Abstract:
:Exposure of primary murine cortical neuron cultures to N-methyl-D-aspartate (NMDA) resulted in neuronal death as evidenced by release of lactate dehydrogenase (LDH) into the media. The addition of N-nitro-L-arginine (N-Arg) protected the neurons from death in a concentration-dependent manner when added after the NMDA, but not when the N-Arg was present with the NMDA. Protection by N-Arg was lost if L-arginine containing media was added to the cultures prior to the addition of the N-Arg. Treatment of the neurons with kainate prior to NMDA reduced subsequent NMDA-induced damage which was not prevented with N-Arg. These results suggest that delayed production of nitric oxide (NO) contributes to NMDA-induced neuronal damage in culture.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Reif DWdoi
10.1097/00001756-199305000-00026subject
Has Abstractpub_date
1993-05-01 00:00:00pages
566-8issue
5eissn
0959-4965issn
1473-558Xjournal_volume
4pub_type
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