Abstract:
:The ability to attribute mental states to others ('theory of mind') pervades normal social interaction and is impaired in autistic individuals. In a previous positron emission tomography scan study of normal volunteers, performing a 'theory of mind' task was associated with activity in left medial prefrontal cortex. We used the same paradigm in five patients with Asperger syndrome, a mild variant of autism with normal intellectual functioning. No task-related activity was found in this region, but normal activity was observed in immediately adjacent areas. This result suggests that a highly circumscribed region of left medial prefrontal cortex is a crucial component of the brain system that underlies the normal understanding of other minds.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Happé F,Ehlers S,Fletcher P,Frith U,Johansson M,Gillberg C,Dolan R,Frackowiak R,Frith Cdoi
10.1097/00001756-199612200-00040subject
Has Abstractpub_date
1996-12-20 00:00:00pages
197-201issue
1eissn
0959-4965issn
1473-558Xjournal_volume
8pub_type
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