally with scopolamine (0.5 mg/kg) or saline, an...

journal_title：Neuroreport

authors： Takatsuki K,Kawahara S,Mori H,Mishina M,Kirino Y

更新日期：2002-01-21 00:00:00

abstract：:The NMDA receptor is one of the ionotropic glutamate receptors essential for excitatory neurotransmission. The NMDAR1 subunit is inactivated by direct interaction with calmodulin. The protein levels of calmodulin, NMDAR1 and their complex were quantified in tissue resected from epileptogenic and non-epileptogenic cort...

journal_title：Neuroreport

authors： Mikuni N,Nishiyama K,Babb TL,Ying Z,Najm I,Okamoto T,Lüders HO,Wylie C

更新日期：1999-05-14 00:00:00

abstract：:Delayed neuronal death induced by transient forebrain ischemia in the rat hippocampus is preceded by a prominent microglial reaction which begins within minutes after the ischemic injury. In the present study we have examined the effect of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 on m...

journal_title：Neuroreport

authors： Streit WJ,Morioka T,Kalehua AN

更新日期：1992-02-01 00:00:00

abstract：:Fourteen healthy right-handed subjects were scanned using PET with a [15O]water tracer during exposure to electromagnetic field (EMF) emitted by a mobile phone and a sham-exposure under double-blind conditions. During scanning, the subjects performed a visual working memory task. Exposure to an active mobile phone pro...

journal_title：Neuroreport

authors： Haarala C,Aalto S,Hautzel H,Julkunen L,Rinne JO,Laine M,Krause B,Hämäläinen H

更新日期：2003-11-14 00:00:00