Abstract:
:This study tested the hypothesis that inhibition of nitric oxide synthase (NOS) in the medial pontine reticular formation (mPRF) would cause decreased acetylcholine (ACh) release. Microdialysis of cat mPRF permitted measurement of ACh during states of wakefulness, non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep. ACh release during microdialysis with Ringers (control) was compared to ACh release during microdialysis with 10 mM NG-nitro-L-arginine (NLA). The NOS inhibitor NLA caused a significant reduction in ACh released from the mPRF during wakefulness, NREM sleep, and REM sleep. This reduction in mPRF ACh release elicited by NLA suggests that nitric oxide (NO) contributes to cholinergic neurotransmission in the pontine reticular formation.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Leonard TO,Lydic Rdoi
10.1097/00001756-199507310-00015subject
Has Abstractpub_date
1995-07-31 00:00:00pages
1525-9issue
11eissn
0959-4965issn
1473-558Xjournal_volume
6pub_type
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