Lesion-induced right-hemispheric language and organization of nonverbal functions.


:Early left-hemispheric brain lesions may lead to a reorganization of language into the right hemisphere. Language functions are consecutively spared, but visuospatial functions show slight deficits. Cortical 'crowding' of the right hemisphere has been suggested as an explanation for this effect, but no direct evidence has as yet been put forward. We examined six patients with early left-hemispheric brain lesions and subsequent right-hemispheric language organization with functional magnetic resonance imaging and compared their activation patterns in a verbal and two nonverbal tasks with the patterns of six controls. In the patient group, nonverbal functions were reorganized neither interhemispherically nor intrahemispherically. Instead, verbal and nonverbal functions were mediated by a common right-hemispheric network. This argues in favour of the 'crowding hypothesis'.






Lidzba K,Staudt M,Wilke M,Grodd W,Krägeloh-Mann I




Has Abstract


2006-06-26 00:00:00














  • Somatotopic organization of the medial wall of the cerebral hemispheres: a 3 Tesla fMRI study.

    abstract::Somatotopic organization of the human medial wall of the cerebral hemispheres was studied using functional MRI conducted at high field strength (3 T) with fine spatial resolution ( approximately 2 mm). Healthy subjects performed paced, repetitive movements of the fingers and toes. Within the supplementary motor area (...


    pub_type: 杂志文章


    authors: Mayer AR,Zimbelman JL,Watanabe Y,Rao SM

    更新日期:2001-12-04 00:00:00

  • The beta-amyloid epitope masking activity in human brain is identified as albumin.

    abstract::Human brain homogenate proteins were analyzed for binding and processing activity in relation to brain beta-amyloid precursor protein (APP). The homogenate was purified by arginine-Sepharose 4B affinity chromatography, which traps proteins with affinity to certain groups of arginine residue, such as serine proteases a...


    pub_type: 杂志文章


    authors: Matsumoto A,Minami M,Matsumoto R

    更新日期:1997-10-20 00:00:00

  • MK-801, an NMDA receptor antagonist, in the rostroventromedial medulla attenuates development of neuropathic symptoms in the rat.

    abstract::Segmental ligation of spinal nerves in the rat induces a long-lasting hyperalgesia and allodynia that mimicks neuropathic conditions in humans. In the present study we attempted to determine whether supraspinal NMDA receptors contribute to the induction of the long-lasting hypersensitivity to noxious and innocuous mec...


    pub_type: 杂志文章


    authors: Wei H,Pertovaara A

    更新日期:1999-09-29 00:00:00

  • Neural correlates of the modified Stroop effect in post-traumatic stress disorder: an event-related potential study.

    abstract::Previous studies have provided electrophysiological evidence for attentional abnormalities in patients with post-traumatic stress disorder (PTSD). The present study examined the electrophysiological activity of trauma-exposed patients with or without a PTSD during a modified Stroop task. The PTSD group showed a reduce...


    pub_type: 杂志文章


    authors: Chen X,Wei D,Dupuis-Roy N,Du X,Qiu J,Zhang Q

    更新日期:2012-12-19 00:00:00

  • Hypoxia enhances the migration and invasion of human glioblastoma U87 cells through PI3K/Akt/mTOR/HIF-1α pathway.

    abstract::Widespread invasiveness, represented by the invasion and migration, is the most important characteristic of glioblastoma multiforme (GBM) and is the main reason for therapeutic failure and recurrence of the tumor. Hypoxia is one of the main microenvironment in determining tumor invasiveness. Therefore, intense efforts...


    pub_type: 杂志文章


    authors: Huang W,Ding X,Ye H,Wang J,Shao J,Huang T

    更新日期:2018-12-12 00:00:00

  • Inhibitory effect of zinc on hypoxic HIF-1 activation in astrocytes.

    abstract::Hypoxia-inducible factor-1 (HIF-1) regulates the expression of neuroprotective genes such as erythropoietin (EPO). We investigated the mechanism by which zinc, an excitotoxin-like metal, regulates HIF-1 under hypoxic conditions in astrocytes. In hypoxic LN215 cells, HIF-1alpha stabilized and accumulated in the nucleus...


    pub_type: 杂志文章


    authors: Kim I,Kim CH,Seo GH,Kim HS,Lee J,Kim DG,Ahn YS

    更新日期:2008-07-02 00:00:00

  • Maternal behavior: activation of the central oxytocin receptor system in parturient rats?

    abstract::Parturition plays a critical role in the full expression of maternal behavior in postpartum females, yet the precise mechanism remains unclear. Here we examined the role of parturition in the activation of Fos and FosB in the central oxytocin receptor (OTR) system in rats. Although expression of FosB, not Fos, was see...


    pub_type: 杂志文章


    authors: Lin SH,Kiyohara T,Sun B

    更新日期:2003-08-06 00:00:00

  • Involvement of phospholipase A2 in axonal regeneration of brain noradrenergic neurones.

    abstract::We have previously reported that antidepressants such as desipramine (DMI) induce axonal regeneration of brain noradrenergic neurons. In the present experiments, the role of phospholipase A2 (PLA2) in the regeneration of brain noradrenergic axons was studied. Symmetrical sites of the rat frontal cortex were pretreated...


    pub_type: 杂志文章


    authors: Nakamura S

    更新日期:1993-04-01 00:00:00

  • Lysine-specific demethylase 1 inhibitors protect cochlear spiral ganglion neurons against cisplatin-induced damage.

    abstract::Cisplatin is a widely used chemotherapeutic drug, but one of its side effects is ototoxicity. Epigenetic-related drugs, such as lysine-specific demethylase 1 (LSD1) inhibitors, have been reported to protect against cisplatin-induced hair cell loss by preventing demethylation of histone H3K4 (H3K4me2). However, the pro...


    pub_type: 杂志文章


    authors: Li A,He Y,Sun S,Cai C,Li H

    更新日期:2015-06-17 00:00:00

  • Disabling Gβγ-SNAP-25 interaction in gene-targeted mice results in enhancement of long-term potentiation at Schaffer collateral-CA1 synapses in the hippocampus.

    abstract::Three SNARE proteins, SNAP-25, syntaxin 1A, and VAMP2 or synaptobrevin 2, constitute the minimal functional machinery needed for the regulated secretion of neurotransmitters. Dynamic changes in the regulated release of neurotransmitters are associated with the induction of long-term plasticity at central synapses. In-...


    pub_type: 杂志文章


    authors: Irfan M,Zurawski Z,Hamm HE,Bark C,Stanton PK

    更新日期:2019-07-03 00:00:00

  • The intracellular fate of apolipoprotein E is tau dependent and apoe allele-specific.

    abstract::The apolipoprotein E (apoE) gene has been identified as a susceptibility gene for Alzheimer's disease, although the mechanism whereby apoE exerts this effect has not been determined. The aim of this study was to examine the intracellular fate of apoE and we demonstrate that in mammalian cells-transiently expressing ta...


    pub_type: 杂志文章


    authors: Lovestone S,Anderton BH,Hartley C,Jensen TG,Jorgensen AL

    更新日期:1996-04-10 00:00:00

  • N400 responses of children with primary language disorder: intervention effects.

    abstract::Event-related brain potentials were examined in 6 to 8-year-old children with primary language disorder before and after a 5-week narrative-based language intervention. Participants listened to sentences ending with semantically congruous or incongruous words. By comparison with typical controls, the children with pri...


    pub_type: 杂志文章


    authors: Popescu M,Fey ME,Lewine JD,Finestack LH,Popescu EA

    更新日期:2009-08-05 00:00:00

  • Impaired discrimination learning in interneuronal NMDAR-GluN2B mutant mice.

    abstract::Previous studies have established a role for N-methyl-D-aspartate receptor (NMDAR) containing the GluN2B subunit in efficient learning behavior on a variety of tasks. Recent findings have suggested that NMDAR on GABAergic interneurons may underlie the modulation of striatal function necessary to balance efficient acti...


    pub_type: 杂志文章


    authors: Brigman JL,Daut RA,Saksida L,Bussey TJ,Nakazawa K,Holmes A

    更新日期:2015-06-17 00:00:00

  • On the origin of Alzheimer's disease: a hypothesis.

    abstract::There is no unifying hypothesis to account for the anatomical distribution of neuropathology, the involvement of beta-amyloid precursor protein (beta APP) and the role of increasing age in triggering the Alzheimer disease process. We report here that layer II pre-alpha neurones in transentorhinal and entorhinal cortex...


    pub_type: 杂志文章


    authors: Roberts GW,Nash M,Ince PG,Royston MC,Gentleman SM

    更新日期:1993-01-01 00:00:00

  • Presynaptic exocytosis regulates NR2A mRNA expression in cultured neocortical neurones.

    abstract::N-methyl-D-aspartate (NMDA) receptors are hetero-oligomeric receptor-channel complexes composed of NR1 and NR2 subunits. Subunit composition determines the properties of NMDA receptor subtypes. However, the molecular mechanisms regulating their subunit composition are unknown. Using reverse transcription (RT)-competit...


    pub_type: 杂志文章


    authors: Hoffmann H,Hatt H,Gottmann K

    更新日期:1997-12-01 00:00:00

  • NMDA receptor subunit and CaMKII changes in rat hippocampus by congenital HCMV infection: a mechanism for learning and memory impairment.

    abstract::The aim of this study was to investigate the effects of congenital human cytomegalovirus infection on the expression levels of N-methyl-D-aspartate receptors (NRs) and Ca/calmodulin-dependent protein kinase II (CaMKII) in the hippocampal neurons of neonatal Sprague-Dawley (SD) rats. Pregnant SD rats were divided into ...


    pub_type: 杂志文章


    authors: Wu,Yang L,Bu X,Tang J,Fan X

    更新日期:2017-03-22 00:00:00

  • The behavioral effects of bilateral middle cerebral artery hemorrhagic ischemia in rat.

    abstract::After learning position discrimination in a T-maze water escape task, rats had either a 2 mm section of the middle cerebral artery removed bilaterally (bMCA) or they received a sham operation. Beginning on the day of surgery either total brain gangliosides (50 mg kg-1) or saline were administered daily for five days. ...


    pub_type: 杂志文章


    authors: McDaniel WF,Fjordbak T,Schmidt MS,Tucker JC,Davis BK

    更新日期:1991-11-01 00:00:00

  • Double-pulse stimulation dissociates intrathalamic and cortical high-frequency (>400Hz) SEP components in man.

    abstract::Human somatosensory evoked potentials (SEP) contain high-frequency (600 Hz) wavelet bursts possibly reflecting repetitive population spikes in thalamocortical axons and/or postsynaptic responses. To dissociate thalamic and cortical burst components the recovery of intrathalamic SEP (derived from electrodes implanted f...


    pub_type: 临床试验,杂志文章


    authors: Klostermann F,Funk T,Vesper J,Siedenberg R,Curio G

    更新日期:2000-04-27 00:00:00

  • Localization of NO synthase in rat brain by [3H]L-NG-nitro-arginine autoradiography.

    abstract::Nitric oxide (NO), a free radical gas that acts as a neural messenger, is produced from L-arginine by the enzyme nitric oxide synthase (NOS). The present study describes the autoradiographic localization throughout rat brain of the binding of [3H]L-NG-nitro-arginine ([3H]L-NOARG), a reversible NOS inhibitor, and confi...


    pub_type: 杂志文章


    authors: Burazin TC,Gundlach AL

    更新日期:1995-10-02 00:00:00

  • Grip force scaling after hemispatial neglect.

    abstract::Spatial neglect has been explained as an impairment in the representation of extrapersonal space. One account suggests that representations of extrapersonal space are spatially compressed following neglect. In support of this view it has been demonstrated that neglect patients systematically underestimate the size of ...


    pub_type: 杂志文章


    authors: Shaw A,Jackson SR,Harvey M,Newport R,Krämer T,Dow L

    更新日期:1997-12-01 00:00:00

  • Reproductive senescence predicts cognitive decline in aged female monkeys.

    abstract::The present investigation provide evidences from a non-human primate model that naturally occurring menopause predicts a prominent signature of age-related cognitive decline. Young and aged rhesus monkeys were tested on a delayed response (DR) task known to the sensitive to aging, and reproductive status was evaluated...


    pub_type: 杂志文章


    authors: Roberts JA,Gilardi KV,Lasley B,Rapp PR

    更新日期:1997-05-27 00:00:00

  • A magnetoencephalographic study of Japanese vowel processing.

    abstract::Magnetic brain responses were recorded to clarify the cortical representation of vowel processing in Japanese. We investigated the peak latencies and equivalent current dipoles of the auditory N1m responses to the Japanese vowels [a], [i], [o], and [u]. In intraindividual analyses for a single participant, well-replic...


    pub_type: 杂志文章


    authors: Ogata E,Yumoto M,Itoh K,Sekimoto S,Karino S,Kaga K

    更新日期:2006-07-31 00:00:00

  • Leucine-rich repeat kinase 2 G2385R variant is a risk factor for Parkinson disease in Asian population.

    abstract::To assess the effect of genetic factors on sporadic Parkinson disease, we performed a case-control study of a variant (G2385R) in Leucine-Rich Repeat kinase 2 among the Japanese population. The G2385R (c.7153G>A) variant was reported as a risk factor for sporadic Parkinson disease in the Chinese population from Taiwan...


    pub_type: 杂志文章


    authors: Funayama M,Li Y,Tomiyama H,Yoshino H,Imamichi Y,Yamamoto M,Murata M,Toda T,Mizuno Y,Hattori N

    更新日期:2007-02-12 00:00:00

  • Left minineglect or inverse pseudoneglect in children with dyslexia?

    abstract::This study compared the visuospatial asymmetries in children with dyslexia and healthy children by using the manual line bisection task, and investigated the processing of spatial context with a 'local' cueing paradigm consisting of geometric symbols placed on the extremities of the lines. The performance between heal...


    pub_type: 杂志文章


    authors: Michel C,Bidot S,Bonnetblanc F,Quercia P

    更新日期:2011-01-26 00:00:00

  • Immunohistochemical analysis on the role of adenosine A1 receptors in epilepsy.

    abstract::Adenosine has an anticonvulsant effect in various models of epilepsy. This effect appears to be mediated through the activation of adenosine A1 receptors (A1Rs). We immunohistochemically investigated the changes of A1Rs expression in kainate-treated and hippocampus-kindled rats as chronic models of epilepsy. In the no...


    pub_type: 杂志文章


    authors: Ochiishi T,Takita M,Ikemoto M,Nakata H,Suzuki SS

    更新日期:1999-11-26 00:00:00

  • Desensitizing GABAC receptors on carp retinal bipolar cells.

    abstract::Bicuculline- and baclofen-insensitive GABA receptors (GABAC receptors) on bipolar cells acutely dissociated from carp retina were investigated with using the whole-cell patch-clamp recording technique. The currents of these cells mediated by GABAC receptors showed striking desensitization, even at low concentrations o...


    pub_type: 杂志文章


    authors: Han MH,Li Y,Yang XL

    更新日期:1997-04-14 00:00:00

  • Time course and specificity of event-related potentials to emotional expressions.

    abstract::To clarify the time course of neural responses to faces with different emotional expressions, we used event-related potential (ERP) and reaction time measures. Faces expressing four different emotions (happy, neutral, fearful, disgusted) and houses were shown in both upright and inverted orientations while subjects pe...


    pub_type: 杂志文章


    authors: Ashley V,Vuilleumier P,Swick D

    更新日期:2004-01-19 00:00:00

  • Nitric oxide regulates NMDA-induced dopamine release in rat striatum.

    abstract::We investigated the effect of nitric oxide (NO) on N-methyl-D-aspartate (NMDA)-induced changes in levels of dopamine (DA) and its metabolite in the striatum using in vivo microdialysis. Local administration of 1mM NMDA into the striatum significantly augmented DA release in the striatum. Simultaneous administration of...


    pub_type: 杂志文章


    authors: Shibata M,Araki N,Ohta K,Hamada J,Shimazu K,Fukuuchi Y

    更新日期:1996-01-31 00:00:00

  • Macrocurrents of voltage gated Na+ and K+ channels from the crayfish stretch receptor neuronal soma.

    abstract::Currents from the slowly adapting stretch receptor neuron of the crayfish (Pacifastacus leniusculus) were studied in a cell attached configuration using patch pipettes with an opening diameter of 2-10 microm. The neuronal membrane was enzymatically freed from the glial layer. The voltage gated Na+ and K+ channels seem...


    pub_type: 杂志文章


    authors: Lin JH,Sand P,Rydqvist B

    更新日期:1999-08-20 00:00:00

  • DNA hypermethylation of the alpha synuclein promoter in patients with alcoholism.

    abstract::The aim of this study was to investigate whether the DNA methylation pattern within the alpha synuclein promoter region is altered in intoxicated and early abstinence patients with alcoholism undergoing alcohol withdrawal. We observed a significant increase of the alpha synuclein promoter DNA methylation in patients w...


    pub_type: 杂志文章


    authors: Bönsch D,Lenz B,Kornhuber J,Bleich S

    更新日期:2005-02-08 00:00:00