Abstract:
:In this study, the brainstem-spinal cord preparation isolated from newborn rats, an established model for the study of the hypoxic respiratory depression (HRD), has been used. The comparison of Fos expression in ponto-medullary areas in these preparations placed either in normoxic or hypoxic conditions suggests that only the retrotrapezoid nucleus (RTN) and the ventrolateral medulla (VLM) are involved in the in vitro HRD. Hypoxic preparations exhibit a Fos expression enhanced in the RTN, suggesting that the RTN might play a crucial role in the HRD. As well as this, VLM neurons presented a decrease in Fos expression that could be related to the decline of the respiratory output induced by hypoxia.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Bodineau L,Cayetanot F,Frugière Adoi
10.1097/00001756-200112210-00012subject
Has Abstractpub_date
2001-12-21 00:00:00pages
3913-6issue
18eissn
0959-4965issn
1473-558Xjournal_volume
12pub_type
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