Abstract:
:The Flinders sensitive line of rats is a widely accepted and validated model of depression. These rats demonstrate abnormalities in limbic dopamine neurotransmission, suggesting disturbed neuronal activity in the ventral tegmental area. Interspike interval time-series were recorded from the ventral tegmental area of control Sprague-Dawley and Flinder sensitive line rats. These data were analyzed using standard measures (mean firing rate, bursting activity and spectral analysis) as well as the pointwise correlation dimension, a nonlinear measurement characterizing the complexity degree of dynamic systems. Pointwise correlation dimension, but not standard analysis revealed a significant difference between the animal lines. Our results suggest that nonlinear analyses can detect dysregulation of the mesolimbic dopaminergic system and shed light on the pathophysiology of depression.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Dremencov E,Nahshoni E,Levy D,Mintz M,Overstreet DH,Weizman A,Yadid Gdoi
10.1097/00001756-200408260-00030subject
Has Abstractpub_date
2004-08-26 00:00:00pages
1983-6issue
12eissn
0959-4965issn
1473-558Xpii
00001756-200408260-00030journal_volume
15pub_type
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