Abstract:
:Aging and Alzheimer's disease (AD) are both characterized by memory impairments and sleep changes. We investigated the potential link between these disturbances, focusing on sleep spindles, involved in memory consolidation. Two episodic memory tasks were given to young and old healthy participants, as well as to AD patients. Postlearning sleep was recorded. Sleep spindles were globally reduced in aging and AD. AD patients also exhibited a further decrease in fast spindles. Besides, mean intensity of fast spindles was positively correlated, in AD patients, with immediate recall performance. Our results are the first report of a specific decrease in fast spindles in AD, associated with learning abilities. They also give further hints for a functional differentiation between slow and fast spindles.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Rauchs G,Schabus M,Parapatics S,Bertran F,Clochon P,Hot P,Denise P,Desgranges B,Eustache F,Gruber G,Anderer Pdoi
10.1097/WNR.0b013e32830867c4subject
Has Abstractpub_date
2008-07-16 00:00:00pages
1159-62issue
11eissn
0959-4965issn
1473-558Xpii
00001756-200807160-00016journal_volume
19pub_type
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