Abstract:
:We investigated whether in vivo excitotoxicity was mediated by a mechanism of programmed cell death called apoptosis. Neurotoxic doses of kainic acid (1.2 nmol) and quinolinic acid (120 nmol) were unilaterally injected in the dorsal hippocampus of anesthetized rats. Eight or 16 h later the animals were killed and DNA was extracted from the injected hippocampi. DNA from mouse thymocytes exposed to methylprednisolone (10(-5) M for 6 h at 37 degrees C) was used as a positive control of apoptotic cells. No typical 'ladder' of DNA fragments (multimers of approximately 200 Kb) which characterizes apoptosis was seen in hippocampal cells after toxic doses of kainic or quinolinic acid, as assessed by agarose gel electrophoresis. This suggests that hippocampal nerve cell death induced in vivo by the excitotoxins is not mediated by apoptosis.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Ignatowicz E,Vezzani AM,Rizzi M,D'Incalci Mdoi
10.1097/00001756-199111000-00004subject
Has Abstractpub_date
1991-11-01 00:00:00pages
651-4issue
11eissn
0959-4965issn
1473-558Xjournal_volume
2pub_type
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