Membrane-associated prostaglandin E synthase-1 is required for neuropathic pain.

Abstract:

:It is widely accepted that prostaglandin (PG) E2 is the principal pro-inflammatory prostanoid and plays an important role in inflammatory pain. However whether PGE2 is involved in neuropathic pain remains unknown. PGE2 is produced from arachidonic acid via PGH2 by at least three PGE synthases (PGES), cytosolic PGES (cPGES), and membrane-associated PGES (mPGES)-1 and -2. In the present study, to clarify the involvement of PGE2 and identify PGES mediating neuropathic pain, we applied a neuropathic pain model prepared by L5 spinal nerve transection to mPGES-1 knockout (mPGES-1-/-) mice. Whereas they retained normal nociceptive responses, mPGES-1-/- mice did not exhibit mechanical allodynia and thermal hyperalgesia over a week. These results demonstrate that PGE2 produced by mPGES-1 is involved in neuropathic pain.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Mabuchi T,Kojima H,Abe T,Takagi K,Sakurai M,Ohmiya Y,Uematsu S,Akira S,Watanabe K,Ito S

doi

10.1097/01.wnr.0000129372.89000.31

subject

Has Abstract

pub_date

2004-06-28 00:00:00

pages

1395-8

issue

9

eissn

0959-4965

issn

1473-558X

pii

00001756-200406280-00005

journal_volume

15

pub_type

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