Nitric oxide synthase inhibition decreases pontine acetylcholine release.

Abstract:

:This study tested the hypothesis that inhibition of nitric oxide synthase (NOS) in the medial pontine reticular formation (mPRF) would cause decreased acetylcholine (ACh) release. Microdialysis of cat mPRF permitted measurement of ACh during states of wakefulness, non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep. ACh release during microdialysis with Ringers (control) was compared to ACh release during microdialysis with 10 mM NG-nitro-L-arginine (NLA). The NOS inhibitor NLA caused a significant reduction in ACh released from the mPRF during wakefulness, NREM sleep, and REM sleep. This reduction in mPRF ACh release elicited by NLA suggests that nitric oxide (NO) contributes to cholinergic neurotransmission in the pontine reticular formation.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Leonard TO,Lydic R

doi

10.1097/00001756-199507310-00015

subject

Has Abstract

pub_date

1995-07-31 00:00:00

pages

1525-9

issue

11

eissn

0959-4965

issn

1473-558X

journal_volume

6

pub_type

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