Abstract:
:We previously reported that withdrawal from chronic cocaine produces supersensitivity of serotonin 2A receptors. We report here the minimum cocaine exposure necessary to produce withdrawal-associated increases in serotonin 2A receptor signaling in the frontal cortex. Rats withdrawn from cocaine treatments of 1, 3 or 7 days exhibited increases in G protein-stimulated and serotonin 2A receptor-stimulated phospholipase C activity in the frontal cortex. A single cocaine injection produced withdrawal-induced changes comparable to that produced by repeated exposure. None of these cocaine treatment paradigms are associated with changes in the levels of serotonin 2A receptors, Galphaq or Galpha11 proteins. These data demonstrate that only a single exposure to cocaine can produce unique withdrawal-associated neuroadaptations in serotonin 2A receptor signaling in the frontal cortex, which may be clinically relevant with respect to drug relapse.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Carrasco GA,Battaglia Gdoi
10.1097/01.wnr.0000246324.43567.55subject
Has Abstractpub_date
2007-01-08 00:00:00pages
51-5issue
1eissn
0959-4965issn
1473-558Xpii
00001756-200701080-00010journal_volume
18pub_type
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