Abstract:
:Amygdala and insula hyper-reactivity to threat is implicated in social anxiety disorder (SAD) yet inconsistencies in activation have been reported. One source of variance are individual differences in 5-HTTLPR genotype where the short (S), relative to long (L) allele, corresponds with greater amygdala activation. However, the impact of genotype on insula to threat in SAD is not known. During functional MRI, 34 SAD patients and 28 healthy controls completed a perceptual assessment task comprising angry, fear, and happy faces. Results showed no diagnostic group differences in limbic/paralimbic regions but within SAD, greater insula, but not amygdala, activation to fearful faces was observed in patients with SS genotype compared with LaLa genotype. Findings indicate genotype influenced insula activation to threat in SAD.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Klumpp H,Fitzgerald DA,Cook E,Shankman SA,Angstadt M,Phan KLdoi
10.1097/WNR.0000000000000210subject
Has Abstractpub_date
2014-08-20 00:00:00pages
926-31issue
12eissn
0959-4965issn
1473-558Xpii
00001756-201408200-00008journal_volume
25pub_type
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