Abstract:
:The present study used c-Fos expression to examine cellular activity in cholinergic regions in the basal forebrain (BF) following enforced waking and recovery sleep. Cholinergic cells within the vertical and horizontal limbs of the diagonal band of Broca (VDB and HDB, respectively) showed significantly higher c-Fos immunoreactivity after prolonged waking than after recovery sleep. Cholinergic cells within the medial septal nucleus (MS), however, showed no change in c-Fos expression under these conditions. Consistent with our previous findings, c-Fos immunoreactivity in the ventral lateral preoptic area (VLPO) was increased after 1-2h of recovery sleep compared with enforced waking. These results indicate state-specific effects on transcription and subsequent protein expression in cell populations associated with behavioral state and further show that the HDB, VDB and VLPO are good candidates for the further study of intracellular events associated with sleep and wakefulness.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Greco MA,Lu J,Wagner D,Shiromani PJdoi
10.1097/00001756-200002280-00002subject
Has Abstractpub_date
2000-02-28 00:00:00pages
437-40issue
3eissn
0959-4965issn
1473-558Xjournal_volume
11pub_type
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