Involvement of CRF2 receptor in the brain regions in restraint-induced anorexia.

Abstract:

:We have reported that corticotropin-releasing factor (CRF) receptor subtypes, CRF1 and CRF2, are involved in stress-induced anorexia. To clarify in which brain regions the CRF receptor is involved in mediating stress-induced anorexia, we examined the effect of microinjecting CRF1-selective or CRF2-selective antagonist into the lateral septum or the bed nucleus of the stria terminalis (BNST), which are implicated in regulating stress response. The results demonstrated that injecting antisauvagine-30 into the lateral septum or the BNST significantly attenuated restraint-induced anorexia, whereas injecting antalarmin into these regions did not affect anorexia. These results suggest that the CRF2 receptor in the lateral septum and the BNST is involved in the stress-induced inhibitory mechanism of feeding behavior.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Ohata H,Shibasaki T

doi

10.1097/WNR.0b013e3283487467

subject

Has Abstract

pub_date

2011-07-13 00:00:00

pages

494-8

issue

10

eissn

0959-4965

issn

1473-558X

journal_volume

22

pub_type

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