Abstract:
:A two-electrode voltage clamp was used to examine the effects of the local anaesthetics (LAs) lidocaine, tetracaine and bupivacaine, and the meta-isomer of lidocaine (LL33), on the gamma-aminobutyric acid (GABA)-gated Cl- channel in the crayfish stretch receptor neurone. The voltage-induced current changes were recorded while exposing the neurone to GABA in saline containing different LAs. All LAs enhanced the voltage-induced Cl- current equivalent to a shift of the conductance vs GABA curve towards lower concentrations. The mechanism of the facilitation of GABA-induced conductance was found to be mainly a block of the GABA uptake in the stretch receptor neurone. Tetracaine, and to a lesser extent LL33, also seem to affect directly the GABA/receptor Cl-/channel complex resulting in an increased conductance of the channel.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Nordmark J,Rydqvist Bdoi
10.1097/00001756-199701200-00018subject
Has Abstractpub_date
1997-01-20 00:00:00pages
465-8issue
2eissn
0959-4965issn
1473-558Xjournal_volume
8pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::We investigated the effects of chemical hypoxia on the central pattern generator controlling swimming in stage 42 Xenopus laevis larvae. We recorded motoneuron activity from ventral roots of immobilized tadpoles and evoked swim episodes by brief electrical stimulation of the tail skin. In the presence of the metabolic...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32833e332d
更新日期:2010-10-06 00:00:00
abstract::Methamphetamine (METH) is a drug of abuse used for its stimulant effects. Its neurotoxicity is very variable, and is increased by a number of factors, including crowded conditions and increased ambient temperature. The effects of such factors are increasingly important, with the widespread use of these stimulants at n...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200110290-00026
更新日期:2001-10-29 00:00:00
abstract::S100B is a calcium binding protein from astrocytes that regulates protein phosphorylation by binding to substrates and protein kinases. S100B might also regulate protein phosphatases and this was investigated for protein phosphatase 2B (calcineurin). The results indicate that S100B (5-10 microM) increased the activity...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200402090-00021
更新日期:2004-02-09 00:00:00
abstract::Sex differences in event-related potentials were examined in 23 women and 24 men during a mental rotation task. We found an early (130-400 ms) and a late (400-700 ms) ERP mental rotation effect. The late rotation effect, which is thought to indicate the onset of the cognitive process of mental rotation, emerged about ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282f519b3
更新日期:2008-02-12 00:00:00
abstract::Muller glial cells of the sensory retina mediate K+ and water fluxes that are facilitated by aquaporin-4 (AQP4) water channels and by Kir4.1-K+ channels. However, it is not known which subtypes of aquaporins are expressed in the mammalian retina. Using RT-PCR, we found that both human and rat retinas express mRNA for ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200501190-00013
更新日期:2005-01-19 00:00:00
abstract::Stop-consonant discrimination was investigated in normal-hearing listeners and cochlear-implanted patients (CIP) by recording auditory evoked potentials (AEPs) to /b epsilon/ and /p epsilon/ syllables. This study demonstrates that: (i) AEPs show time-locked components that mimic the temporal structure of the stimuli, ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200403220-00006
更新日期:2004-03-22 00:00:00
abstract::Oculopharyngeal muscular dystrophy (OPMD) is an autosomal dominant muscular dystrophy characterized by late onset ptosis, proximal muscle weakness and swallowing difficulties. This disease has been recently linked to chromosome 14q11.2-q13 in French-Canadian pedigrees. We studied three unrelated American families with...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199804200-00002
更新日期:1998-04-20 00:00:00
abstract::Epidemiological data show correlations between hypercholesterolemia and Alzheimer's disease (AD). We test the hypothesis that hypercholesterolemia modulates Abeta deposition in mice overexpressing the human APP695 Swedish mutation (K670N and M671L) (TgAPPsw). Feeding mice a high fat/high cholesterol (HFHC) diet for 7-...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200203250-00019
更新日期:2002-03-25 00:00:00
abstract::Dopamine D2 receptor (D2R) signalling is implicated in limbic seizure propagation and seizure-induced neurodegeneration. D2R-/- mice display increased susceptibility to kainic acid (KA) seizures and seizure-induced apoptosis of hippocampal neurons. Here we further investigated the molecular pathways of KA-induced apop...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32833d5891
更新日期:2010-08-23 00:00:00
abstract::The benzodiazepine, lorazepam enhances the efficiency of local, inhibitory GABA(A) synapses in the cortex, which stabilize postsynaptic, excitatory activity by synchronizing their own discharges at around 40 Hz. Treatment with lorazepam has also been shown to adversely influence detection performance in perceptual tas...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00001756-200010200-00027
更新日期:2000-10-20 00:00:00
abstract::We investigated the protective effects of edaravone, a free radical scavenger, against ischemic damage of inner hair cells (IHCs) in gerbils. Cochlear ischemia was induced in the animals by occluding the vertebral arteries bilaterally for 15 min. Edaravone (1 mg/kg, i.v.) or saline was administered 1 h after ischemia....
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200310060-00025
更新日期:2003-10-06 00:00:00
abstract::Magnetic brain responses were recorded to clarify the cortical representation of vowel processing in Japanese. We investigated the peak latencies and equivalent current dipoles of the auditory N1m responses to the Japanese vowels [a], [i], [o], and [u]. In intraindividual analyses for a single participant, well-replic...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000230503.47973.b7
更新日期:2006-07-31 00:00:00
abstract::When we perform a visually guided reaching action, the brain coordinates our hand and eye movements. Eye-hand coordination has been examined widely, but it remains unclear whether the hand and eye motor systems are coordinated during on-line visuomotor adjustments induced by a target jump during a reaching movement. A...
journal_title:Neuroreport
pub_type: 杂志文章,随机对照试验
doi:10.1097/WNR.0000000000000111
更新日期:2014-05-07 00:00:00
abstract::Anterior cingulate integrity may be required for antidepressant response. To assess anterior cingulate processes related to treatment response, we studied error-related negativity and error positivity produced during an emotional go/no-go challenge, a task activating the rostral anterior cingulate. Twelve elderly pati...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328013ceda
更新日期:2007-02-12 00:00:00
abstract::The hypothalamus is a limbic structure involved in the emergence and persistence of major depressive disorder symptoms. Previous studies have indicated that major depressive disorder patients exhibited dysregulation between the hypothalamus and cerebral regions. However, it is still unclear about the exact hypothalami...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001335
更新日期:2019-11-06 00:00:00
abstract::Mutations in the presenilin genes are involved in the aetiology of the majority of familial early-onset Alzheimer disease (AD) cases. Presenilin 1 (PS1) is proteolytically processed in vivo, resulting in the accumulation of N-terminal approximately 27-28 kDa and C-terminal approximately 18 kDa derivatives. To examine ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199705060-00030
更新日期:1997-05-06 00:00:00
abstract::Ciliary neurotrophic factor (CNTF) attracts considerable attention because it supports survival and differentiation of various types of neurons and glial cells in vitro. Although CNTF functions as a moderate neurotrophic factor in mature motor neurons, its role in embryonic development remains unknown. Here, we found ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200204160-00039
更新日期:2002-04-16 00:00:00
abstract::Olfactory cues can elicit intense emotional responses. This study used fMRI in male common marmoset monkeys to identify brain areas associated with sexual arousal in response to odors of ovulating female monkeys. Under light anesthesia, monkeys were secured in a specially designed restrainer and positioned in a 9.4 T ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200107200-00037
更新日期:2001-07-20 00:00:00
abstract::A double-stranded DNA end-binding factor with high levels of expression in brain and testis of adult mice was identified as the Ku protein, earlier described as an autoantigen in connective tissue diseases and found to be essential for recombination of the immunoglobulin genes and DNA repair. High Ku levels were found...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199806220-00044
更新日期:1998-06-22 00:00:00
abstract::Our research objective was to characterize the biochemical effect of streptomycin during postnatal rat cerebral cortex development using a sensitive method that preserves the in situ topological relationship. We found a decrease in the mannosylation of asparagine-linked oligosaccharides without affecting polypeptide s...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200011090-00033
更新日期:2000-11-09 00:00:00
abstract::The present study was based on earlier findings that the observation of a coherently moving long bar induced gamma-band activity in humans. The power in the EEG-gamma-band was reduced during the presentation of two incoherently moving short bars. The present study demonstrates the replicability of this cortical activi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199707280-00031
更新日期:1997-07-28 00:00:00
abstract::Factors controlling proliferation and differentiation are crucial in advancement of neural cell-based experimental neurodegenerative therapies. In this regard, nicotinamide has been shown to determine the fate of neural cells, enhance neuralization, and influence DNA repair and apoptosis. This study investigated wheth...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000071
更新日期:2013-12-18 00:00:00
abstract::Basic FGF mRNA induction by bFGF was investigated in cell cultures from rat brain, i.e. postnatal day 2 cortex and embryonic day 18 hippocampus. In situ hybridization shows that after bFGF treatment (10(-10) M) for 14 h neurones and glial cells show a remarkable increase in bFGF mRNA production. Incubation of astrocyt...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199212000-00011
更新日期:1992-12-01 00:00:00
abstract::Human brain homogenate proteins were analyzed for binding and processing activity in relation to brain beta-amyloid precursor protein (APP). The homogenate was purified by arginine-Sepharose 4B affinity chromatography, which traps proteins with affinity to certain groups of arginine residue, such as serine proteases a...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199710200-00021
更新日期:1997-10-20 00:00:00
abstract::Using cRNA in situ hybridization, the regional distribution of mRNA encoding the human Y1 receptor was investigated in the normal human brain and compared with the autoradiographic distribution of putative Y1/[125I][Leu31,Pro34]PYY binding sites. Surprisingly, relatively high levels of Y1 receptor mRNA, distributed in...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199604100-00020
更新日期:1996-04-10 00:00:00
abstract::Deficits in auditory sensory memory at the electrophysiological level as indexed by mismatch negativity and those in auditory verbal memory at the neuropsychological level have been independently demonstrated in previous studies of schizophrenia. We predicted a specific association between these indices in schizophren...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000221828.10846.ba
更新日期:2006-07-17 00:00:00
abstract::We have reported that corticotropin-releasing factor (CRF) receptor subtypes, CRF1 and CRF2, are involved in stress-induced anorexia. To clarify in which brain regions the CRF receptor is involved in mediating stress-induced anorexia, we examined the effect of microinjecting CRF1-selective or CRF2-selective antagonist...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283487467
更新日期:2011-07-13 00:00:00
abstract::The mechanism by which IL-1 beta exerts its actions in the brain during systemic inflammation is not fully understood, as neither IL-1 receptor gene expression nor IL-1 binding have been identified in significant levels in key areas that respond to IL-1 beta. Having hypothesized that perivascular nitric oxide (NO) mig...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199611040-00008
更新日期:1996-11-04 00:00:00
abstract::DNA methylation is important for controlling gene expression and is catalyzed by DNA methyltransferase (Dnmt1) an enzyme abundant in brain. We recently demonstrated that mice expressing reduced levels of Dnmt1 are protected from cerebral ischemia. Here, we used the cre/loxP system to produce conditional mutants that l...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200112040-00032
更新日期:2001-12-04 00:00:00
abstract::There is disagreement in the literature as to whether smooth pursuit latency is reduced when a temporal gap is introduced between the extinction of a central fixation target and the illumination of an eccentric moving target. This study confirms that in human subjects smooth pursuit latency is reduced by gaps and that...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199803300-00008
更新日期:1998-03-30 00:00:00