Leptin in the nucleus accumbens blocks the increase of GluA1 phosphorylation induced by acute cocaine administration.

Abstract:

:Leptin in the rat's nucleus accumbens (NAcc) core has previously shown to disrupt the effects of acute administration of cocaine on both locomotor activity and the phosphorylation levels of glycogen synthase kinase 3β. In the present study, we further measured the phosphorylation levels of GluA1 after bilateral microinjections of leptin in this site followed by acute administration of cocaine. Interestingly, leptin in the NAcc core significantly blocks the increase of GluA1 phosphorylation levels at serine 845 induced by acute administration of cocaine. These effects were not observed for GluA1 phosphorylation levels at serine 831. We have also found additional evidence that glycogen synthase kinase 3β may play a major role in mediating these processes.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Lee JW,Kim WY,Kim JH

doi

10.1097/WNR.0000000000001001

subject

Has Abstract

pub_date

2018-04-11 00:00:00

pages

483-487

issue

6

eissn

0959-4965

issn

1473-558X

journal_volume

29

pub_type

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