Abstract:
:Cells overexpressing the beta-amyloid precursor protein possessing a mutation found in familial Alzheimer's disease overproduce beta-amyloid peptide (A beta). Because these findings were based on immunological identification, we have chemically characterized the peptides produced. Purified A beta fragments from the conditioned media of these cells were found to have N-terminal sequence consistent with the A beta found in cerebral plaques. Mass spectrometric data demonstrated a series of A beta fragments consistent with those found in Alzheimer's disease (AD); the major species corresponding to A beta(1-40). Significantly, a longer fragment corresponding to A beta(1-42) was found. These findings suggest that this cellular system may be useful for mechanistic studies of A beta generation and possibly for the development of therapeutic agents to treat AD.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Dovey HF,Suomensaari-Chrysler S,Lieberburg I,Sinha S,Keim PSdoi
10.1097/00001756-199308000-00011subject
Has Abstractpub_date
1993-08-01 00:00:00pages
1039-42issue
8eissn
0959-4965issn
1473-558Xjournal_volume
4pub_type
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