Abstract:
:The synthesis and release of 3H-acetylcholine was measured in hippocampal slices of adult rat brain following acute in vitro exposure to ethanolamine. Evoked release of 3H-acetylcholine was elevated by 60-70% but 3H-acetylcholine synthesis was unaffected. Other amino alcohols were also found to significantly increase evoked 3H-acetylcholine release. The effect may be stereochemically mediated since only one of four possible propanolamine configurations, R-alaninol, was active. The most potent compound tested was R-prolinol which showed an EC50 nearly 10-fold lower than that of either R-alaninol or ethanolamine; S-prolinol was inactive. Slices taken from adult rats which had been fed active compounds for two weeks also exhibited enhancements in evoked 3H-acetylcholine release. These results indicate that amino alcohols modulate acetylcholine release in the rat hippocampus.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Bostwick JR,Abbe R,Sun J,Appel SHdoi
10.1097/00001756-199205000-00012subject
Has Abstractpub_date
1992-05-01 00:00:00pages
425-8issue
5eissn
0959-4965issn
1473-558Xjournal_volume
3pub_type
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