Abstract:
:Newly hatched domestic chicks serve as an important model for experimental studies of neural and behavioral plasticity. Brain-derived neurotrophic factor (BDNF) has been shown to play a critical role in synaptic plasticity, including long-term potentiation, which underlies learning and memory in rodents. Here we show that BDNF mRNA levels increased in the intermediate medial hyperpallium apicale (IMHA), which is the caudal area of the visual Wulst, of imprinted chick brains, and the upregulation of gene expression correlated with the strength of the learned preference to the training object. In addition, activation of tropomyosin-related kinase B (TrkB)/phosphatidylinositol 3-kinase signaling was associated with filial imprinting. However, pharmacological deprivation of TrkB phosphorylation in IMHA did not impair memory formation, suggesting that activation of BDNF/TrkB signaling in IMHA is not involved in memory acquisition in filial imprinting.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Yamaguchi S,Aoki N,Kobayashi D,Kitajima T,Iikubo E,Katagiri S,Matsushima T,Homma KJdoi
10.1097/WNR.0b013e32834d0be7subject
Has Abstractpub_date
2011-12-07 00:00:00pages
929-34issue
17eissn
0959-4965issn
1473-558Xjournal_volume
22pub_type
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