Cells with a familial Alzheimer's disease mutation produce authentic beta-peptide.

Abstract:

:Cells overexpressing the beta-amyloid precursor protein possessing a mutation found in familial Alzheimer's disease overproduce beta-amyloid peptide (A beta). Because these findings were based on immunological identification, we have chemically characterized the peptides produced. Purified A beta fragments from the conditioned media of these cells were found to have N-terminal sequence consistent with the A beta found in cerebral plaques. Mass spectrometric data demonstrated a series of A beta fragments consistent with those found in Alzheimer's disease (AD); the major species corresponding to A beta(1-40). Significantly, a longer fragment corresponding to A beta(1-42) was found. These findings suggest that this cellular system may be useful for mechanistic studies of A beta generation and possibly for the development of therapeutic agents to treat AD.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Dovey HF,Suomensaari-Chrysler S,Lieberburg I,Sinha S,Keim PS

doi

10.1097/00001756-199308000-00011

subject

Has Abstract

pub_date

1993-08-01 00:00:00

pages

1039-42

issue

8

eissn

0959-4965

issn

1473-558X

journal_volume

4

pub_type

杂志文章
  • Functional imaging of brain activity in conscious monkeys responding to sexually arousing cues.

    abstract::Olfactory cues can elicit intense emotional responses. This study used fMRI in male common marmoset monkeys to identify brain areas associated with sexual arousal in response to odors of ovulating female monkeys. Under light anesthesia, monkeys were secured in a specially designed restrainer and positioned in a 9.4 T ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200107200-00037

    authors: Ferris CF,Snowdon CT,King JA,Duong TQ,Ziegler TE,Ugurbil K,Ludwig R,Schultz-Darken NJ,Wu Z,Olson DP,Sullivan JM Jr,Tannenbaum PL,Vaughan JT

    更新日期:2001-07-20 00:00:00

  • A functional MRI study of face recognition in patients with prosopagnosia.

    abstract::An fMRI investigation was conducted to determine whether patients with impaired face recognition, a deficit known as prosopagnosia, would show functional activation in the fusiform gyrus, the neural substrate for face processing, when viewing faces. While the patients did show activation in the fusiform gyrus, with si...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200106130-00014

    authors: Marotta JJ,Genovese CR,Behrmann M

    更新日期:2001-06-13 00:00:00

  • Involvement of progranulin in the enhancement of hippocampal neurogenesis by voluntary exercise.

    abstract::We have previously suggested that progranulin mediates the stimulatory effects of estrogen on adult neurogenesis in the hippocampus. Neurogenesis in mature animals is enhanced by growth factors, environmental enrichment, and voluntary exercise. In this study, we investigated the role of progranulin in voluntary runnin...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32834bf4ca

    authors: Asakura R,Matsuwaki T,Shim JH,Yamanouchi K,Nishihara M

    更新日期:2011-12-07 00:00:00

  • Rotation-induced conditioned rejection in the taste reactivity test.

    abstract::The taste reactivity test was used to evaluate the ability of motion sickness to produce conditioned rejection reactions, a putative measure of nausea in rats. Following three conditioning trials, rats displayed conditioned rejection reactions during an intraoral infusion of a rotation-paired saccharin solution. This ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199905140-00030

    authors: Cordick N,Parker LA,Ossenkopp KP

    更新日期:1999-05-14 00:00:00

  • No relation between 2D : 4D fetal testosterone marker and dyslexia.

    abstract::It has been suggested that high levels of prenatal testosterone exposure are implied in the aetiology of dyslexia and its frequently co-occurring sensory problems. This study examined 2D : 4D digit ratio (a marker of fetal testosterone exposure) in dyslexic and normal reading children. No group differences in 2D : 4D ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3282e9a754

    authors: Boets B,De Smedt B,Wouters J,Lemay K,Ghesquière P

    更新日期:2007-09-17 00:00:00

  • High-intensity interval training and moderate-intensity continuous training alleviate β-amyloid deposition by inhibiting NLRP3 inflammasome activation in APPswe/PS1dE9 mice.

    abstract::Recent study has demonstrated that high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) have the same effect to alleviate β-amyloid pathology in the hippocampus of APPswe/PS1dE9 (APP/PS1) mice. Activation of nucleotide binding and oligomerization domain-like receptor family pyrin d...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001429

    authors: Liang F,Huang T,Li B,Zhao Y,Zhang X,Xu B

    更新日期:2020-03-25 00:00:00

  • Neurone-specific enolase persists in some hippocampal cells 24 hours after an NMDA injection.

    abstract::Neurone-specific enolase immunoreactivity (NSE-IR) was examined in the hippocampal dentate gyrus 5 h, 24 h and 6 days following local injection of N-methyl-D-aspartate (NMDA), and was compared with Nissl substance and acid fuchsin staining. Five and 24 hours post-injection extracellular NSE-IR was increased, and the n...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199412000-00046

    authors: Comer AM,Lees GJ,Lipski J

    更新日期:1994-12-20 00:00:00

  • Late developmental deficits in force control in children with hemiplegia.

    abstract::Differences related to development were investigated using a finger isometric force task in children with cerebral palsy and control children. The increase in force and force control observed in controls did not take place in patients. In the younger subset of patients (< 10 years) the force produced by the non-affect...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200408260-00020

    authors: Smits-Engelsman BC,Rameckers EA,Duysens J

    更新日期:2004-08-26 00:00:00

  • Brain-based limitations in attention and secondary task engagement during high-fidelity driving simulation among young adults.

    abstract::Distracted driving remains a leading factor in fatal motor vehicle crashes, particularly in young drivers. Due to ongoing neuromaturation, attention capabilities are changing and improving throughout young adulthood. Here, we sought to bridge neuroscience with driving simulation by evaluating the effects of driving on...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001451

    authors: Banz BC,Wu J,Camenga DR,Mayes LC,Crowley MJ,Vaca FE

    更新日期:2020-05-22 00:00:00

  • Generalized presence of a PEC-60-like peptide in catecholamine neurones.

    abstract::PEC-60, a 60-residue intestinal peptide structurally related to the pancreatic secretory type of trypsin inhibitor, has been isolated, characterized and molecularly cloned. It shows biological activity as a hormone in both the gastrointestinal tract and in the immune system. We now report immunohistochemical evidence ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199409080-00033

    authors: Fuxe K,Tinner B,Metsis M,Staines W,Morassutti D,Agnati LF,Ostensson CG,Efendic S,Agerberth B,Goldstein M

    更新日期:1994-09-08 00:00:00

  • Sound perception affected by nonlinear variation of accuracy in memory trace.

    abstract::The mismatch negativity (MMN) reflects the neural representation of the acoustic environment stored in sensory memory. The short phase of sensory memory corresponds to the temporal window of integration (TWI) which integrates the neighboring sounds into a unitary event. We measured the magnetic MMN (MMNm) and the disc...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:

    authors: Yabe H,Asai R,Hiruma T,Sutoh T,Koyama S,Kakigi R,Tervaniemi M,Kaneko S

    更新日期:2004-12-22 00:00:00

  • Topographical differences in the trigeminal sensitivity of the human nasal mucosa.

    abstract::The aim of the study was to investigate differences in the distribution of intranasal trigeminal receptors in humans using an electrophysiological measure of trigeminally induced activation, the negative mucosa potential. A total of 29 young, healthy volunteers participated, results were on the basis of data from 18 p...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000224764.61959.e8

    authors: Scheibe M,Zahnert T,Hummel T

    更新日期:2006-09-18 00:00:00

  • Cerebral hemodynamics during electrically induced seizures.

    abstract::Electroconvulsive therapy (ECT) is an appropriate clinical model to investigate blood flow during seizures. In this study cerebral blood flow velocity (CBFV) was measured during 40 ECTs in 10 patients by means of transcranial Doppler sonography. EEG was recorded continuously. Under general anesthesia, the pre-convulsi...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章

    doi:10.1097/00001756-199802160-00009

    authors: Vollmer-Haase J,Folkerts HW,Haase CG,Deppe M,Ringelstein EB

    更新日期:1998-02-16 00:00:00

  • Astrocyte proliferation in culture following exposure to potassium ion.

    abstract::Following brain injury astrocytes swell acutely and proliferate thereafter. To investigate the direct relationship between swelling and proliferation, cultured astroglial cells were exposed to 60 mM K+ ion or hypo-osmolar (205 mOsm) electrolyte solution for 1 h to cause transient swelling. Proliferation was assessed b...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199401000-00027

    authors: Del Bigio MR,Omara F,Fedoroff S

    更新日期:1994-01-31 00:00:00

  • Restricted expression of latexin in dorsal midline cells of developing rat forebrain.

    abstract::Latexin is a novel 29 kDa protein which is expressed in a subpopulation of neurones in the lateral cerebral cortex of adult rats. Here, we report the distribution of immunohistochemically detectable latexin in the rat brain during early phases of development. Latexin was first detected at embryonic day 11 (E11) along ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199501000-00014

    authors: Takiguchi-Hayashi K,Arimatsu Y

    更新日期:1995-01-26 00:00:00

  • Amygdala depotentiation ex vivo requires mitogen-activated protein kinases and protein synthesis.

    abstract::We have recently characterized a form of ex vivo depotentiation (depotentiationex vivo), which correlates tightly with fear extinction, at thalamic input synapses onto the lateral amygdala. Here, we examined the effects of learning-attenuating drugs, reported to impair fear extinction when microinjected into the basol...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e328329412d

    authors: Kim J,Park S,Lee S,Choi S

    更新日期:2009-03-25 00:00:00

  • ErbB receptors modulation in different types of peripheral nerve regeneration.

    abstract::ErbBs are a family of receptors involved in the trophic maintenance of Schwann cells. Little is known about their expression changes during peripheral nerve regeneration. The aim of this study was thus to investigate variations in ErbBs after end-to-end and end-to-side nerve regeneration in the rat median nerve model....

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32831313ef

    authors: Audisio C,Nicolino S,Scevola A,Tos P,Geuna S,Battiston B,Perroteau I

    更新日期:2008-10-29 00:00:00

  • Metabotropic glutamate receptor mGluR2/3 immunoreactivity in the mouse superior colliculus: co-localization with calbindin D28K.

    abstract::We have studied the distribution of mGluR2/3 in the mouse superior colliculus (SC) with antibody immunocytochemistry and the effect of enucleation on this distribution. We also compared this labeling to that for calbindin D28K. Anti-mGluR2/3-immunoreactive (IR) cells formed distinctive laminar patterns within the lowe...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199904260-00034

    authors: Kim MA,Jeon CJ

    更新日期:1999-04-26 00:00:00

  • Endogenous radial glial cells support regenerating axons after spinal cord transection.

    abstract::During the development of central nervous system, radial glial cells support target-specific neuronal migration. We recently reported that after implantation of chitosan channels with complete spinal cord transection, the tissue bridging the spinal cord stumps contained axons and radial glial cells. The purpose of thi...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32833d9695

    authors: Nomura H,Kim H,Mothe A,Zahir T,Kulbatski I,Morshead CM,Shoichet MS,Tator CH

    更新日期:2010-09-15 00:00:00

  • Antinociceptive effect of morphine microinjections into the spinal trigeminal subnucleus oralis.

    abstract::We analysed the effects of morphine microinjections (0.2 microliter) into the subnucleus oralis (SNO), i.e. the rostral division of the spinal trigeminal nucleus, on the formalin test adapted for orofacial pain. Duration of rubbing following an injection (50 microliters) of formalin solution (1.5%) in the right upper ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199501000-00034

    authors: Luccarini P,Cadet R,Saade M,Woda A

    更新日期:1995-01-26 00:00:00

  • Long-term morphine treatment increases Ku protein DNA end-binding activity.

    abstract::Human neuroblastoma SH-SY5Y and small-cell lung carcinoma U1690 cells of neuroendocrine origin were exposed to morphine for 1 h, 3 h or 5 days. These treatments did not alter activities of AP-1, NF-kappa B and YY1 transcription factors in SH-SY5Y cells or NF-kappa B and YY1 in U1690 cells. Five-day morphine treatment,...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:

    authors: Bakalkin G,Yakovleva T,Melzig M,Terenius L

    更新日期:1997-07-07 00:00:00

  • Corticospinal projections from mesial frontal and cingulate areas in the monkey.

    abstract::We injected neural tracers into the lateral funiculus of the spinal cord in order to relate the sites of origin of the spinal projections from the mesial cortical surface with the cytoarchitectonic organization of this region. We found a close correlation between the origin sites and density of corticospinal projectio...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199412000-00035

    authors: Luppino G,Matelli M,Camarda R,Rizzolatti G

    更新日期:1994-12-20 00:00:00

  • Reading skill and structural brain development.

    abstract::Reading is a learned skill that is likely influenced by both brain maturation and experience. Functional imaging studies have identified brain regions important for skilled reading, but the structural brain changes that co-occur with reading acquisition remain largely unknown. We investigated maturational volume chang...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000121

    authors: Houston SM,Lebel C,Katzir T,Manis FR,Kan E,Rodriguez GG,Sowell ER

    更新日期:2014-03-26 00:00:00

  • Alpha-isoform of Ca2+/calmodulin-dependent kinase II autophosphorylation is required for memory consolidation-specific transcription.

    abstract::Autophosphorylation of the alpha-isoform of Ca2+/calmodulin-dependent kinase II switches the kinase into an autonomous activity mode. This molecular switch is important for hippocampal long-term memory formation, which requires de novo gene transcription and protein synthesis. Here, we have studied whether auto-phosph...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000175244.51084.bb

    authors: von Hertzen LS,Giese KP

    更新日期:2005-08-22 00:00:00

  • Event-related potential N270 correlates of brand extension.

    abstract::The aim of this study is to investigate the neural mechanism of extending a brand in a specific product category to other product categories. Facing two sequential stimuli in pairs consisting of beverage brand names (stimulus 1) and product names (stimulus 2) in other categories, 16 participants were asked to indicate...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3281667d59

    authors: Ma Q,Wang X,Dai S,Shu L

    更新日期:2007-07-02 00:00:00

  • Long-term sound conditioning increases distortion product otoacoustic emission amplitudes and decreases olivocochlear efferent reflex strength.

    abstract::The cochlea can be protected from acoustic trauma by moderate-level sound exposure. It is suggested that olivocochlear system may play a significant role in this protection. This study was performed to investigate distortion product otoacoustic emission (DPOAE) amplitudes changes and the efficiency of contralateral no...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32820049a8

    authors: Peng JH,Tao ZZ,Huang ZW

    更新日期:2007-07-16 00:00:00

  • Sex differences in functional activation patterns revealed by increased emotion processing demands.

    abstract::Two [O(15)] PET studies assessed sex differences regional brain activation in the recognition of emotional stimuli. Study I revealed that the recognition of emotion in visual faces resulted in bilateral frontal activation in women, and unilateral right-sided activation in men. In study II, the complexity of the emotio...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200402090-00001

    authors: Hall GB,Witelson SF,Szechtman H,Nahmias C

    更新日期:2004-02-09 00:00:00

  • Postnatal expression of thalamic GABAA receptor subunits in the stargazer mouse model of absence epilepsy.

    abstract::Absence seizures are known to originate from disruptions within the corticothalamocortical network; however, the precise underlying cellular and molecular mechanisms that induce hypersynchronicity and hyperexcitability are debated and likely to be complex and multifactorial. Recent studies implicate impaired thalamic ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000909

    authors: Seo S,Leitch B

    更新日期:2017-12-13 00:00:00

  • Astrocytes induce manganese superoxide dismutase in brain capillary endothelial cells.

    abstract::Astrocytes induce blood-brain barrier (BBB) properties in brain endothelial cells (EC)*O(2)*, generated in blood and EC, opens the BBB. Hence, high activity of superoxide dismutase (SOD) is a prerequisite for normal BBB function. Therefore, the influence of rat astrocytes on the expression of manganese (Mn)SOD in rat ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200108080-00045

    authors: Schroeter ML,Müller S,Lindenau J,Wiesner B,Hanisch UK,Wolf G,Blasig IE

    更新日期:2001-08-08 00:00:00

  • Mice are not little rats: species differences in a one-day water maze task.

    abstract::The present study examined species differences in spatial and non-spatial memory in the Morris water maze. Male Wistar rats and C57BL/6 mice were tested in a one-day water maze task in which spatial learning, retention, and non-spatial learning were assessed within 3 h. Rats and mice appeared to use different strategi...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200011090-00013

    authors: Frick KM,Stillner ET,Berger-Sweeney J

    更新日期:2000-11-09 00:00:00