Abstract:
:The time course of responses to repeated presentations of affective stimuli is well characterized in healthy individuals but remains to be characterized in patients with bipolar disorder. Using functional magnetic resonance imaging, we compared early-stage and late-stage brain activation during a two-block fearful face perception task in 14 adult bipolar patients to that of 13 healthy controls. Whereas control participants showed increased orbitofrontal, anterior cingulate, and striatum activity during the late (vs. early) stage of the task, bipolar patients failed to show normal task-related activity in these regions. Results suggest that bipolar disorder may involve corticostriatal dysfunction.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Killgore WD,Gruber SA,Yurgelun-Todd DAdoi
10.1097/WNR.0b013e328310af58subject
Has Abstractpub_date
2008-10-08 00:00:00pages
1523-7issue
15eissn
0959-4965issn
1473-558Xpii
00001756-200810080-00016journal_volume
19pub_type
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