Abstract:
:The existence of a CRF-dependent inhibition of GnRH transcription was investigated using a neuronal GnRH-expressing cell line (Gn11) stably transfected with mouse (-611 bp) or chicken (-3000 bp) GnRH promoter/luciferase reporter constructs. The presence of the CRF-R1 receptor was established using a specific CRF-R1 antiserum. After 7 h of incubation, urotensin-I and sauvagine increased the mouse GnRH-reporter bioluminescence by 1.3- and 1.2-fold, respectively, compared with control cells. Subsequently, CRF, urotensin-I and sauvagine decreased luciferase reporter activity to about 60% of the control values after 14 h. Similar trends occurred with the chicken GnRH promoter with UI increasing reporter gene activity 2.4-fold over the controls after 14 h incubation. These data provide additional evidence for the direct regulation of GnRH transcription by CRF-like peptides.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Tellam DJ,Perone MJ,Dunn IC,Radovick S,Brennand J,Rivier JE,Castro MG,Lovejoy DAdoi
10.1097/00001756-199810050-00003subject
Has Abstractpub_date
1998-10-05 00:00:00pages
3135-40issue
14eissn
0959-4965issn
1473-558Xjournal_volume
9pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::In order to assess effects of glucagon-like peptide-1 (GLP-1) in the brain excluding the hypothalamus, the effects of GLP-1 (7-36) amide, a naturally produced active fragment, on the electroencephalogram and hippocampal single unit activities of anesthetized male Wistar rats were examined. I.c.v. injection of GLP-1 (7...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199906030-00004
更新日期:1999-06-03 00:00:00
abstract::For the majority of neurones in cat striate cortex, the response to an optimal stimulus presented to one eye is suppressed when a stimulus of substantially different orientation is presented to the other eye. In order to determine the true orientational tuning of the underlying inhibitory interactions in the absence o...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199511000-00032
更新日期:1995-11-13 00:00:00
abstract::Bone marrow stromal cells are multipotent stem cells that have the potential to differentiate into bone, cartilage, fat and muscle. Recently, bone marrow stromal cells have been shown to have the capacity to differentiate into neurons under specific experimental conditions, using chemical factors. We now describe how ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200504040-00017
更新日期:2005-04-04 00:00:00
abstract::Previous studies in adult rats have demonstrated that the neurotrophin, brain-derived neurotrophic factor (BDNF), is present in virtually all cells of the pituitary intermediate lobe. In the present study, we demonstrate that cells cultured from adult intermediate lobe pituitary (ILP) rapidly lose their BDNF immunorea...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199703240-00005
更新日期:1997-03-24 00:00:00
abstract::A bilateral spino-bulbo-spinal circuit conveys information from/to the male urogenital tract and perineal muscles. This is the first electrophysiological report of another descending pathway, one which conveys output from the medullary reticular formation (MRF) to activate postganglionic sympathetic fibers contained w...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200002070-00031
更新日期:2000-02-07 00:00:00
abstract::Complex tones such as vowels expressed by the human voice vary both in fundamental pitch (harmonic periodicity) and spectrum shape (vowel type). Three different pitches and spectra were combined into nine auditory stimuli. Latencies of cerebral evoked potential components decreased significantly as pitch increased, wh...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199603220-00014
更新日期:1996-03-22 00:00:00
abstract::Factors controlling proliferation and differentiation are crucial in advancement of neural cell-based experimental neurodegenerative therapies. In this regard, nicotinamide has been shown to determine the fate of neural cells, enhance neuralization, and influence DNA repair and apoptosis. This study investigated wheth...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000071
更新日期:2013-12-18 00:00:00
abstract::Plasminogen activator inhibitor-1 is a serpin that regulates the activities of plasminogen activators. However, its physiological roles in the CNS are incompletely understood. We have found that plasminogen activator inhibitor-1 has a novel biological function in the CNS: the contribution to survival of neurites on ne...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200404090-00024
更新日期:2004-04-09 00:00:00
abstract::We recorded event-related potentials (ERPs) in 2-month-old infants in two different states of alertness: awake and asleep. Syllables varying in vowel duration (long vs short) were presented in an oddball paradigm, known to elicit a mismatch brain response. ERPs of both groups showed a mismatch response reflected in a ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200207190-00006
更新日期:2002-07-19 00:00:00
abstract::Because of anecdotal reports in which ibogaine eliminates opioid withdrawal symptoms in humans, we studied this phenomenon in the rat model. Ibogaine (5, 10, 20 and 40 mg kg-1, s.c.) was administered 15 min before naloxone (0.5 mg kg-1, s.c.) in morphine dependent rats (3 days after the s.c. implantation of a 75 mg mo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199009000-00005
更新日期:1990-09-01 00:00:00
abstract::Experimental animals and patients are immobilized to allow continuous monitoring of physiological parameters. Restraint stress affects brain neurotransmitter levels and induces expression of immediate early genes. Whether immobilization stress affects outcomes in newborn animals which have suffered a hypoxic-ischaemic...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199601310-00025
更新日期:1996-01-31 00:00:00
abstract::Recent experiments have suggested that the process of visuomotor adaptation depends on how a visual distortion is introduced. The cerebellum is thought to be involved in adapting to rapidly introduced visual distortions; however its role in adapting to a gradually introduced distortion is unknown. We tested adaptation...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199904060-00025
更新日期:1999-04-06 00:00:00
abstract::Axons from central neurons can regenerate into the tissue matrix formed within a silicone tube capped with two pieces of peripheral nerve, one of which had been sutured to a lesion in the spinal cord. Such axons can grow through a transversely positioned microchip in the tube. These observations suggest that it is fea...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199803300-00018
更新日期:1998-03-30 00:00:00
abstract::It is well known that dendritic cells play a key role in producing antigen-specific responses. Inversely, tolerogenic dendritic cells (TolDCs), a specialized subset, induce immune tolerance and negatively regulate autoimmune responses. Statins, the inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the m...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000962
更新日期:2018-03-07 00:00:00
abstract::We studied the neural activation associated with the expectancy of emotional stimuli using whole brain fMRI. Fifteen healthy subjects underwent fMRI scanning during which they performed a warned reaction task using emotional pictures carrying pleasant, unpleasant, or neutral content. The task involved an expected or u...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200301200-00010
更新日期:2003-01-20 00:00:00
abstract::To study the penetration of magnesium ions from blood into brain tissue, magnesium content in serum and hippocampus of normal and of excitotoxically affected rats was estimated after a single subcutaneous injection of magnesium sulphate (600 mg kg-1). In normal rats Mg2+ levels in serum rose from 1 to 6 mM, while that...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199302000-00023
更新日期:1993-02-01 00:00:00
abstract::Microglia are activated by amyloid beta (Abeta) in vivo and in vitro, and Abeta-activated microglia may be involved in the pathogenesis of Alzheimer's disease (AD). We investigated the mechanism of microglial chemotaxis induced by Abeta (25-35), an active fragment of Abeta. Abeta (25-35) 0.1 and 1 nM stimulated microg...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199810260-00024
更新日期:1998-10-26 00:00:00
abstract::Single-pulse unilateral electrical stimulation of either the amygdala or the inferior colliculus elicited startle-like responses in chloral hydrate anesthetized rats. EMG responses to intracranial stimulation were recorded from the anterior biceps femoris muscles. The EMG responses were generally enhanced following un...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200210070-00015
更新日期:2002-10-07 00:00:00
abstract::The so-called 40 Hz oscillations are found at almost all stages of visual processing are thought to play a critical role in perception. The goal of this investigation was to look at the presence of stimulus-specific oscillations in the lateral posterior-pulvinar complex of the thalampus (LP-P) for which the oscillatio...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199511270-00017
更新日期:1995-11-27 00:00:00
abstract::Cells overexpressing the beta-amyloid precursor protein possessing a mutation found in familial Alzheimer's disease overproduce beta-amyloid peptide (A beta). Because these findings were based on immunological identification, we have chemically characterized the peptides produced. Purified A beta fragments from the co...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199308000-00011
更新日期:1993-08-01 00:00:00
abstract::Cyclooxygenase (COX)-2 is constitutively expressed in the superficial dorsal horn of the spinal cord, but its role in the spinal cord is still unclear. We examined the effect of intrathecally administered NS398, a selective COX-2 inhibitor and indomethacin, an non-selective COX-1 and COX-2 inhibitor, on the developmen...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199812010-00019
更新日期:1998-12-01 00:00:00
abstract::The reduced steroids 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone) and 3 alpha,21-di-hydroxy-5 alpha-pregnan-20-one (allotetrahydroDOC) are potent ligands of GABAA receptors. This study examined the possible modulatory effect of these metabolites on GABA inhibition of somatostatin release in cultured hypot...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199510020-00025
更新日期:1995-10-02 00:00:00
abstract::The Stroop effect refers to an increase in response time observed when the word meaning and the stimulus hue do not match. In an incongruent condition, the word 'green' is presented in the color red, whereas in a congruent condition the word 'red' is presented in the color red. To determine at what level of processing...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32832a0a10
更新日期:2009-05-06 00:00:00
abstract::Recent studies have discussed the role of the cerebellum in not only motor but also cognitive functions, and in particular, fronto-executive operations. Similar to a previous study on hemineglect patients, we recorded eye movements during a visual search task to investigate patients with isolated infarction of the cer...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000177015.75096.b6
更新日期:2005-09-08 00:00:00
abstract::In line with a possible role of vergence in orienting visual attention, we sought to study this eye movement in young children to provide insights on face perception. For this purpose, we measured the modulation in the angle of eye vergence in a sample of 39 children aged 6-36 months and compared it when presenting st...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000963
更新日期:2018-02-07 00:00:00
abstract::Oculopharyngeal muscular dystrophy (OPMD) is an autosomal dominant muscular dystrophy characterized by late onset ptosis, proximal muscle weakness and swallowing difficulties. This disease has been recently linked to chromosome 14q11.2-q13 in French-Canadian pedigrees. We studied three unrelated American families with...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199804200-00002
更新日期:1998-04-20 00:00:00
abstract::Oscillatory activity is a ubiquitous property of brain signals, and yet relatively few studies have investigated how the phase of such ongoing oscillations affects our cognition. One of the main findings in this field is that the phase of electroencephalography (EEG) in the alpha band can affect perception of millisec...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001215
更新日期:2019-04-10 00:00:00
abstract::Using functional magnetic resonance imaging, we explored the role of semantics in mediating orthographic-to-phonological processing in reading aloud, focusing on the interaction of imageability with spelling-to-sound consistency for low-frequency words. Behaviorally, high-imageable words attenuate the standard latency...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200504250-00021
更新日期:2005-04-25 00:00:00
abstract::It is not clear whether attention is necessary or not for consciousness. We studied the relationship between attention and consciousness by tracking their electrophysiological correlates. The participants attended to visual targets, ignored nontargets in the prespecified visual field and ignored all stimuli in the opp...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3280c143c8
更新日期:2007-05-28 00:00:00
abstract::Prefrontal delay-period activity represents a neural mechanism for the active maintenance of information and needs to be controlled by some signal to appropriately operate working memory. To examine whether reward-delivery acts as this signal, the effects of delay-period activity in response to unexpected reward-deliv...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32833776a3
更新日期:2010-03-31 00:00:00