Abstract:
:Cerebral blood flow (CBF) was measured at varying haematocrit values in 8 streptozotocin-diabetic and in 7 control rats using the intracarotid 133Xe technique. A hyperbolic relationship between CBF and haematocrit was established for the individual rats in both groups. Diabetic animals showed a preserved CBF response to changes to haematocrit. In 10 normal rats, CBF was measured during acute hyperglycaemia induced by intraperitoneal glucose injection. A significant, inverse correlation was found between CBF and blood glucose. We conclude that the CBF response to changes in haematocrit and thereby in pO2 is preserved in experimental diabetes. Secondly, in acute hyperglycaemia CBF varies inversely with blood glucose, by mechanisms not fully understood.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Knudsen GM,Tedeschi E,Jakobsen Jdoi
10.1097/00001756-199211000-00010subject
Has Abstractpub_date
1992-11-01 00:00:00pages
987-9issue
11eissn
0959-4965issn
1473-558Xjournal_volume
3pub_type
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