Abstract:
:Activation of mu-opioid receptors is critical to steroid regulation of female sexual behavior, lordosis, in rodents. Estrogen treatment activates mu-opioid receptors in the medial preoptic area inhibiting lordosis, but ultimately appears important for progesterone facilitation of lordosis. We investigated the role of mu-opioid receptors in the expression of sexual receptivity in mice lacking mu-opioid receptors. Although estrogen and progesterone facilitated lordosis in mu-opioid receptor knockout mice, they exhibited deficits in lordosis quotient and score compared with wild-type females, indicating reduced sexual receptivity. In contrast, wild-type and mu-opioid receptor knockout female mice did not differ in either active or passive avoidance of the male. These data are most consistent with the hypothesis that mu-opioid receptor activation is necessary for estrogen and progesterone to maximally facilitate lordosis.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Sinchak K,Shahedi K,Dewing P,Micevych Pdoi
10.1097/01.wnr.0000181585.49130.93subject
Has Abstractpub_date
2005-10-17 00:00:00pages
1697-700issue
15eissn
0959-4965issn
1473-558Xpii
00001756-200510170-00017journal_volume
16pub_type
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