Abstract:
:N-CAM-deficient mice display anatomical and electrophysiological abnormalities in the CNS and behavioral deficits. Here, we address the question whether information processing is altered in these mice by analysis of the expression of c-fos and arg 3.1/arc in N-CAM-deficient mice after presentation of saccharin as novel or familiar and water as neutral gustatory stimulus. When compared to their wild-type control littermates, increased expression of c-fos mRNA in the amygdala after the novel taste and of arg 3.1/arc mRNA in the dentate gyrus 4.5 h after the neutral taste was detected in the absence of N-CAM. Furthermore, the novelty-induced increase in arg 3.1/arc expression in the cingulate cortex 4.5 h after the novel taste was not observed in N-CAM-deficient mice. These data suggest that information processing mediated by immediate-early gene expression is altered in N-CAM-deficient mice.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Montag-Sallaz M,Montag D,Schachner Mdoi
10.1097/01.wnr.0000077549.91466.4csubject
Has Abstractpub_date
2003-07-18 00:00:00pages
1343-6issue
10eissn
0959-4965issn
1473-558Xjournal_volume
14pub_type
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