Abstract:
:The effect of centrally administered bombesin on core temperature was investigated in rats which had been chronically fitted with a cannula in the third cerebral ventricle and with an intraperitoneal temperature-monitoring radiotransmitter. Intracerebroventricularly administered bombesin (0.01, 0.1 or 1 microgram) resulted in hypothermia, the duration and depth of the effect being a function of the dose. The use of telemetry minimized experimental interventions in this study; the results demonstrate that the hypothermic response to bombesin is not dependent upon exposure to a low ambient temperature, food restriction or insulin treatment as suggested by previous studies involving measurement of core temperature by a rectal probe.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Persaud RA,Coen CWdoi
10.1097/00001756-199403000-00026subject
Has Abstractpub_date
1994-03-21 00:00:00pages
841-3issue
7eissn
0959-4965issn
1473-558Xjournal_volume
5pub_type
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