Abstract:
:Voltage-gated sodium channels consist of a pore-containing alpha-subunit and one or more auxiliary beta-subunits, which may modulate channel function. We previously demonstrated that sodium channel SNS/PN3 alpha-subunits were decreased in human sensory cell bodies after spinal root avulsion injury, and accumulated at injured nerve terminals in pain states. Using specific antibodies for immunohistochemistry, we have now detected sodium channel beta1 and beta2 subunits in sensory cell bodies within control human postmortem sensory ganglia (78% of small/medium (< or = 50 microm) and 68% of large (> or = 50 microm) cells); their changes in cervical sensory ganglia after avulsion injury paralleled those described for SNS/PN3 alpha-subunits. Our results suggest that alpha- and beta-subunits share common regulatory mechanisms, but present distinct targets for novel analgesics.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Coward K,Jowett A,Plumpton C,Powell A,Birch R,Tate S,Bountra C,Anand Pdoi
10.1097/00001756-200103050-00012subject
Has Abstractpub_date
2001-03-05 00:00:00pages
483-8issue
3eissn
0959-4965issn
1473-558Xjournal_volume
12pub_type
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