Sexual receptivity is reduced in the female mu-opioid receptor knockout mouse.

Abstract:

:Activation of mu-opioid receptors is critical to steroid regulation of female sexual behavior, lordosis, in rodents. Estrogen treatment activates mu-opioid receptors in the medial preoptic area inhibiting lordosis, but ultimately appears important for progesterone facilitation of lordosis. We investigated the role of mu-opioid receptors in the expression of sexual receptivity in mice lacking mu-opioid receptors. Although estrogen and progesterone facilitated lordosis in mu-opioid receptor knockout mice, they exhibited deficits in lordosis quotient and score compared with wild-type females, indicating reduced sexual receptivity. In contrast, wild-type and mu-opioid receptor knockout female mice did not differ in either active or passive avoidance of the male. These data are most consistent with the hypothesis that mu-opioid receptor activation is necessary for estrogen and progesterone to maximally facilitate lordosis.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Sinchak K,Shahedi K,Dewing P,Micevych P

doi

10.1097/01.wnr.0000181585.49130.93

subject

Has Abstract

pub_date

2005-10-17 00:00:00

pages

1697-700

issue

15

eissn

0959-4965

issn

1473-558X

pii

00001756-200510170-00017

journal_volume

16

pub_type

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