Abstract:
:The amino acid glycine is an inhibitory neurotransmitter in the spinal cord, brain stem, and vertebrate retina. The effective synaptic concentrations of glycine are regulated by at least two transporters: glycine transporter 1 and glycine transporter 2. Here, we show retinal expression of glycine transporter 1 by in-situ hybridization and of glycine transporter 2 by reverse transcriptase-PCR and in-situ hybridization. In-situ hybridization signals were observed in the ganglionar and inner nuclear layer as well as in the outer nuclear layer of the frog and rat retinas. In addition, accumulation of H-glycine was observed in isolated photoreceptor cells. The expression of these transporters in nonglycinergic cells suggests that they may also modulate electrical signals.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Peña-Rangel MT,Riesgo-Escovar JR,Sánchez-Chávez G,Salceda Rdoi
10.1097/WNR.0b013e32830a9618subject
Has Abstractpub_date
2008-08-27 00:00:00pages
1295-9issue
13eissn
0959-4965issn
1473-558Xpii
00001756-200808270-00009journal_volume
19pub_type
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