Abstract:
:We analysed the effects of morphine microinjections (0.2 microliter) into the subnucleus oralis (SNO), i.e. the rostral division of the spinal trigeminal nucleus, on the formalin test adapted for orofacial pain. Duration of rubbing following an injection (50 microliters) of formalin solution (1.5%) in the right upper lip of the rat was measured. Compared to microinjections of saline (NaCl, 0.9%) used as control, 90 and 180 nmol microliter-1 of morphine solution in the SNO significantly curtailed rubbing. This effect was dose-dependent, reversed by naloxone, and also site-specific to the SNO since no effect was observed after microinjection of morphine into areas adjacent to the SNO. These results are further evidence for the involvement of the SNO in perioral nociceptive mechanisms.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Luccarini P,Cadet R,Saade M,Woda Adoi
10.1097/00001756-199501000-00034subject
Has Abstractpub_date
1995-01-26 00:00:00pages
365-8issue
2eissn
0959-4965issn
1473-558Xjournal_volume
6pub_type
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