Abstract:
:Hydrogen peroxide (H₂O₂) is a ubiquitous reactive oxygen species that can induce several inner ear disorders. In this study, we recorded the potassium (K) currents in acutely isolated inner hair cells of guinea pig cochlea, and investigated the effects of H₂O₂. We also observed the morphological changes in inner hair cells induced by H₂O₂. In the H₂O₂ solutions, the amplitude of outward K currents (I(K,f) and I(K,s)) clearly decreased after perfusion for approximately 15 min. Despite the decrease in outward currents, small inward currents (I(K,n)) did not show any reduction. H₂O₂ induced morphological changes in the inner hair cells. All the inner hair cells in the H₂O₂ solutions showed shrinkage and granularity of the cell body and led to loss of viability. These results showed the vulnerability of inner hair cells to reactive oxygen species-induced inner ear disorders.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Kimitsuki T,Komune N,Noda T,Takaiwa K,Ohashi M,Komune Sdoi
10.1097/WNR.0b013e32833fcb56subject
Has Abstractpub_date
2010-11-17 00:00:00pages
1045-9issue
16eissn
0959-4965issn
1473-558Xjournal_volume
21pub_type
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