Abstract:
:Deficits of working memory (WM) are recognized as an important pathological feature in schizophrenia. Since the P600 component of event related potentials has been hypothesized that represents aspects of second-pass parsing processes of information processing, and is related to WM, the present study focuses on P600 elicited during a WM test in drug-naive first-episode schizophrenics (FES) compared to healthy controls. We examined 16 drug-naive first-episode schizophrenic patients and 23 healthy controls matched for age and sex. Compared with controls schizophrenic patients showed reduced P600 amplitude on left temporoparietal region and increased P600 amplitude on left occipital region. With regard to the latency, the patients exhibited significantly prolongation on right temporoparietal region. The obtained pattern of differences classified correctly 89.20% of patients. Memory performance of patients was also significantly impaired relative to controls. Our results suggest that second-pass parsing process of information processing, as indexed by P600, elicited during a WM test, is impaired in FES. Moreover, these findings lend support to the view that the auditory WM in schizophrenia involves or affects a circuitry including temporoparietal and occipital brain areas.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Papageorgiou C,Kontaxakis VP,Havaki-Kontaxaki BJ,Stamouli S,Vasios C,Asvestas P,Matsopoulos GK,Kontopantelis E,Rabavilas A,Uzunoglu N,Christodoulou GNdoi
10.1097/00001756-200109170-00010subject
Has Abstractpub_date
2001-09-17 00:00:00pages
2801-6issue
13eissn
0959-4965issn
1473-558Xjournal_volume
12pub_type
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