Numerical distance effect in the N240 component in a number-matching task.


:The event-related potential technique was used to investigate the time course and scalp-potential topography for the numerical distance effect in a number-matching task. Twenty undergraduates judged whether a number matched or did not match another number presented 1.5 s earlier. Compared with number pairs with a 'small' numerical distance (distance=1), number pairs with a 'large' numerical distance (greater than 2) showed a longer latency and a greater positive amplitude in the N240 component. This numerical distance effect was limited to fronto-central electrodes. These results were discussed in terms of the neural bases of the numerical distance effect during the automatic processing of numbers.






Zhou X,Chen C,Dong Q,Zhang H,Chen C,Qiao S,Zhao H,Jiang T,Guo Y




Has Abstract


2006-07-17 00:00:00














  • Motor imagery in normal subjects and Parkinson's disease patients: an H215O PET study.

    abstract::Motor imagery paradigms can be used to investigate motor preparation. We used positron emission tomography to compare regional cerebral blood flow (rCBF) in patients with Parkinson's disease and normal controls under three conditions: rest, motor imagery and motor execution. In controls, imagery activated bilateral do...


    pub_type: 杂志文章


    authors: Samuel M,Ceballos-Baumann AO,Boecker H,Brooks DJ

    更新日期:2001-03-26 00:00:00

  • 'Theory of mind' in the brain. Evidence from a PET scan study of Asperger syndrome.

    abstract::The ability to attribute mental states to others ('theory of mind') pervades normal social interaction and is impaired in autistic individuals. In a previous positron emission tomography scan study of normal volunteers, performing a 'theory of mind' task was associated with activity in left medial prefrontal cortex. W...


    pub_type: 临床试验,杂志文章


    authors: Happé F,Ehlers S,Fletcher P,Frith U,Johansson M,Gillberg C,Dolan R,Frackowiak R,Frith C

    更新日期:1996-12-20 00:00:00

  • Sulcogyral variation in NMDA receptor 2A/B subunit immunoreactivity in human brain.

    abstract::NMDA receptors (NR) are important in many neurological processes. Using a large series of human brain tissue, we show that the distribution of NR2A/B immunoreactivity varies according to position along a gyrus. For pyramidal neurons in laminae II and III, immunoreactivity is most marked at gyral crown and gyral lips, ...


    pub_type: 杂志文章


    authors: Sisodiya SM,Heffernan J,Harrison PJ,Squier MV,Thom M

    更新日期:2000-08-03 00:00:00

  • The effects of single-trial averaging upon the spatial extent of fMRI activation.

    abstract::We examined effects of trial averaging upon spatial extent, spatial topography, and temporal properties of fMRI activation. Two subjects participated in an event-related visual stimulation design. There was an exponential relation between number of trials and spatial extent, such that additional trials identified, on ...


    pub_type: 杂志文章


    authors: Huettel SA,McCarthy G

    更新日期:2001-08-08 00:00:00

  • GABA inhibition of somatostatin gene expression in cultured hypothalamic neurones.

    abstract::GABAA receptors mediate the inhibition of somatostatin release in hypothalamic neurones. To study the possible effect of GABA on somatostatin biosynthesis, somatostatin and preprosomatostatin mRNA levels were evaluated after exposure of hypothalamic neurones to muscimol or bicuculline. Muscimol (50 microM) decreased p...


    pub_type: 杂志文章


    authors: Rage F,Jalaguier S,Rougeot C,Tapia-Arancibia L

    更新日期:1993-03-01 00:00:00

  • The Xenopus noggin promoter drives roof-plate specific transcription.

    abstract::During vertebrate neural development, inductive signals derived from the roof plate specify dorsal neural cell types of spinal cord as well as adjacent dermomytotome. Noggin has been demonstrated to play a pivotal role in this signaling network but how its expression is regulated remains unclear. To investigate this i...


    pub_type: 杂志文章


    authors: Geng X,Xiao L,Tao Q,Hu R,Rupp RA,Ding X

    更新日期:2003-12-02 00:00:00

  • Quantification of TECTA and DFNA5 expression in the developing mouse cochlea.

    abstract::TECTA and DFNA5 are the mouse orthologues of the human deafness-associated genes TECTA and DFNA5. To determine how expression of these genes is regulated during development, relative mRNA abundance was examined in mice by non-radioactive RT-PCR. TECTA mRNA was detected on embryonic day 15 (E15), increased to its highe...


    pub_type: 杂志文章


    authors: Maeda Y,Fukushima K,Kasai N,Maeta M,Nishizaki K

    更新日期:2001-10-29 00:00:00

  • CD133+ cells from human peripheral blood promote corticospinal axon regeneration.

    abstract::To assess the effect of endothelial progenitor cells on the axon growth of cortex neurons, we transplanted CD133 cells derived from human peripheral blood to an organotypic coculture system consisting of spinal cord and cortex from neonatal rats. The axon growth from cortex to spinal cord was significantly promoted in...


    pub_type: 杂志文章


    authors: Yamamoto R,Ishikawa M,Tanaka N,Kamei N,Nakanishi K,Sasaki H,Nakamae T,Mochizuki Y,Asahara T,Ochi M

    更新日期:2008-05-28 00:00:00

  • Up-regulated CNTF plays a protective role for retrograde degeneration in the axotomized rat retina.

    abstract::Using reverse transcription-polymerase chain reaction and in situ hybridization, we investigated the expression and cellular localization of ciliary neurotrophic factor receptor alpha (CNTFRalpha) in the rat retina following optic nerve transection (ONT). Following ONT, a signal for CNTFRalpha mRNA appeared in a layer...


    pub_type: 杂志文章


    authors: Ju WK,Kim KY,Lee MY,Hofmann HD,Kirsch M,Cha JH,Oh SJ,Chun MH

    更新日期:2000-11-27 00:00:00

  • Long-term potentiation in the perirhinal-hippocampal pathway is NMDA dependent.

    abstract::The putative memory mechanism known as long-term potentiation (LTP) has been described in both NMDA-dependent and non-NMDA-dependent forms. The aim of the present study was to determine which of these forms described the LTP generated between perirhinal cortex (PRC) and hippocampus, two structures which have previousl...


    pub_type: 杂志文章


    authors: Liu P,Bilkey DK

    更新日期:1996-05-17 00:00:00

  • Reduced immunoreactivity of adenylyl cyclase in dementia of the Alzheimer type.

    abstract::The amounts of three adenylyl cyclase (AC) subtypes in membranes from brain obtained post-mortem from patients with dementia of Alzheimer type (DAT) and controls were studied by Western blotting using polyclonal antibodies. AC subtypes were characterized by preabsorption by complementary peptides, species difference, ...


    pub_type: 杂志文章


    authors: Yamamoto M,Ozawa H,Saito T,Frölich L,Riederer P,Takahata N

    更新日期:1996-11-25 00:00:00

  • Chronic paroxetine increases [3H]nociceptin binding in rat dorsal raphe nucleus.

    abstract::Opioid-receptor-like I (ORLI) receptors, ORLI mRNA and nociceptin are particularly abundant in the limbic system and in central monoaminergic areas, brain regions involved in mood regulation and response to antidepressants. To analyse whether ORLI receptors adaptations occur during the first 3 weeks of an antidepressa...


    pub_type: 杂志文章


    authors: Vilpoux C,Naudon L,Costentin J,Leroux-Nicollet I

    更新日期:2002-01-21 00:00:00

  • Superinduction of leptin mRNA in mouse hypothalamic neurons.

    abstract::In marked contrast to several other species, including rats and humans, leptin gene expression is undetectable in mouse brain. This unexpected finding may reflect unique energy regulation pathways in the mouse. We investigated possible mechanisms by which leptin (ob) gene expression is suppressed in mouse brain: (a) t...


    pub_type: 杂志文章


    authors: Brown RE,Wilkinson DA,Wilkinson PM,Imran SA,Wilkinson M

    更新日期:2012-10-24 00:00:00

  • Immunohistochemical localization of the carboxy terminus of the novel mu opioid receptor splice variant MOR-1C within the human spinal cord.

    abstract::The present study examined the distribution in the human spinal cord of a unique carboxy terminus sequence contained within MOR-1C, one of the recently described splice variants of the cloned mu opioid receptor gene MOR-1. Although MOR-1-like immunoreactivity (LI) and delta opioid receptor-like immunoreactivity were o...


    pub_type: 杂志文章


    authors: Abbadie C,Gultekin SH,Pasternak GW

    更新日期:2000-06-26 00:00:00

  • Transcriptional regulation of the neuropeptide VGF by the neuron-restrictive silencer factor/neuron-restrictive silencer element.

    abstract::The neurotrophin-inducible gene VGF plays an important role in the maintenance of organismal energy balance and in the mediation of hippocampal synaptic activity. The regulatory mechanism of VGF transcription is not fully understood. The neuron-restrictive silencer factor (NRSF) binds with the neuron-restrictive silen...


    pub_type: 杂志文章


    authors: Moon SM,Kim JS,Park BR,Kim DK,Kim SG,Kim HJ,Chun HS,Lee BK,Kim CS

    更新日期:2015-02-11 00:00:00

  • Regeneration of the auditory pathway in adult rats by transplants of fetal brain tissue.

    abstract::The ventral cochlear tract in the brain stem to pons was transected on one side in two groups of adult rats. In one group simple transection was performed, while in the other group tissue from embryos (E14-E16) was used to cover the lesion site. While rats receiving simple transection without transplantation showed no...


    pub_type: 杂志文章


    authors: Ito J,Kawaguchi S,Murata M

    更新日期:1998-12-01 00:00:00

  • Disordered visual processing and oscillatory brain activity in autism and Williams syndrome.

    abstract::Two developmental disorders, autism and Williams syndrome, are both commonly described as having difficulties in integrating perceptual features, i.e. binding spatially separate elements into a whole. It is already known that healthy adults and infants display electroencephalographic (EEG) gamma-band bursts (around 40...


    pub_type: 临床试验,杂志文章


    authors: Grice SJ,Spratling MW,Karmiloff-Smith A,Halit H,Csibra G,de Haan M,Johnson MH

    更新日期:2001-08-28 00:00:00

  • Membrane-associated prostaglandin E synthase-1 is required for neuropathic pain.

    abstract::It is widely accepted that prostaglandin (PG) E2 is the principal pro-inflammatory prostanoid and plays an important role in inflammatory pain. However whether PGE2 is involved in neuropathic pain remains unknown. PGE2 is produced from arachidonic acid via PGH2 by at least three PGE synthases (PGES), cytosolic PGES (c...


    pub_type: 杂志文章


    authors: Mabuchi T,Kojima H,Abe T,Takagi K,Sakurai M,Ohmiya Y,Uematsu S,Akira S,Watanabe K,Ito S

    更新日期:2004-06-28 00:00:00

  • Hypoxia enhances the migration and invasion of human glioblastoma U87 cells through PI3K/Akt/mTOR/HIF-1α pathway.

    abstract::Widespread invasiveness, represented by the invasion and migration, is the most important characteristic of glioblastoma multiforme (GBM) and is the main reason for therapeutic failure and recurrence of the tumor. Hypoxia is one of the main microenvironment in determining tumor invasiveness. Therefore, intense efforts...


    pub_type: 杂志文章


    authors: Huang W,Ding X,Ye H,Wang J,Shao J,Huang T

    更新日期:2018-12-12 00:00:00

  • Source analysis of epileptic discharges using multiple signal classification analysis.

    abstract::Multiple signal classification is an alternative to the traditional dipole fitting source analysis methods. Our aim was to assess the clinical usefulness of this algorithm and to compare the localization of the epileptiform electroencephalography discharges with the regions of altered cerebral blood flow in 10 patient...


    pub_type: 杂志文章


    authors: Beniczky S,Oturai PS,Alving J,Sabers A,Herning M,Fabricius M

    更新日期:2006-08-21 00:00:00

  • Early emotional prosody perception based on different speaker voices.

    abstract::Decoding verbal and nonverbal emotional expressions is an important part of speech communication. Although various studies have tried to specify the brain regions that underlie different emotions conveyed in speech, few studies have aimed to specify the time course of emotional speech decoding. We used event-related p...


    pub_type: 杂志文章


    authors: Paulmann S,Kotz SA

    更新日期:2008-01-22 00:00:00

  • Lack of response to epidermal growth factor in adult neural progenitor cells.

    abstract::Neural progenitor/stem cells reside in the subventricular zone and dentate gyrus of the adult rat brain, which proliferate in response to several growth factors. Here we show that the neurospheres generated from the adult dentate gyrus and subventricular zone proliferate in vitro in response to fibroblast growth facto...


    pub_type: 杂志文章


    authors: Kalluri HS,Vemuganti R,Dempsey RJ

    更新日期:2005-05-31 00:00:00

  • Lower dopamine transporter binding potential in striatum during depression.

    abstract::Previous studies suggest that there is a dopamine lowering process during major depressive episodes (MDE). To investigate this, we measured the dopamine transporter binding potential (DAT BP) in the striatum of depressed and healthy subjects using [(11)C]RTI-32 PET. The DAT, a predominantly presynaptic receptor, decre...


    pub_type: 杂志文章


    authors: Meyer JH,Krüger S,Wilson AA,Christensen BK,Goulding VS,Schaffer A,Minifie C,Houle S,Hussey D,Kennedy SH

    更新日期:2001-12-21 00:00:00

  • Enhanced late components of AEFs associated with the temporal lobe lesions.

    abstract::We recorded auditory evoked magnetic fields (AEFs) by presenting pure tone bursts once every 4000 ms in 11 patients with a brain lesion in or in the vicinity of the auditory cortex. AEFs on the damaged side revealed several enhanced deflections in late-latency AEFs (slow AEFs), peaking at approximately 320 (DI), 1030 ...


    pub_type: 杂志文章


    authors: Kamada K,Takeuchi F,Harada T,Qiao B,Houkin K,Kuriki S,Iwasaki Y,Mitsumori K

    更新日期:2001-05-08 00:00:00

  • Grip force scaling after hemispatial neglect.

    abstract::Spatial neglect has been explained as an impairment in the representation of extrapersonal space. One account suggests that representations of extrapersonal space are spatially compressed following neglect. In support of this view it has been demonstrated that neglect patients systematically underestimate the size of ...


    pub_type: 杂志文章


    authors: Shaw A,Jackson SR,Harvey M,Newport R,Krämer T,Dow L

    更新日期:1997-12-01 00:00:00

  • Observing the touched body magnified alters somatosensory homunculus.

    abstract::This study aimed to investigate effects of observing the own body being touched on the functional topography of the somatosensory homunculus. We used neuromagnetic source imaging to map the topography in primary somatosensory cortex (SI) while manipulating the visibility of a touched hand. Participants were either abl...


    pub_type: 杂志文章


    authors: Schaefer M,Heinze HJ,Rotte M

    更新日期:2008-06-11 00:00:00

  • Intrastriatal DNQX induces rotation and pallidal Fos in the 6-OHDA model of Parkinson's disease.

    abstract::The 6-hydroxydopamine rat model of Parkinson's disease was combined with intracerebral drug infusions to examine the influence of glutamate receptors on striatal output activity. When infused into the dopamine-denervated striatum, the AMPA-kainate receptor antagonist DNQX dose-dependently elicited contralateral rotati...


    pub_type: 杂志文章


    authors: Schuller JJ,Marshall JF

    更新日期:1995-12-15 00:00:00

  • Glutamate agonist activity: implications for antipsychotic drug action and schizophrenia.

    abstract::Antagonist action at dopamine D2 receptors appears to explain many, but not all of the effects of antipsychotic drugs. Because of the interactions of dopamine with glutamate, and the implication of the latter in the etiology of schizophrenia, possible effects of antipsychotic drugs on glutamate receptors were assessed...


    pub_type: 杂志文章


    authors: Banerjee SP,Zuck LG,Yablonsky-Alter E,Lidsky TI

    更新日期:1995-12-15 00:00:00

  • Convulsant and anticonvulsant actions of agonists and antagonists of group III mGluRs.

    abstract::Group III metabotropic glutamate receptors (mGluR4, 6, 7, 8) are negatively coupled to adenylate cyclase and, when activated presynaptically, decrease the release of glutamate and GABA. We have used intracerebroventricular injections of agonists and antagonists believed to act selectively on these receptors to study t...


    pub_type: 杂志文章


    authors: Ghauri M,Chapman AG,Meldrum BS

    更新日期:1996-06-17 00:00:00

  • APOE and cerebral amyloid angiopathy in the elderly.

    abstract::Over 30% of normal elderly people have cerebral amyloid angiopathy (CAA). Possession of APOE epsilon4 is associated with increased prevalence and severity of CAA in Alzheimer's disease (AD) and in cerebral haemorrhage. We examined CAA in relation to APOE genotype in brains from 152 people aged 60-102 years, without AD...


    pub_type: 杂志文章


    authors: Love S,Nicoll JA,Hughes A,Wilcock GK

    更新日期:2003-08-06 00:00:00