Abstract:
:Leptin in the rat's nucleus accumbens (NAcc) core has previously shown to disrupt the effects of acute administration of cocaine on both locomotor activity and the phosphorylation levels of glycogen synthase kinase 3β. In the present study, we further measured the phosphorylation levels of GluA1 after bilateral microinjections of leptin in this site followed by acute administration of cocaine. Interestingly, leptin in the NAcc core significantly blocks the increase of GluA1 phosphorylation levels at serine 845 induced by acute administration of cocaine. These effects were not observed for GluA1 phosphorylation levels at serine 831. We have also found additional evidence that glycogen synthase kinase 3β may play a major role in mediating these processes.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Lee JW,Kim WY,Kim JHdoi
10.1097/WNR.0000000000001001subject
Has Abstractpub_date
2018-04-11 00:00:00pages
483-487issue
6eissn
0959-4965issn
1473-558Xjournal_volume
29pub_type
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