Abstract:
:We investigated the spatio-temporal brain activity on the time scale of several milliseconds related to the mental rotation task requiring judgements of hand orientation, using a whole-cortex MEG (magnetoencephalography) system. Neuronal activity in the visual cortex was observed approximately 100-200 ms from stimulus onset, and that in inferior parietal lobe followed (after 200 ms). Both of these activities showed a contralateral dominance to visual stimulus hemifield. Premotor activity started later than the inferior parietal lobe activity, and these activities partially overlapped. Activity in primary motor and/or motosensory areas was observed in some subjects. The whole-cortex neuromagnetic measurements provided the time course of activity in the human brain associated with the implicit motor imagery: visual cortex-->inferior parietal lobe<-->premotor cortex. This process is considered to be the transformation process of retinotopic locations into a body-centered reference frame necessary for the mental rotation task.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Kawamichi H,Kikuchi Y,Endo H,Takeda T,Yoshizawa Sdoi
10.1097/00001756-199804200-00031subject
Has Abstractpub_date
1998-04-20 00:00:00pages
1127-32issue
6eissn
0959-4965issn
1473-558Xjournal_volume
9pub_type
临床试验,杂志文章相关文献
NEUROREPORT文献大全abstract::N- and C-terminal substance P (SP) fragments increase striatal dopamine outflow at nanomolar concentrations. This contrasts with their low affinity for NK1 receptors. To explore this discrepancy, we investigated the interaction of SP and SP fragments with NK1 sites in fresh striatal slices, the same model used in the ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199907130-00038
更新日期:1999-07-13 00:00:00
abstract::Disturbances in methyl-carbon metabolism, which result in hyperhomocysteinemia, have been associated with schizophrenia. Homozygosity for the T677 allele of the methylenetetrahydrofolate reductase (MTHFR) gene, which encodes for a thermolabile enzyme associated with hyperhomocysteinemia, has been found to be increased...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199907130-00008
更新日期:1999-07-13 00:00:00
abstract::This study examined the effects of cocaine HCl and ambient temperature on the core body temperature of the rat. To further examine the mechanisms of cocaine-induced changes in temperature regulation, the effects of cocaine on behavioral thermoregulatory responses were also observed. At normal room temperature (20 degr...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199301000-00028
更新日期:1993-01-01 00:00:00
abstract::Prism adaptation reduces some symptoms of neglect; however the mechanisms underlying such changes are poorly understood. We suggest that prisms influence neglect by acting on dorsal stream circuits subserving visuomotor control, with little influence on perceptual aspects of neglect. We examined prism adaptation in th...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328338592f
更新日期:2010-04-21 00:00:00
abstract::Thyroid hormone receptor beta2 (TRbeta2) controls the patterning of cone opsin photopigments that mediate colour vision. We raised an antiserum against TRbeta2 to study cone photoreceptor development by western blot and immunostaining analyses. TRbeta2-positive cells first appeared between embryonic day 10 (E10) and E...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32832a2c63
更新日期:2009-04-22 00:00:00
abstract::The present study assessed the binding characteristics of [125I]angiotensin II to slices of human cerebellum adhered to glass slides using quantitative receptor autoradiography. Specific [125I]angiotensin II binding, defined by the inclusion of unlabelled angiotensin II (1.0 microM), was detected in the molecular laye...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199110000-00013
更新日期:1991-10-01 00:00:00
abstract::The effects of Alzheimer's disease-related beta-amyloid (Abeta) peptides on the N-methyl-D-aspartate (NMDA)-evoked cell firing rate were studied in hippocampal CA1 neurons of the rat. Extracellular single-unit recordings were combined with iontophoretic applications that allowed quantitative analyses of the interactio...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000134471.06244.d2
更新日期:2004-07-19 00:00:00
abstract::Traumatic brain injury (TBI) is a major risk factor for Alzheimer's disease. Recent studies suggest that amyloid-beta (Aβ) deposit can be detected several years after TBI. However, it is unknown whether post-TBI Aβ deposits arise from short-term changes in Aβ metabolism or reflect a long-term sequela. To answer this q...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000748
更新日期:2017-03-22 00:00:00
abstract::Complex tones such as vowels expressed by the human voice vary both in fundamental pitch (harmonic periodicity) and spectrum shape (vowel type). Three different pitches and spectra were combined into nine auditory stimuli. Latencies of cerebral evoked potential components decreased significantly as pitch increased, wh...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199603220-00014
更新日期:1996-03-22 00:00:00
abstract::Regulation of CNTF mRNA was investigated in primary cortical astrocytes cultured from newborn rats and in C6 glioma cells. Northern blot analysis indicated that semi-confluent astrocyte cell cultures. CNTF added to confluent astrocyte cultures down-regulated CNTF message in a dose-dependent fashion. In contrast, when ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199410000-00026
更新日期:1994-10-03 00:00:00
abstract::Episodic memory for simple commands is better following enacted than verbal encoding. This has been proposed to be due to the possibility to base retrieval on motor information. Here we used PET to test the hypothesis that motor brain areas show increased retrieval-related activity following enacted compared to verbal...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200007140-00027
更新日期:2000-07-14 00:00:00
abstract::Widespread invasiveness, represented by the invasion and migration, is the most important characteristic of glioblastoma multiforme (GBM) and is the main reason for therapeutic failure and recurrence of the tumor. Hypoxia is one of the main microenvironment in determining tumor invasiveness. Therefore, intense efforts...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001156
更新日期:2018-12-12 00:00:00
abstract::Scanning laser-Doppler flowmetry (SLDF) combines laser-Doppler flowmetry and laser scanning to provide images of cerebral blood flow (CBF) with high spatial and temporal resolution. We investigated the contribution of single vascular elements to the local increase of CBF accompanying increased neuronal activity in hal...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199911080-00002
更新日期:1999-11-08 00:00:00
abstract::I have investigated the role of Ca2+ on M-current (IK(M)) inhibition by the muscarinic agonist oxo-M using the perforated patch voltage clamp technique. Oxo-M inhibited IK(M) in cultured SCG cells with an IC50 of 1.2 microM in 2 mM [Ca2+]o, and 13.1 microM in nominally Ca(2+)-free external solution. BAPTA-AM, ryanodin...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199908020-00032
更新日期:1999-08-02 00:00:00
abstract::Huntingtin, the protein product of the Huntington's disease gene, associates with vesicle membranes and microtubules in neurons. Analysis of axonal transport with a stop-flow, double crush ligation approach in rat sciatic nerve showed that full length huntingtin (350 kDa) and an N-terminal cleavage product (50 kD) wer...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199707070-00031
更新日期:1997-07-07 00:00:00
abstract::Behavioral and neuropsychological studies suggest that upright and inverted face stimuli are processed by computationally and anatomically distinct systems. Specifically, inverted faces seem to be addressed by general object perception systems, avoiding face-specific processes. We tested this model by examining the fM...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00001756-199901180-00036
更新日期:1999-01-18 00:00:00
abstract::We screened proteins for interaction with presenilin (PS) 1, and cloned the full-length cDNA of human delta-catenin, which encoded 1225 amino acids. Yeast two-hybrid assay, GST binding assay and immunoprecipitation demonstrated that delta-catenin interacted with a hydrophilic loop region in the endoproteolytic C-termi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199902250-00022
更新日期:1999-02-25 00:00:00
abstract::We examined the effect of an AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole) antagonist, 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo (F) quinoxaline (NBQX), on rat cerebellar Purkinje cell loss and hippocampal pyramidal CA1 cell loss, after 10 minutes of global cerebral ischemia. NBQX was given intraperitoneally in a do...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199209000-00016
更新日期:1992-09-01 00:00:00
abstract::We examined differences in brain activity in response to two types of mechanical stimulation, which have been reported previously as being perceptually indistinguishable but having different impacts on autonomic reflexes. As an indicator of brain activity, glucose metabolism was evaluated by PET with 2-[F]fluoro-2-deo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32836164d4
更新日期:2013-05-29 00:00:00
abstract::Reading is a learned skill that is likely influenced by both brain maturation and experience. Functional imaging studies have identified brain regions important for skilled reading, but the structural brain changes that co-occur with reading acquisition remain largely unknown. We investigated maturational volume chang...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000121
更新日期:2014-03-26 00:00:00
abstract::Using NADPH-diaphorase (NADPH-d) staining as a marker for the enzyme nitric oxide synthase (NOS) we investigated the possible sites of nitric oxide (NO) synthesis in the olfactory pathways of an insect brain. Staining of frozen sections revealed NADPH-d activity in neurones and in glial cells. A cluster of intensely s...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199501000-00025
更新日期:1995-01-26 00:00:00
abstract::It has been hypothesized that the vomeronasal system (VNS), a complex neural network implicated in the control of reproductive behaviors, is sexually dimorphic. The posteromedial cortical amygdaloid nucleus (PMCo) belongs to the group of amygdaloid structures that receive direct olfactory input from the accessory olfa...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199808030-00042
更新日期:1998-08-03 00:00:00
abstract::The transmissible spongiform encephalopathies (TSEs) invariably result in fatal neurodegeneration and accumulation of PrP, an abnormal form of the host prion protein PrP, encoded by the PRNP gene. A naturally occurring polymorphism (methionine/valine) at PRNP codon 129 is associated with variation in relative disease ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282f1ca2f
更新日期:2007-12-03 00:00:00
abstract::This study examined 'prepulse inhibition' in the context of an auditory two-tone discrimination task performed by 15 healthy subjects. In order to distinguish between masking or excitatory information processes, weak acoustic pulses immediately preceded or succeeded a target or non-target tone in the discrimination. B...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199601310-00065
更新日期:1996-01-31 00:00:00
abstract::The role of dopamine D1A receptors in mediating amphetamine-induced sensitization was investigated using the D1A-deficient mouse. During the drug pre-exposure phase, D1A-deficient and control mice were injected for five consecutive days with saline or amphetamine (2 mg/kg, i.p.). Locomotor activity was measured on the...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199707280-00021
更新日期:1997-07-28 00:00:00
abstract::The distribution of GABA(B) receptor subunits GABA(B(1a)), GABA(B(1b)) and GABA(B2), has been examined in the cerebral cortex and thalamus of adult rats using an immunocytochemical technique. GABA(B(1a)) and GABA(B(1b)) subunits co-localized with GABA(B2) in the cortex, where afferent thalamic GABAergic axons project ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200103050-00032
更新日期:2001-03-05 00:00:00
abstract::The neurotrophin-inducible gene VGF plays an important role in the maintenance of organismal energy balance and in the mediation of hippocampal synaptic activity. The regulatory mechanism of VGF transcription is not fully understood. The neuron-restrictive silencer factor (NRSF) binds with the neuron-restrictive silen...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000316
更新日期:2015-02-11 00:00:00
abstract::An entry of Ca2+ into postsynaptic sites may play a role in the induction of long-term potentiation (LTP) of synaptic transmission in the visual cortex. To test this hypothesis, a Ca(2+)-chelator was injected into layer II/III neurons of sliced visual cortex obtained from young rats, and excitatory postsynaptic potent...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199009000-00018
更新日期:1990-09-01 00:00:00
abstract::The role of the right hemisphere in recovery of language function after left hemisphere stroke remains unclear. This prospective study aimed to determine the relationship between bilateral hemispheric changes and severity of aphasia in patients with chronic left hemisphere stroke. Twenty-three patients with left hemis...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000929
更新日期:2018-01-03 00:00:00
abstract::In previous studies, we demonstrated functional neuronal and dopaminergic differentiation of fetal mesencephalic neural precursor cells. The major factors for orienting their progeny towards a dopaminergic phenotype are forskolin and interleukin-1beta. Here, we investigated the effects of dexamethasone (10 microM) on ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000236862.08834.50
更新日期:2006-11-06 00:00:00