Glycine transporters (glycine transporter 1 and glycine transporter 2) are expressed in retina.

Abstract:

:The amino acid glycine is an inhibitory neurotransmitter in the spinal cord, brain stem, and vertebrate retina. The effective synaptic concentrations of glycine are regulated by at least two transporters: glycine transporter 1 and glycine transporter 2. Here, we show retinal expression of glycine transporter 1 by in-situ hybridization and of glycine transporter 2 by reverse transcriptase-PCR and in-situ hybridization. In-situ hybridization signals were observed in the ganglionar and inner nuclear layer as well as in the outer nuclear layer of the frog and rat retinas. In addition, accumulation of H-glycine was observed in isolated photoreceptor cells. The expression of these transporters in nonglycinergic cells suggests that they may also modulate electrical signals.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Peña-Rangel MT,Riesgo-Escovar JR,Sánchez-Chávez G,Salceda R

doi

10.1097/WNR.0b013e32830a9618

subject

Has Abstract

pub_date

2008-08-27 00:00:00

pages

1295-9

issue

13

eissn

0959-4965

issn

1473-558X

pii

00001756-200808270-00009

journal_volume

19

pub_type

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