Abstract:
:Because salicylate is known to produce tinnitus in humans and animals, the effect of salicylate on the auditory system of gerbils was investigated using [14C]2-deoxyglucose (2-DG). Salicylate treatment reduced activity in the inferior colliculus (IC), particularly in the high frequency part, whereas activation along some isofrequency contours was observed in auditory cortex. In contrast, in saline-treated controls the IC but not the auditory cortex was active. These results suggest that the sensation of subjective tinnitus may be generated within auditory brain structures. The 2-DG method may be used to measure tinnitus objectively in animals and also to evaluate tinnitus treatments.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Wallhäusser-Franke E,Braun S,Langner Gdoi
10.1097/00001756-199607080-00010subject
Has Abstractpub_date
1996-07-08 00:00:00pages
1585-8issue
10eissn
0959-4965issn
1473-558Xjournal_volume
7pub_type
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