Abstract:
:S100B is a calcium-binding protein expressed and secreted by astrocytes, playing a neurotrophic role in neighboring cells. A protective role of the S100B against glutamate-induced excitotoxicity has recently been proposed. We investigated S100B secretion in rat hippocampal astrocytes exposed to high concentrations of glutamate during serum deprivation (stimulated condition) or not (basal condition), for 30 min. Glutamate at 1 mM had no effect on basal secretion of S100B, but it decreased S100B secretion in serum-deprived astrocytes after 1 h. Secretion was inhibited by Rp-cAMPS or H89. In addition, serum deprivation was accompanied by a transitory increase of intracellular content of cAMP. Our results suggest that high levels of glutamate in a serum-deprived condition could impair S100B secretion from hippocampal astrocytes.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Gonçalves D,Karl J,Leite M,Rotta L,Salbego C,Rocha E,Wofchuk S,Gonçalves CAdoi
10.1097/00001756-200208270-00009subject
Has Abstractpub_date
2002-08-27 00:00:00pages
1533-5issue
12eissn
0959-4965issn
1473-558Xjournal_volume
13pub_type
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