AMPA glutamate receptors and their flip and flop mRNAs in human hippocampus.

Abstract:

:AMPA-preferring glutamate receptor genes gluR1-4 undergo alternative splicing into flip and flop mRNA isoforms. In the rodent hippocampus, gluR1 and gluR2 isoforms are differentially expressed. We have studied their distribution in human hippocampus. As in the rat, flop isoforms predominate over flip in dentate gyrus, whereas gluR1 flip is prominent only in CA3. In contrast to the rat, flop mRNAs are clearly present in CA3. At a cellular level, pyramidal neurones express moderate amounts of each isoform. In several hippocampal fields, scattered non-pyramidal cells--putatively interneurones and glia--show abundant expression. The findings are supported by immunocytochemical detection of gluR1 and gluR2/3. As the four encoded isoforms have distinct properties, their differential expression within the hippocampus, and between species, should be taken into account when considering the roles of AMPA receptors in normal and abnormal brain states.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Eastwood SL,Burnet PW,Beckwith J,Kerwin RW,Harrison PJ

subject

Has Abstract

pub_date

1994-06-27 00:00:00

pages

1325-8

issue

11

eissn

0959-4965

issn

1473-558X

journal_volume

5

pub_type

杂志文章
  • Cue-induced renewal of heroin place preference: involvement of the basolateral amygdala.

    abstract::It is well established that re-exposure to a context paired with the effects of drugs of abuse can renew extinguished drug seeking behavior. A context, however, typically includes several stimuli, which may differ in their ability to control drug-oriented behaviors. Hence, the primary objective of this study was to as...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000084

    authors: Cummins E,Boughner E,Leri F

    更新日期:2014-03-26 00:00:00

  • Late developmental deficits in force control in children with hemiplegia.

    abstract::Differences related to development were investigated using a finger isometric force task in children with cerebral palsy and control children. The increase in force and force control observed in controls did not take place in patients. In the younger subset of patients (< 10 years) the force produced by the non-affect...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200408260-00020

    authors: Smits-Engelsman BC,Rameckers EA,Duysens J

    更新日期:2004-08-26 00:00:00

  • Neurometabolite changes in patients with complex regional pain syndrome using magnetic resonance spectroscopy: a pilot study.

    abstract::The aim of this study was to investigate distinct neurometabolites in the right and left thalamus and insula of patients with complex regional pain syndrome (CRPS) compared with healthy controls using proton magnetic resonance spectroscopy. Levels of N-acetylaspartate (NAA), N-acetylaspartylglutamate (NAAG), myo-inosi...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001168

    authors: Jung YH,Kim H,Jeon SY,Kwon JM,Kim YC,Lee WJ,Lee D,Lee JY,Moon JY,Kang DH

    更新日期:2019-01-16 00:00:00

  • Amyloid beta-peptide spin trapping. I: Peptide enzyme toxicity is related to free radical spin trap reactivity.

    abstract::Synthetic beta-amyloid peptides (A betas) demonstrate lot-to-lot variation in toxicity that has not been adequately explained. Studies from our laboratory have shown that A beta toxicity may result from the ability of the peptide to promote oxidation reactions. Both A beta(1-40) and A beta(25-35) inactivate the oxidat...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:

    authors: Hensley K,Aksenova M,Carney JM,Harris M,Butterfield DA

    更新日期:1995-02-15 00:00:00

  • Expression of activin receptors type I and II only partially overlaps in the nervous system.

    abstract::In situ hybridization was used to localize mRNA encoding two cooperative serine/threonine kinase receptors. Activin receptor IIA mRNA in the adult rat brain is highly expressed in the dentate gyrus, in the pyramidal neurones of CA3 and CA1, in the entorhinal cortex, in the cortical amygdaloid nucleus and in the amygda...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:

    authors: Bengtsson H,Söderström S,Ebendal T

    更新日期:1995-12-29 00:00:00

  • Benevolent sexism alters executive brain responses.

    abstract::Benevolence is widespread in our societies. It is defined as considering a subordinate group nicely but condescendingly, that is, with charity. Deleterious consequences for the target have been reported in the literature. In this experiment, we used functional MRI (fMRI) to identify whether being the target of (sexist...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3283625b5b

    authors: Dardenne B,Dumont M,Sarlet M,Phillips C,Balteau E,Degueldre C,Luxen A,Salmon E,Maquet P,Collette F

    更新日期:2013-07-10 00:00:00

  • Brain-based limitations in attention and secondary task engagement during high-fidelity driving simulation among young adults.

    abstract::Distracted driving remains a leading factor in fatal motor vehicle crashes, particularly in young drivers. Due to ongoing neuromaturation, attention capabilities are changing and improving throughout young adulthood. Here, we sought to bridge neuroscience with driving simulation by evaluating the effects of driving on...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001451

    authors: Banz BC,Wu J,Camenga DR,Mayes LC,Crowley MJ,Vaca FE

    更新日期:2020-05-22 00:00:00

  • Time course of brain activation elicited by basic emotions.

    abstract::Whereas facial emotion recognition protocols have shown that each discrete emotion has a specific time course of brain activation, there is no electrophysiological evidence to support these findings for emotional induction by complex pictures. Our objective was to specify the differences between the time courses of br...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000016

    authors: Hot P,Sequeira H

    更新日期:2013-11-13 00:00:00

  • Activation of kappa opioid receptors in the rostral ventromedial medulla blocks stress-induced antinociception.

    abstract::Prior work has shown that kappa opioids may attenuate the effects of analgesic mu receptor agonists in some neural circuits related to pain modulation. This study examined whether hypoalgesia following exposure to a signal for shock is attenuated by infusions of the kappa agonist U69593 into the rostral ventromedial m...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200010200-00017

    authors: Foo H,Helmstetter FJ

    更新日期:2000-10-20 00:00:00

  • Histamine H1 receptors are expressed in mouse and frog semicircular canal sensory epithelia.

    abstract::Histamine-related drugs are commonly used in the treatment of vertigo and related vestibular disorders. Their site and mechanism of action, however, are still poorly understood. To increase our knowledge of the histaminergic system in the vestibular organs, we have investigated the expression of H1 and H3 histamine re...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3282f76151

    authors: Botta L,Tritto S,Perin P,Laforenza U,Gastaldi G,Zampini V,Zucca G,Valli S,Masetto S,Valli P

    更新日期:2008-03-05 00:00:00

  • Induction of ischemic tolerance and antioxidant activity by brief focal ischemia.

    abstract::Three forms of non-injurious ischemic preconditioning were tested for their effects on endogenous antioxidant activity and subsequent ischemic injury. Test ischemia alone, consisting of 1 h occlusion of both carotid arteries (BCAs) and one middle cerebral artery (MCA), elicited an average volume of cerebral infarction...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199703030-00008

    authors: Toyoda T,Kassell NF,Lee KS

    更新日期:1997-03-03 00:00:00

  • Reading skill and structural brain development.

    abstract::Reading is a learned skill that is likely influenced by both brain maturation and experience. Functional imaging studies have identified brain regions important for skilled reading, but the structural brain changes that co-occur with reading acquisition remain largely unknown. We investigated maturational volume chang...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000121

    authors: Houston SM,Lebel C,Katzir T,Manis FR,Kan E,Rodriguez GG,Sowell ER

    更新日期:2014-03-26 00:00:00

  • LTD and LTP induced by transcranial magnetic stimulation in auditory cortex.

    abstract::Using a system capable of relatively localized and rapidrate transcranial magnetic stimulation (rTMS), evoked trains of complex spikes were studied in rodent auditory cortex. Low rate rTMS from 1 to 10Hz produced a frequency-dependent increase in spike rate. Iterations of rTMS resulted in long-term potentiation (LTP)-...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199601310-00035

    authors: Wang H,Wang X,Scheich H

    更新日期:1996-01-31 00:00:00

  • Brainstem microstimulation activates sympathetic fibers in pudendal nerve motor branch.

    abstract::A bilateral spino-bulbo-spinal circuit conveys information from/to the male urogenital tract and perineal muscles. This is the first electrophysiological report of another descending pathway, one which conveys output from the medullary reticular formation (MRF) to activate postganglionic sympathetic fibers contained w...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200002070-00031

    authors: Johnson RD,Hubscher CH

    更新日期:2000-02-07 00:00:00

  • Lesions of the pedunclopontine tegmental nucleus increase anxiety in rats.

    abstract::To test the hypothesis that the pedunclopontine tegmental nucleus (PPTg) plays a role in anxiety, rats with electrolytic lesions of the PPTg were tested in two animal models of anxiety, the elevated plus maze and the social interaction tests. Histological analysis showed that lesions were concentrated on the caudal ha...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199806010-00020

    authors: Podhorna J,Franklin KB

    更新日期:1998-06-01 00:00:00

  • Adenovirus-mediated gene transfer of Bcl-xL impedes neurite regeneration in vitro.

    abstract::Mouse retinal explants were transfected with recombinant adenovirus vector carrying the green fluorescent protein (GFP) gene and the rat bcl-x(L) gene (Adeno-Bcl-xL) to determine its ability to protect retinal ganglion cells against apoptotic cell death and to promote retinal ganglion cell neurite regeneration. Adeno-...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200306110-00011

    authors: Oshitari T,Okada S,Tokuhisa T,Adachi-Usami E

    更新日期:2003-06-11 00:00:00

  • Presenilin 1 interaction in the brain with a novel member of the Armadillo family.

    abstract::One approach to understanding the function of presenilin 1 (PS1), is to discover those proteins with which it interacts. Evidence for a function in developmental patterning came from C. elegans, in which a PS homologue was identified by screening for suppressors of a mutation in Notch/lin-12, a gene which specifies ce...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199704140-00033

    authors: Zhou J,Liyanage U,Medina M,Ho C,Simmons AD,Lovett M,Kosik KS

    更新日期:1997-04-14 00:00:00

  • Effects of adrenalectomy on hyperphagia induced by the 5-HT1A receptor agonist 8-OH-DPAT and 2-deoxy-D-glucose in rats.

    abstract::Effects of adrenalectomy on the 5-HT1A receptor agonist 8-hydroxy-2-di-n-(propylamino)tetralin (8-OH-DPAT)- and 2-deoxy-D-glucose (2-DG)-induced hyperphagia were investigated in rats. Prior adrenalectomy completely inhibited 2-DG-induced hyperphagia, although it did not affect increases in food intake elicited by 8-OH...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199806010-00030

    authors: Yamada J,Sugimoto Y,Yoshikawa T

    更新日期:1998-06-01 00:00:00

  • Impaired brain glucose metabolism in cirrhosis without overt hepatic encephalopathy: a retrospective 18F-FDG PET/CT study.

    abstract:OBJECTIVES:There are subclinical neurologic deficits in cirrhotic patients without overt hepatic encephalopathy. We aimed to use F-fluorodeoxyglucose PET/computed tomography to explore the impaired brain glucose metabolism of subclinical hepatic encephalopathy in cirrhosis. METHODS:Thirty-seven patients with hepatitis...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001284

    authors: Zhang W,Ning N,Li X,Li M,Duan X,Guo Y,Dang Y,Li Y,Gao J,Ye J,Yang J

    更新日期:2019-08-07 00:00:00

  • IL-10 down-regulates human microglial IL-8 by inhibition of NF-kappaB activation.

    abstract::In the present study, we tested the hypothesis that interleukin (IL)-10 down-regulates human microglial cell IL-8 release by inhibiting activation of nuclear factor kappa B (NF-kappaB). Immunohistochemical staining demonstrated that IL-10 markedly suppressed lipopolysaccharide (LPS)- and IL-1beta-stimulated IL-8 expre...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199806010-00010

    authors: Ehrlich LC,Hu S,Peterson PK,Chao CC

    更新日期:1998-06-01 00:00:00

  • Effects of Panax notoginseng saponin on α, β, and γ secretase involved in Aβ deposition in SAMP8 mice.

    abstract::Our previous studies have shown that Panax notoginseng saponins (PNS) play a protective role in learning dysfunction of Alzheimer's disease, inhibit the deposition of Aβ1-40 and Aβ1-42, and reduce the content of App in the brain of SAMP8. In this study, we aimed to investigate the effects of PNS on α, β, and γ secreta...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000048

    authors: Huang J,Wu D,Wang J,Li F,Lu L,Gao Y,Zhong Z

    更新日期:2014-01-22 00:00:00

  • Transneuronal viral labelling of rat heart left ventricle controlling pathways.

    abstract::Retrograde transneuronal viral labelling and immunocytochemical methods were used for revealing neuronal networks controlling the left ventricle myocardium of the rat heart. After injections of 1 microliter pseudorabies virus solution (3 x 10(6) PFU ml-1) into the left ventricle, infected orthosympathetic preganglioni...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199309150-00005

    authors: Ter Horst GJ,Van den Brink A,Homminga SA,Hautvast RW,Rakhorst G,Mettenleiter TC,De Jongste MJ,Lie KI,Korf J

    更新日期:1993-09-30 00:00:00

  • Is there a link between sleep changes and memory in Alzheimer's disease?

    abstract::Aging and Alzheimer's disease (AD) are both characterized by memory impairments and sleep changes. We investigated the potential link between these disturbances, focusing on sleep spindles, involved in memory consolidation. Two episodic memory tasks were given to young and old healthy participants, as well as to AD pa...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32830867c4

    authors: Rauchs G,Schabus M,Parapatics S,Bertran F,Clochon P,Hot P,Denise P,Desgranges B,Eustache F,Gruber G,Anderer P

    更新日期:2008-07-16 00:00:00

  • Combined event-related fMRI and EEG evidence for temporal-parietal cortex activation during target detection.

    abstract::Target detection is the process of bringing a salient stimulus into conscious awareness. Target detection evokes a prominent event-related potential (ERP) component (P3) in the electroencephalogram (EEG). We combined the high spatial resolution of functional magnetic resonance imaging (fMRI) with the high temporal res...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00001756-199709290-00007

    authors: Menon V,Ford JM,Lim KO,Glover GH,Pfefferbaum A

    更新日期:1997-09-29 00:00:00

  • Semantic sentence processing reflected in the event-related potentials of one- and two-year-old children.

    abstract::The present study used the N400, an electrophysiological correlate of semantic processing, to investigate 19- and 24-month-old children's ability to integrate the meaning of words in a sentential context. Children listened passively to semantically appropriate sentences and to sentences in which the object noun violat...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000185013.98821.62

    authors: Friedrich M,Friederici AD

    更新日期:2005-11-07 00:00:00

  • The role of precisely matching fascicles in the quick recovery of nerve function in long peripheral nerve defects.

    abstract::Peripheral nerve injury therapy in the clinic remains less than satisfactory. The gold standard of treatment for long peripheral nerve defects is autologous nerve grafts; however, numerous clinical complications are associated with this treatment. As tissue engineering has developed, tissue-engineered nerve grafts (TE...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000873

    authors: Yan L,Yao Z,Lin T,Zhu Q,Qi J,Gu L,Fang J,Zhou X,Liu X

    更新日期:2017-10-18 00:00:00

  • Altered hypothalamic functional connectivity patterns in major depressive disorder.

    abstract::The hypothalamus is a limbic structure involved in the emergence and persistence of major depressive disorder symptoms. Previous studies have indicated that major depressive disorder patients exhibited dysregulation between the hypothalamus and cerebral regions. However, it is still unclear about the exact hypothalami...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001335

    authors: Wang D,Xue SW,Tan Z,Wang Y,Lian Z,Sun Y

    更新日期:2019-11-06 00:00:00

  • Direct regulation of GnRH transcription by CRF-like peptides in an immortalized neuronal cell line.

    abstract::The existence of a CRF-dependent inhibition of GnRH transcription was investigated using a neuronal GnRH-expressing cell line (Gn11) stably transfected with mouse (-611 bp) or chicken (-3000 bp) GnRH promoter/luciferase reporter constructs. The presence of the CRF-R1 receptor was established using a specific CRF-R1 an...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199810050-00003

    authors: Tellam DJ,Perone MJ,Dunn IC,Radovick S,Brennand J,Rivier JE,Castro MG,Lovejoy DA

    更新日期:1998-10-05 00:00:00

  • Postnatal expression of thalamic GABAA receptor subunits in the stargazer mouse model of absence epilepsy.

    abstract::Absence seizures are known to originate from disruptions within the corticothalamocortical network; however, the precise underlying cellular and molecular mechanisms that induce hypersynchronicity and hyperexcitability are debated and likely to be complex and multifactorial. Recent studies implicate impaired thalamic ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000909

    authors: Seo S,Leitch B

    更新日期:2017-12-13 00:00:00

  • Persistence of CA1 hippocampal LTP after selective cholinergic denervation.

    abstract::The possible role of endogenous cholinergic innervation in hippocampal plasticity is controversial. We studied the role of acetylcholine (ACh) in short- and long-term potentiation (STP and LTP), using the cholinergic neurotoxin 192 IgG-saporin. It was still possible to induce STP the LTP in the CA1 field following com...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199603220-00024

    authors: Jouvenceau A,Billard JM,Lamour Y,Dutar P

    更新日期:1996-03-22 00:00:00