The function and expression of sproutin, a novel neurite outgrowth factor.

abstract：:We investigated the mRNA levels of neuronal, inducible, endothelial nitric oxide synthases (nNOS, iNOS, eNOS) and tumor necrosis factor-alpha (TNF-alpha) in a rat dorsal root ganglion (DRG) after tourniquet application to a hind limb to identify molecules that trigger secondary events after peripheral nerve injury. Si...

journal_title：Neuroreport

authors： Abe S,Mizusawa I,Kanno K,Yabashi A,Suto M,Kuraya M,Honda T,Hiraiwa K

更新日期：2003-12-02 00:00:00

abstract：:Investigating the neural substrates of auditory processing of absolute pitch musicians has relevance for understanding the capabilities of the human brain for plasticity. Electroencephalography was used to examine the N1 of auditory-evoked potentials from absolute pitch musicians, nonabsolute pitch musicians, and nonm...

journal_title：Neuroreport

authors： Wu C,Kirk IJ,Hamm JP,Lim VK

更新日期：2008-05-28 00:00:00

abstract：:This study was carried out based on the assumption that brain-derived neurotrophic factor (BDNF) may counterbalance the action of morphine in the brain. Morphine analgesic tolerance after daily administrations for six days was blocked by intracerebroventricular injection of anti-BDNF IgG on day 5, but not by administr...

journal_title：Neuroreport

authors： Matsushita Y,Ueda H

更新日期：2009-01-07 00:00:00

abstract：:We have reported that corticotropin-releasing factor (CRF) receptor subtypes, CRF1 and CRF2, are involved in stress-induced anorexia. To clarify in which brain regions the CRF receptor is involved in mediating stress-induced anorexia, we examined the effect of microinjecting CRF1-selective or CRF2-selective antagonist...

journal_title：Neuroreport

authors： Ohata H,Shibasaki T

更新日期：2011-07-13 00:00:00

abstract：:We previously reported that the methanol extract of Ashwagandha (roots of Dunal) induced dendrite extension in a human neuroblastoma cell line. In this study, we found that six of the 18 compounds isolated from the methanol extract enhanced neurite outgrowth in human neuroblastoma SH-SY5Y cells. Double immunostaining ...

journal_title：Neuroreport

authors： Kuboyama T,Tohda C,Zhao J,Nakamura N,Hattori M,Komatsu K

更新日期：2002-10-07 00:00:00

abstract：:Sulphated cholecystokinin-8 (CCK-8) given into the neostriatum of the rat by in vivo microdialysis produced a concentration-dependent (1-100 microM) increase in extracellular aspartate (Asp) and dynorphin B (Dyn B), but not in glutamate, GABA or dopamine levels. The increase in Asp levels produced by 10 microM CCK-8 w...

journal_title：Neuroreport

authors： You ZB,Pettersson E,Herrera-Marschitz M,Hökfelt T,Terenius L,Nylander I,Goiny M,Hughes J,O'Connor WT,Ungerstedt U

更新日期：1994-11-21 00:00:00

abstract：:The role of spinal NMDA receptors in mechanical nociceptive processing was assessed in sheep. Intrathecal NMDA (2 nmol-1 micromol) produced a significant reduction in mechanical withdrawal thresholds. This effect was attenuated by pretreatment with the NMDA receptor antagonist MK801 (100 nmol), the cyclooxygenase-2 (C...

journal_title：Neuroreport

authors： Dolan S,Nolan AM

更新日期：1999-02-25 00:00:00

abstract：:Learning and memory are cognitive functions commonly impaired after surgery, especially in elderly patients. Our aim was to evaluate the effect of sevoflurane anaesthesia on episodic-like memory in young and aged wild-type mice and mice with altered nicotinic cholinergic neurotransmission (beta2KO). Mice learned objec...

journal_title：Neuroreport

authors： Wiklund A,Granon S,Faure P,Sundman E,Changeux JP,Eriksson LI

更新日期：2009-10-28 00:00:00

abstract：:Adenosine has an anticonvulsant effect in various models of epilepsy. This effect appears to be mediated through the activation of adenosine A1 receptors (A1Rs). We immunohistochemically investigated the changes of A1Rs expression in kainate-treated and hippocampus-kindled rats as chronic models of epilepsy. In the no...

journal_title：Neuroreport

authors： Ochiishi T,Takita M,Ikemoto M,Nakata H,Suzuki SS

更新日期：1999-11-26 00:00:00

abstract：:Increased oxidative stress in the brain due to chronic ethanol consumption is known to result in a number of neurodegenerative changes. This study was designed to test whether dietary supplementation of grape polyphenols (GP) can offer protection to the neurodegenerative changes resulting from chronic ethanol consumpt...

journal_title：Neuroreport

authors： Sun GY,Xia J,Draczynska-Lusiak B,Simonyi A,Sun AY

更新日期：1999-01-18 00:00:00

abstract：:The aim of this study was to determine the changes of the nociceptive thresholds in response to an acute mechanical stimulus (paw pressure) in magnesium (Mg)-deficient rats, and the involvement of the NMDA receptor in these changes. Changes in vocalization thresholds was determined after 7 days of feeding with a Mg-de...

journal_title：Neuroreport

authors： Dubray C,Alloui A,Bardin L,Rock E,Mazur A,Rayssiguier Y,Eschalier A,Lavarenne J

更新日期：1997-04-14 00:00:00

abstract：:To study the penetration of magnesium ions from blood into brain tissue, magnesium content in serum and hippocampus of normal and of excitotoxically affected rats was estimated after a single subcutaneous injection of magnesium sulphate (600 mg kg-1). In normal rats Mg2+ levels in serum rose from 1 to 6 mM, while that...

journal_title：Neuroreport

authors： Rothe F,Wolf G,Fischer S,Hass P,Keilhoff G,Abicht K

更新日期：1993-02-01 00:00:00

abstract：:Neuropathological and neuroimaging studies indicate a decrease in Purkinje cell (PC) density in the cerebellum of autistic patients and rodent models of autism. Autism is far more prevalent in males than females, and sex-specific properties of PCs have been reported recently. We investigated the differential sensitivi...

journal_title：Neuroreport

authors： Roux S,Bailly Y,Bossu JL

更新日期：2019-01-16 00:00:00

abstract：:Deficiencies of Ca2+ homeostasis are proposed to play an important role in neuronal ageing and/or neurodegeneration. The aim of this study was to investigate, in a defined neuronal population, primary cerebellar granule neuron culture, the time-dependent changes in Ca2+ homeostasis and compare them with data obtained ...

journal_title：Neuroreport

authors： Toescu EC,Verkhratsky A

更新日期：2000-11-27 00:00:00

abstract：:A two-electrode voltage clamp was used to examine the effects of the local anaesthetics (LAs) lidocaine, tetracaine and bupivacaine, and the meta-isomer of lidocaine (LL33), on the gamma-aminobutyric acid (GABA)-gated Cl- channel in the crayfish stretch receptor neurone. The voltage-induced current changes were record...

journal_title：Neuroreport

authors： Nordmark J,Rydqvist B

更新日期：1997-01-20 00:00:00

abstract：:N-methyl-D-aspartate (NMDA) receptors are hetero-oligomeric receptor-channel complexes composed of NR1 and NR2 subunits. Subunit composition determines the properties of NMDA receptor subtypes. However, the molecular mechanisms regulating their subunit composition are unknown. Using reverse transcription (RT)-competit...

journal_title：Neuroreport

authors： Hoffmann H,Hatt H,Gottmann K

更新日期：1997-12-01 00:00:00

abstract：:For many diseases and injuries of the central nervous system, transplantation of neural progenitor cells is being evaluated as a possible treatment option. Although local, intravenous and subarachnoid injections have been reported as administration methods of neural progenitor cells, each of these methods has limitati...

journal_title：Neuroreport

authors： Hamasaki T,Tanaka N,Ishida O,Yanada S,Kamei N,Fujiwara Y,Nishida K,Nakanishi K,Sharman P,Kawamata S,Ochi M

更新日期：2005-10-17 00:00:00

abstract：:The in-vivo extracellular release of acetylcholine (ACh) from the striatum of rats was measured by intracerebral microdialysis. The ACh levels were first estimated under normoxic conditions, after which the rats were exposed to either 10% or 5% oxygen for 1 h. The average ACh content was 2.9 pmol/20 min. During hypoxi...

journal_title：Neuroreport

authors： Chleide E,Ishikawa K

更新日期：1990-11-01 00:00:00

abstract：:Mammalian TIMELESS (TIM) was identified due to its sequence similarity to Drosophila TIM, an essential circadian clock protein in flies. Published literature is inconsistent regarding the rhythmic expression of mammalian Tim, the interaction of the TIM protein with other clock proteins and its role in regulating clock...

journal_title：Neuroreport

authors： Gotter AL

更新日期：2006-08-21 00:00:00

abstract：:Widespread invasiveness, represented by the invasion and migration, is the most important characteristic of glioblastoma multiforme (GBM) and is the main reason for therapeutic failure and recurrence of the tumor. Hypoxia is one of the main microenvironment in determining tumor invasiveness. Therefore, intense efforts...

journal_title：Neuroreport

authors： Huang W,Ding X,Ye H,Wang J,Shao J,Huang T

更新日期：2018-12-12 00:00:00

abstract：:Voltage-gated K+ channels (K(V)) regulate cell electrical properties, proliferation, migration, and death. Rotenone is a mitochondrial inhibitor, influencing activity of many channels that potentially participate in cell death processes, but its effect on K(V) channel in neurons remains unclear. This study used whole-...

journal_title：Neuroreport

authors： Gao XF,Wang W,He C

更新日期：2008-09-17 00:00:00

abstract：:Neurotrophic factors such as brain-derived neurotrophic factor (BDNF) are assumed to provide trophic support via a target-derived, retrograde mechanism of action. However, recent studies suggest that neurotrophic factors can act in an autocrine fashion and perhaps even in an anterograde direction similar to neurotrans...

journal_title：Neuroreport

authors： Smith MA,Zhang LX,Lyons WE,Mamounas LA

更新日期：1997-05-27 00:00:00

abstract：:The cellular distribution of the rat metabotropic glutamate receptor type 4 (mGluR4) was examined in the adult rat cerebral cortex and hippocampus. Antibodies were raised against amino acid residues located in the extracellular amino terminal domain that is common to both the mGluR4a and mGluR4b splice variants, and u...

journal_title：Neuroreport

authors： Phillips T,Makoff A,Brown S,Rees S,Emson P

更新日期：1997-10-20 00:00:00

abstract：:Previous literature shows that feature binding processes elicit fronto-hippocampal areas. The time course of this process, however, remains unknown. This is the first study that investigates feature binding using magnetoencephalography. Synthetic aperture magnetometry analysis was used to localize sources of increased...

journal_title：Neuroreport

authors： Filbey FM,Holroyd T,Carver F,Sunderland T,Cohen RM

更新日期：2005-11-07 00:00:00

abstract：:The Stroop effect refers to an increase in response time observed when the word meaning and the stimulus hue do not match. In an incongruent condition, the word 'green' is presented in the color red, whereas in a congruent condition the word 'red' is presented in the color red. To determine at what level of processing...

journal_title：Neuroreport

authors： Xiao X,Qiu J,Zhang Q

更新日期：2009-05-06 00:00:00

abstract：:Phenylketonuria is the most common, inherited aminoacidopathy associated with brain injury. To date, no study has focused on the neuropathology of the genetic mouse model of phenylketonuria, BTBR-Pah(enu2). We examined dendritic spines and synapses in the CA1 and prefrontal cortex among the wild-type, heterozygous, an...

journal_title：Neuroreport

authors： Liang L,Gu X,Lu L,Li D,Zhang X

更新日期：2011-08-24 00:00:00

abstract：:Brief tetanic stimulation of parallel fibres can evoke a slow excitatory postsynaptic potential (EPSP) in cerebellar Purkinje cells that is mediated by metabotropic glutamate receptors (mGluRs). It is likely that the receptor subtype involved is mGluR1, which couples to the production of diacylglycerol and inositol-1,...

journal_title：Neuroreport

authors： Batchelor AM,Vranesic I,Del Principe F,Garthwaite J,Knöpfel T

更新日期：1996-08-12 00:00:00

abstract：:The pattern of immunoreactivity for amyloid precursor (APP) and B-cell lymphoma protooncogene (Bcl-2) proteins in the rat retina was studied after intravitreal injection of basic fibroblast growth factor (bFGF) or transforming growth factor-beta (TGFbeta). In normal control retinas, intense immunostaining of APP and B...

journal_title：Neuroreport

authors： Chen ST,Jen A,Gentleman SM,Jen LS

更新日期：1999-02-25 00:00:00

abstract：:Short-term exposure of primary cultures of cerebellar granule cells from neonatal rat brain to high concentrations of glutamate results in neuronal degeneration. We found that glutamate, before causing neuronal degeneration, induced a significant increase of Tau protein immunostaining. Time-course experiments revealed...

journal_title：Neuroreport

authors： Pizzi M,Valerio A,Ribola M,Spano PF,Memo M

更新日期：1993-06-01 00:00:00

abstract：:Increased expression and nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) are early, critical events in several forms of apoptosis. In order to investigate the subcellular trafficking of GAPDH in vivo, the localization of a GAPDH-green fluorescent protein (GFP) fusion was studied in PC12, HEK 2...

journal_title：Neuroreport

authors： Shashidharan P,Chalmers-Redman RM,Carlile GW,Rodic V,Gurvich N,Yuen T,Tatton WG,Sealfon SC

更新日期：1999-04-06 00:00:00