Abstract:
:Cyclooxygenase (COX)-2 is constitutively expressed in the superficial dorsal horn of the spinal cord, but its role in the spinal cord is still unclear. We examined the effect of intrathecally administered NS398, a selective COX-2 inhibitor and indomethacin, an non-selective COX-1 and COX-2 inhibitor, on the development of thermal hyperalgesia induced by the activation of NMDA or AMPA receptors. Intrathecal injection of either NS398 or indomethacin equally blocked the development of thermal hyperalgesia induced by intrathecal injection of either NMDA or AMPA in a dose-dependent manner. These data suggest that COX-2 plays an important role in spinal thermal nociceptive transmission when neurons in the spinal cord are facilitated by NMDA or AMPA.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Yamamoto T,Sakashita Ydoi
10.1097/00001756-199812010-00019subject
Has Abstractpub_date
1998-12-01 00:00:00pages
3869-73issue
17eissn
0959-4965issn
1473-558Xjournal_volume
9pub_type
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