Abstract:
:Recent studies have discussed the role of the cerebellum in not only motor but also cognitive functions, and in particular, fronto-executive operations. Similar to a previous study on hemineglect patients, we recorded eye movements during a visual search task to investigate patients with isolated infarction of the cerebellum compared with controls. Patients showed longer search durations, associated with mild saccadic dysmetria, longer single fixation durations and a higher number of repeated fixations of items. Systematic search strategies were preserved, but less frequent in patients. In conclusion, though basic mechanisms of visual search including spatial memory were not affected by cerebellar lesions, patients' search behaviour was slower and less efficient, indicating a mild deficit of visual attention and motor planning.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Machner B,Sprenger A,Kömpf D,Heide Wdoi
10.1097/01.wnr.0000177015.75096.b6subject
Has Abstractpub_date
2005-09-08 00:00:00pages
1507-11issue
13eissn
0959-4965issn
1473-558Xpii
00001756-200509080-00020journal_volume
16pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::We used whole-cell recording to identify, for the first time, GABAergic tonic current in subpopulations of substantia gelatinosa neurons in mouse spinal cord slices. Application of the gamma-aminobutyric acid type A receptor antagonist bicuculline revealed tonic currents in 49 of 73 substantia gelatinosa neurons. Thes...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000230515.86090.bc
更新日期:2006-08-21 00:00:00
abstract::Axotomy-induced death of corticospinal neurons (CSN) is prevented by intracotrical infusions of BDNF or NT-3 within the first week after axotomy. The present study examined whether this represents merely a delay of CSN death or whether BDNF and NT-3 can promote long-term survival of these neurons in vivo. The neurotro...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199908200-00043
更新日期:1999-08-20 00:00:00
abstract::Gastrin-releasing peptide plays an important role in regulating the advanced functions of the brain including emotional behavior, learning and memory. What's more, gastrin-releasing peptide levels are also associated with the central nervous system diseases. Our previous study proposed that intraperitoneal injection o...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001324
更新日期:2019-10-16 00:00:00
abstract::This study tested the hypothesis that inhibition of nitric oxide synthase (NOS) in the medial pontine reticular formation (mPRF) would cause decreased acetylcholine (ACh) release. Microdialysis of cat mPRF permitted measurement of ACh during states of wakefulness, non-rapid eye movement (NREM) sleep and rapid eye move...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199507310-00015
更新日期:1995-07-31 00:00:00
abstract::The present study examined the effect of peripherally applied morphine and GABA on jaw muscle electromyographic activity reflexly evoked by co-injection of glutamate into the temporomandibular joint (TMJ) of lightly anesthetized Sprague-Dawley rats of both sexes. In male but not female rats, morphine significantly sup...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200111160-00016
更新日期:2001-11-16 00:00:00
abstract:OBJECTIVES:There are subclinical neurologic deficits in cirrhotic patients without overt hepatic encephalopathy. We aimed to use F-fluorodeoxyglucose PET/computed tomography to explore the impaired brain glucose metabolism of subclinical hepatic encephalopathy in cirrhosis. METHODS:Thirty-seven patients with hepatitis...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001284
更新日期:2019-08-07 00:00:00
abstract::We aimed to ascertain whether pyrethroid insecticides could influence the vesicular transport of the excitatory amino acid glutamate. The incubation of rat cortical synaptic vesicles with resmethrin and permethrin, consistently stimulated both ATP-dependent and -independent uptake of [3H]glutamate, while not evoking d...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199810260-00034
更新日期:1998-10-26 00:00:00
abstract::Previous studies in adult rats have demonstrated that the neurotrophin, brain-derived neurotrophic factor (BDNF), is present in virtually all cells of the pituitary intermediate lobe. In the present study, we demonstrate that cells cultured from adult intermediate lobe pituitary (ILP) rapidly lose their BDNF immunorea...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199703240-00005
更新日期:1997-03-24 00:00:00
abstract::Interleukin-6 (IL-6) is a proinflammatory cytokine known to modulate neurogenesis. We presently evaluated neural progenitor proliferation, survival, and phenotypic maturation in the hippocampal dentate gyrus, subventricular zone, and the posterior periventricle in the brains of IL-6 knockout mice and their wild-type l...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283430a44
更新日期:2011-02-16 00:00:00
abstract::The protein p42(IP4) (also called centaurin alpha), identified as a brain-specific InsP4/PtdInsP3 (PIP3)-binding protein, has been shown to be localized in human brain, specifically expressed in neurons. Several casein kinases have been found to be involved in Alzheimer's disease (AD) pathology. Since casein kinase I ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200212200-00008
更新日期:2002-12-20 00:00:00
abstract::Limbic event-related potentials related to verbal but not to visual recognition memory have been found to be attenuated within the epileptic hippocampus of patients with temporal lobe epilepsy (TLE). To identify hippocampal contributions to visual processing and memory we recorded intracranial ERPs directly from withi...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-200308060-00017
更新日期:2003-08-06 00:00:00
abstract::This study compared the visuospatial asymmetries in children with dyslexia and healthy children by using the manual line bisection task, and investigated the processing of spatial context with a 'local' cueing paradigm consisting of geometric symbols placed on the extremities of the lines. The performance between heal...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328342d2df
更新日期:2011-01-26 00:00:00
abstract::The environment in which cocaine is experienced becomes associated with the effects of the drug and can then elicit cocaine craving. This study examined whether the hippocampus is involved in such associations using the conditioned place preference model. Rats received bilateral lesions of the dorsal or ventral hippoc...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200311140-00023
更新日期:2003-11-14 00:00:00
abstract::Pyramidal cells were injected intracellularly in fixed, flat-mounted cortical slices taken from the first and fourth visual areas (V1 and V4, respectively) and cytoarchitectonic areas TEO and TE of two age and gender-matched vervet monkeys and the size, branching complexity and spine density of their basal dendritic t...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200506210-00017
更新日期:2005-06-21 00:00:00
abstract::Stimulation of the Schaffer collateral projection to the CA1 region in rat hippocampal slices at 1 Hz for 15 min produced a N-methyl-D-aspartate (NMDA) receptor-dependent long-term depression (LTD) of synaptic responses and, when given after tetanic stimulation, reversed long-term potentiation (LTP). Both LTD and the ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
abstract::The effect of centrally administered bombesin on core temperature was investigated in rats which had been chronically fitted with a cannula in the third cerebral ventricle and with an intraperitoneal temperature-monitoring radiotransmitter. Intracerebroventricularly administered bombesin (0.01, 0.1 or 1 microgram) res...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199403000-00026
更新日期:1994-03-21 00:00:00
abstract::The expression pattern of metabotropic glutamate receptor 1alpha (mGluR1alpha) was immunohistochemically investigated in substantia nigra dopaminergic neurons of the macaque monkey. In normal monkeys, mGluR1alpha immunoreactivity was weakly observed in the dorsal tier of the substantia nigra pars compacta (SNc-d) wher...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000074344.81633.e4
更新日期:2003-05-23 00:00:00
abstract::Alopecia areata (AA) is a dermatosis involving the sudden occurrence of bald patches on the scalp. Although the aetiology is unknown, experimental data indicate that cutaneous microcirculation plays an important role. The skin is richly innervated by neuropeptidergic sensory nerves that help regulate microvascular cir...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199703240-00015
更新日期:1997-03-24 00:00:00
abstract::Absence seizures are known to originate from disruptions within the corticothalamocortical network; however, the precise underlying cellular and molecular mechanisms that induce hypersynchronicity and hyperexcitability are debated and likely to be complex and multifactorial. Recent studies implicate impaired thalamic ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000909
更新日期:2017-12-13 00:00:00
abstract::Multiple regression voxel-based morphometry analyses were used to examine the relationship between regional gray matter volumes and neurocognitive performance in 10 patients with amnestic mild cognitive impairment and 20 healthy age-matched controls. Cognitive functioning was assessed with seven standardized neuropsyc...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328335642a
更新日期:2010-03-10 00:00:00
abstract::Adrenocorticotropic hormone (ACTH) is a member of the opiocortin family of peptides. Within the central nervous system, ACTH-synthesizing neurons are generally considered to be located within the hypothalamus and are known to be involved in the neural circuitry underlying the integration of stress responses. We now re...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199202000-00001
更新日期:1992-02-01 00:00:00
abstract::Light physiologically regulates the levels of c-Fos in the suprachiasmatic nucleus (SCN), but the identity of most of the cells that express this DNA-binding protein is unknown. To determine whether SCN c-Fos expression is restricted to neurons, we performed light microscopic double-label immunohistochemistry on secti...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199409080-00012
更新日期:1994-09-08 00:00:00
abstract::The aim of this study was to examine the neurodegenerative effects of intraventricular colchicine on granule cells of the hippocampal dentate gyrus and to characterise the modality of neuronal cell death. Male Sprague-Dawley rats were killed 24 hours after a single injection of colchicine into the third ventricle and ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199712010-00025
更新日期:1997-12-01 00:00:00
abstract::Inherited retinal degenerations such as retinitis pigmentosa (RP) are characterized by progressive loss of photoreceptors, apparently by apoptosis, and our recent report of increased secreted Frizzled-related protein-2 (SFRP2) in RP retinas suggests altered Wnt signalling may be a component of the degenerative process...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200012180-00012
更新日期:2000-12-18 00:00:00
abstract::Cyclin-dependent kinases (CDK) mediate the cell division cycle during G1 phase and CDK inhibitors negatively regulate the cell cycle. We investigated expression of the CDK inhibitor p27Kip1 and the effects of PI-3K/Akt on proliferation of progenitors in the subventricular zone of adult rat. Western blots and immunosta...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000135693.81613.cc
更新日期:2004-08-06 00:00:00
abstract::The conditioned place preference (CPP) induced by cocaine 2.5 mg/kg was measured in rats pre-exposed to ethanol (14 days with only 10% v/v ethanol followed by a free choice between ethanol solution and water for 14 days). Rats were divided according to their alcohol intake during the free choice period into low-drinki...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199808240-00038
更新日期:1998-08-24 00:00:00
abstract::Studies in zebra finches failed to demonstrate the involvement of the NIf, a higher-order song nucleus afferent to the HVc, in the production of learned song. The song of the Bengalese finch, a related species, has a higher level of temporal organization; multiple song phrases are organized into a song. We hypothesize...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200007140-00007
更新日期:2000-07-14 00:00:00
abstract::Recent experiments have suggested that the process of visuomotor adaptation depends on how a visual distortion is introduced. The cerebellum is thought to be involved in adapting to rapidly introduced visual distortions; however its role in adapting to a gradually introduced distortion is unknown. We tested adaptation...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199904060-00025
更新日期:1999-04-06 00:00:00
abstract::In order to accomplish desired movements, the nervous system must specify the movement dynamics: it must provide a signal that compensates for the mechanical constraints encountered during movement. Here we tested whether the population activity of Purkinje cells in the cerebellum specifies the dynamics for pursuit ey...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200004070-00029
更新日期:2000-04-07 00:00:00
abstract::Latest reports suggest the involvement of insulin in modulating memory. A few published in-vitro studies favor the antidementia effect of insulin. Thus, the present study aimed to evaluate the prophylactic role of insulin and its combination with glucose and its possible mechanism(s) in an aluminum chloride (AlCl3)-in...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000799
更新日期:2017-06-14 00:00:00