Abstract:
:Basic FGF mRNA induction by bFGF was investigated in cell cultures from rat brain, i.e. postnatal day 2 cortex and embryonic day 18 hippocampus. In situ hybridization shows that after bFGF treatment (10(-10) M) for 14 h neurones and glial cells show a remarkable increase in bFGF mRNA production. Incubation of astrocytes with antisense bFGF phosphorothioate oligodeoxynucleotides (bFGF-PTOs) resulted in an inhibition of both bFGF induced and serum induced proliferation. The results indicate that bFGF is capable of inducing its own mRNA production. This induction, i.e. new synthesis of bFGF mRNA, seems to be essential for the mitogenic effect of both bFGF and serum components.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Flott-Rahmel B,Gerdes W,Pechan PA,Brysch W,Schlingensiepen KH,Seifert Wdoi
10.1097/00001756-199212000-00011subject
Has Abstractpub_date
1992-12-01 00:00:00pages
1077-80issue
12eissn
0959-4965issn
1473-558Xjournal_volume
3pub_type
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