Cultured motor neurons possess calcium-permeable AMPA/kainate receptors.

Abstract:

:We examined the biology of AMPA/kainate-induced motor neuron degeneration using dissociated spinal cord cultures and motor neuron-specific antibodies which enable characterization of individual motor neurons in culture. Cobalt, which is thought to pass through Ca2+-permeable AMPA/kainate receptors following kainate exposure, labeled motor neurons in spinal cord cultures. The analysis of AMPA subunit distribution in dissociated motor neurons revealed a unique pattern of glutamate receptor (GluR) subunits in those cells; the GluR1 subunit was found in all spinal cord neurons, but the GluR2 subunit was not found in identified dissociated motor neurons. These data suggest that selective sensitivity of motor neurons to non-NMDA receptor activation is due, at least in part, to the presence of Ca2+-permeable AMPA/kainate receptors.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Bar-Peled O,O'Brien RJ,Morrison JH,Rothstein JD

doi

10.1097/00001756-199903170-00034

subject

Has Abstract

pub_date

1999-03-17 00:00:00

pages

855-9

issue

4

eissn

0959-4965

issn

1473-558X

journal_volume

10

pub_type

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