Abstract:
:We examined the biology of AMPA/kainate-induced motor neuron degeneration using dissociated spinal cord cultures and motor neuron-specific antibodies which enable characterization of individual motor neurons in culture. Cobalt, which is thought to pass through Ca2+-permeable AMPA/kainate receptors following kainate exposure, labeled motor neurons in spinal cord cultures. The analysis of AMPA subunit distribution in dissociated motor neurons revealed a unique pattern of glutamate receptor (GluR) subunits in those cells; the GluR1 subunit was found in all spinal cord neurons, but the GluR2 subunit was not found in identified dissociated motor neurons. These data suggest that selective sensitivity of motor neurons to non-NMDA receptor activation is due, at least in part, to the presence of Ca2+-permeable AMPA/kainate receptors.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Bar-Peled O,O'Brien RJ,Morrison JH,Rothstein JDdoi
10.1097/00001756-199903170-00034subject
Has Abstractpub_date
1999-03-17 00:00:00pages
855-9issue
4eissn
0959-4965issn
1473-558Xjournal_volume
10pub_type
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