Adult interleukin-6 knockout mice show compromised neurogenesis.

abstract：:The ability to attribute mental states to others ('theory of mind') pervades normal social interaction and is impaired in autistic individuals. In a previous positron emission tomography scan study of normal volunteers, performing a 'theory of mind' task was associated with activity in left medial prefrontal cortex. W...

journal_title：Neuroreport

authors： Happé F,Ehlers S,Fletcher P,Frith U,Johansson M,Gillberg C,Dolan R,Frackowiak R,Frith C

更新日期：1996-12-20 00:00:00

abstract：:Amyloid beta-peptide (Abeta) accumulation in aged Sprague-Dawley rats (12 months) with kaolin-induced hydrocephalus was investigated by Abeta(1-40) and Abeta(1-42) immunohistochemistry at 2, 6 and 10 weeks after induction. The low-density lipoprotein receptor-related protein-1 transporting Abeta across the blood-brain...

journal_title：Neuroreport

authors： Klinge PM,Samii A,Niescken S,Brinker T,Silverberg GD

更新日期：2006-04-24 00:00:00

abstract：:The temporal lobe regions involved in memory retrieval were examined using fMRI. During an associative recognition test, participants made memory judgments about the study color of previously presented drawings of objects, and during item recognition tests they made old/new judgments about previously studied objects o...

journal_title：Neuroreport

authors： Yonelinas AP,Hopfinger JB,Buonocore MH,Kroll NE,Baynes K

更新日期：2001-02-12 00:00:00

abstract：:Brain slice preparations obtained from the rat were used to study cholinergic GABAergic interaction in mechanisms responsible for production of theta-like activity in hippocampal slices maintained in vitro. Bicuculline, a GABA-A antagonist, applied at 25 microM facilitated the effect of low concentration carbachol (25...

journal_title：Neuroreport

authors： Konopacki J,Gołebiewski H

更新日期：1993-07-01 00:00:00

abstract：:PEC-60, a 60-residue intestinal peptide structurally related to the pancreatic secretory type of trypsin inhibitor, has been isolated, characterized and molecularly cloned. It shows biological activity as a hormone in both the gastrointestinal tract and in the immune system. We now report immunohistochemical evidence ...

journal_title：Neuroreport

authors： Fuxe K,Tinner B,Metsis M,Staines W,Morassutti D,Agnati LF,Ostensson CG,Efendic S,Agerberth B,Goldstein M

更新日期：1994-09-08 00:00:00

abstract：:Previously we found that musicians have significantly larger anterior corpus callosum (CC). In the current study, we intended to replicate and extend our previous results using a new and larger sample of gender-matched subjects (56 right-handed professional musicians and 56 age- and handedness-matched controls). We fo...

journal_title：Neuroreport

authors： Lee DJ,Chen Y,Schlaug G

更新日期：2003-02-10 00:00:00

abstract：:It has been widely shown that recognition memory includes two distinct retrieval processes: familiarity and recollection. Many studies have shown that recognition memory can be facilitated when there is a perceptual match between the studied and the tested items. Most event-related potential studies have explored the ...

journal_title：Neuroreport

authors： Cui X,Gao C,Zhou J,Guo C

更新日期：2016-09-28 00:00:00

abstract：:While effects of attention on late and middle latency components of the evoked potential have been demonstrated, similar effects on brain stem evoked potentials--in particular on the human frequency-following potential (FFP)--are controversial. The FFP is a response to tone bursts in the frequency range of human langu...

journal_title：Neuroreport

authors： Hoormann J,Falkenstein M,Hohnsbein J

更新日期：1994-08-15 00:00:00

abstract：:We investigated the effect of the muscarinic acetylcholine receptor (mAChR) antagonist scopolamine on eyeblink conditioning in glutamate receptor subunit 62 null mice, which have severe impairments in cerebellar long-term depression (LTD). Mice were injected intraperitoneally with scopolamine (0.5 mg/kg) or saline, an...

journal_title：Neuroreport

authors： Takatsuki K,Kawahara S,Mori H,Mishina M,Kirino Y

更新日期：2002-01-21 00:00:00

abstract：:Dichotic pitches and mistuned harmonics can each lead to the perception of one or two auditory objects. Comparison of event-related potentials for the perception of one versus two objects reveals an early negative and a late positive component. The relationship of these components with auditory segregation was further...

journal_title：Neuroreport

authors： Hautus MJ,Johnson BW,Colling LJ

更新日期：2009-07-01 00:00:00

abstract：:Multiple sclerosis is associated with reduced white matter integrity and deficits in key cognitive processes important for arithmetic. This study examined the relationship between white matter microstructure and academic ability in 31 youths with multiple sclerosis (aged 11-19 years) and 34 demographically matched con...

journal_title：Neuroreport

authors： Till C,Deotto A,Tipu V,Sled JG,Bethune A,Narayanan S,Arnold DL,Banwell BL

更新日期：2011-12-21 00:00:00

abstract：:Substantial evidence suggests a negative association between cigarette smoking and the incidence and severity of ulcerative colitis, a common human inflammatory bowel disease. Nicotine has been implicated in this association. The detection of nicotinic acetylcholine receptors in colonic epithelium, the primary tissue ...

journal_title：Neuroreport

authors： Orr-Urtreger A,Kedmi M,Rosner S,Karmeli F,Rachmilewitz D

更新日期：2005-07-13 00:00:00

abstract：:The cellular distribution of the type VI human voltage-gated sodium channel (Type VI) was examined in selected human brain regions. Antibodies designed to be specific to rat and human Type VI were raised against a synthetic peptide from the predicted NH2-terminal of the protein, and used for an immunohistochemical inv...

journal_title：Neuroreport

authors： Whitaker W,Faull R,Waldvogel H,Plumpton C,Burbidge S,Emson P,Clare J

更新日期：1999-11-26 00:00:00

abstract：:Surface texture can be perceived not only from tactile, but also from auditory and visual sensory cues. In our previous psychophysical study, we demonstrated that humans can recognize surface stickiness using only one kind of sensory modality without any difficulty. However, the brain regions that would be activated b...

journal_title：Neuroreport

authors： So Y,Kim SP,Kim J

更新日期：2020-03-25 00:00:00

abstract：:We have investigated the hypothesis that the acute ischemic swelling of the radial dendrites connected to the inner hair cells (IHCs) is mediated by glutamatergic receptors. In control cochleas, after 20 min ischemia all the dendrites were dramatically swollen. Conversely, after a perfusion of 50 microM 6-7-dinitroqui...

journal_title：Neuroreport

authors： Pujol R,Puel JL,Eybalin M

更新日期：1992-04-01 00:00:00

abstract：:The amount of backward walking induced in mice by co-administration of clenbuterol, a beta-adrenoceptor agonist and putative antidepressant, and the benzodiazepine chlordiazepoxide was plotted as a three-dimensional surface, using modified Uniras software. The surface was compared with the theoretical surface to be ex...

journal_title：Neuroreport

authors： Hughes MJ,Sykes EA,Steinberg H

更新日期：1992-07-01 00:00:00

abstract：:AMPA-preferring glutamate receptor genes gluR1-4 undergo alternative splicing into flip and flop mRNA isoforms. In the rodent hippocampus, gluR1 and gluR2 isoforms are differentially expressed. We have studied their distribution in human hippocampus. As in the rat, flop isoforms predominate over flip in dentate gyrus,...

journal_title：Neuroreport

authors： Eastwood SL,Burnet PW,Beckwith J,Kerwin RW,Harrison PJ

更新日期：1994-06-27 00:00:00

abstract：:The functional organization of intrinsic connections in the cat motor cortex was examined by combining intracortical microstimulation with neuroanatomical tracers. After single injections of a dye into a cortical site from which wrist flexion was evoked, clusters of retrogradely labeled somata and of anterogradely lab...

journal_title：Neuroreport

authors： Keller A

更新日期：1993-05-01 00:00:00

abstract：:Acid-sensing ion channels (ASICs) constitute a branch of the super-gene family of amiloride-sensitive sodium channels. So far five different ASICs have been cloned from mammalian tissues. They are activated by a drop of extracellular pH but differ with respect to effective agonist concentration, desensitization and mR...

journal_title：Neuroreport

authors： Gründer S,Geissler HS,Bässler EL,Ruppersberg JP

更新日期：2000-06-05 00:00:00

abstract：:Optic nerves of adult rats were crushed 2 mm behind the eye to examine the ability of retinal ganglion cells (RGCs) to regenerate their axons. Some animals were treated with the immunophilin ligands FK 506 or GPI 1046 for up to 4 weeks. After 10 days to 16 months, regenerating RGC axons were visualized using anterogra...

journal_title：Neuroreport

authors： Campbell G,Holt JK,Shotton HR,Anderson PN,Bavetta S,Lieberman AR

更新日期：1999-12-16 00:00:00

abstract：:The perifornical-lateral hypothalamic area is implicated in regulating waking and paradoxical sleep. The blockade of GABAA receptors by iontophoretic applications of bicuculline (or gabazine) into the perifornical-lateral hypothalamic area induced a continuous quiet waking state associated to a robust muscle tone in h...

journal_title：Neuroreport

authors： Goutagny R,Luppi PH,Salvert D,Gervasoni D,Fort P

更新日期：2005-07-13 00:00:00

abstract：:Although a large amount of studies have manifested resting state electroencephalogram oscillatory abnormalities in schizophrenia and their first-degree relatives and in schizotype, the results are far from consistent and no research found any relationship between electroencephalograph (EEG) abnormalities and schizotyp...

journal_title：Neuroreport

authors： Chen C,Huang W,Chen X,Shi X,Zhu X,Ma W,Wang Y,Kang Q,Wang X,Guan M,Huang H,Wu S,Liu X

更新日期：2019-12-10 00:00:00

abstract：:Semi-quantitative single cell RT-PCR techniques were used to determine the expression of mRNAs related to GABAergic and cholinergic neurotransmission in neurons of the rat globus pallidus and adjacent basal forebrain region. Neurons of the globus pallidus expressed relatively high levels of GAD67 and GABA vesicular tr...

journal_title：Neuroreport

authors： Tkatch T,Baranauskas G,Surmeier DJ

更新日期：1998-06-22 00:00:00

abstract：:The neurotransmitter acetylcholine is synthesized by choline acetyltransferase (ChAT) and transported into synaptic vesicles by the vesicular acetylcholine transporter (VAChT). Recently it has been reported that the entire coding region of VAChT mRNA is located in the first intron of the ChAT gene. In this study, ChAT...

journal_title：Neuroreport

authors： Misawa H,Takahashi R,Deguchi T

更新日期：1995-05-09 00:00:00

abstract：:Ca2+/calmodulin-dependent protein kinase II (CaMKII) plays critical roles in neurotransmission, synaptic plasticity, learning and memory. The aim of this study was to examine, by in situ hybridization, prefrontal cortical expression of CaMKII alpha mRNA in postmortem brains of unipolar, bipolar, schizophrenic, and con...

journal_title：Neuroreport

authors： Xing G,Russell S,Hough C,O'Grady J,Zhang L,Yang S,Zhang LX,Post R

更新日期：2002-03-25 00:00:00

abstract：:The functional integrity of the 'on' and 'off' neurovisual pathways has been examined in the central visual fields of normal (n = 13), glaucomatous (n = 21) and ocular hypertensive (n = 21) individuals. The detection thresholds to light increments (onsets = bright spots) and light decrements (offsets = dark spots) on ...

journal_title：Neuroreport

authors： Mutlukan E

更新日期：1993-09-03 00:00:00

abstract：:To test the hypothesis that the pedunclopontine tegmental nucleus (PPTg) plays a role in anxiety, rats with electrolytic lesions of the PPTg were tested in two animal models of anxiety, the elevated plus maze and the social interaction tests. Histological analysis showed that lesions were concentrated on the caudal ha...

journal_title：Neuroreport

authors： Podhorna J,Franklin KB

更新日期：1998-06-01 00:00:00

abstract：:The hypothesis that sleep participates in the consolidation of recent memory traces has been investigated using four main paradigms: (1) effects of post-training sleep deprivation on memory consolidation, (2) effects of learning on post-training sleep, (3) effects of within sleep stimulation on the sleep pattern and o...

journal_title：Neuroreport

authors： Peigneux P,Laureys S,Delbeuck X,Maquet P

更新日期：2001-12-21 00:00:00

abstract：:Deficits in processing of auditory stimuli are known to play an important role in the aetiology of dyslexia. To specify the auditory deficit in children at risk for dyslexia, 19 children with a phonological deficit and 15 controls were tested using the mismatch negativity event-related potential, which reflects preatt...

journal_title：Neuroreport

authors： Bitz U,Gust K,Spitzer M,Kiefer M

更新日期：2007-06-11 00:00:00

abstract：:Our aim was to visualize the dynamic features of Ca2+/calmodulin-dependent protein kinase II (CaMKII) activity. In order to do so, we synthesized a new reagent by conjugating a fluoroprobe, 6-acryloyl-2-dimethylaminonaphthalene (acrylodan), to syntide 2, a specific peptide substrate for CaMKII. In cell-free conditions...

journal_title：Neuroreport

authors： Higashi H,Sato K,Omori A,Sekiguchi M,Ohtake A,Kudo Y

更新日期：1996-11-04 00:00:00