MK-801 decreases striatal and cortical GAD65 mRNA levels.


:Levels of mRNAs encoding for the two isoforms of glutamate decarboxylase, GAD67 and GAD65, were quantified in the rat striatum and cerebral cortex following single injections of the non-competitive NMDA receptor antagonist MK-801. Acute MK-801 induced a dose-dependent decrease in GAD65 mRNA levels in ventral sectors of the dorsal striatum. No statistically significant changes in GAD67 mRNA levels were measured in the same conditions. In the frontal and cingulate cortex, GAD65 but not GAD67 mRNA levels were significantly decreased after a single high dose of MK-801 (0.1 mg kg-1). These results suggest that NMDA receptors are involved in the transcriptional regulation of the GABA synthesizing enzyme, GAD65.






Laprade N,Soghomonian JJ




Has Abstract


1995-10-02 00:00:00












  • Neuroinflammation in the pathogenesis of amyotrophic lateral sclerosis.

    abstract::Amyotrophic lateral sclerosis is a devastating motor neuron disorder. Traditionally regarded as a 'neuron only' disease, recent evidence suggested that other cells contribute critically to the pathogenesis. This review provides a short synopsis of the role neuroinflammation and microglial cells play in the disease and...


    pub_type: 杂志文章,评审


    authors: Weydt P,Möller T

    更新日期:2005-04-25 00:00:00

  • Impaired discrimination learning in interneuronal NMDAR-GluN2B mutant mice.

    abstract::Previous studies have established a role for N-methyl-D-aspartate receptor (NMDAR) containing the GluN2B subunit in efficient learning behavior on a variety of tasks. Recent findings have suggested that NMDAR on GABAergic interneurons may underlie the modulation of striatal function necessary to balance efficient acti...


    pub_type: 杂志文章


    authors: Brigman JL,Daut RA,Saksida L,Bussey TJ,Nakazawa K,Holmes A

    更新日期:2015-06-17 00:00:00

  • Altered whole-brain gray matter volume in primary angle closure glaucoma patients: a voxel-based morphometry study.

    abstract::The study aimed to compare the whole-brain gray matter volume (GMV) and white matter volume (WMV) difference between primary angle closure glaucoma (PACG) patients and health controls (HCs) using a voxel-based morphometry method. A total of 27 patients with PACG (17 males and 10 females) and 27 HCs (17 males and 10 fe...


    pub_type: 杂志文章


    authors: Jiang F,Zeng FF,Yu C,Ye YQ,Zeng XJ

    更新日期:2018-11-07 00:00:00

  • Effects of phenytoin on the persistent Na+ current of mammalian CNS neurones.

    abstract::Whole-cell recordings in voltage-clamp mode were performed on acutely isolated neurones from rat neocortex and neostriatum to examine the effects of the anticonvulsant phenytoin on a non-inactivating (persistent) Na+ current (INaP). INaP was chosen because it enhances neuronal excitability near firing threshold, which...


    pub_type: 杂志文章


    authors: Chao TI,Alzheimer C

    更新日期:1995-09-11 00:00:00

  • Sex differences in the latency of the late event-related potential mental rotation effect.

    abstract::Sex differences in event-related potentials were examined in 23 women and 24 men during a mental rotation task. We found an early (130-400 ms) and a late (400-700 ms) ERP mental rotation effect. The late rotation effect, which is thought to indicate the onset of the cognitive process of mental rotation, emerged about ...


    pub_type: 杂志文章


    authors: Gootjes L,Bruggeling EC,Magnée T,Van Strien JW

    更新日期:2008-02-12 00:00:00

  • Audiogenic seizure susceptibility in thyroid hormone receptor beta-deficient mice.

    abstract::As early-onset hypothyroidism produces audiogenic seizure susceptibility (AGS) in rodents, the role of TR alpha 1 and TR beta thyroid hormone receptors in AGS was investigated. AGS occurs in mice lacking specifically TR beta (Thrb(tm1/tm1)) and is marked by early onset and persistence, thereby differing from mouse str...


    pub_type: 杂志文章


    authors: Ng L,Pedraza PE,Faris JS,Vennström B,Curran T,Morreale de Escobar G,Forrest D

    更新日期:2001-08-08 00:00:00

  • The avian inferior olive derives from the alar neuroepithelium of the rhombomeres 7 and 8: an analysis by using chick-quail chimeric embryos.

    abstract::Homotopic and isochronic transplantation of the alar plate of the rhombomeres 7 and 8 was performed between chick and quail embryos at the stage of 10-14 somites. Analysis of the graft derivatives in 12-day-old chimeric embryos by means of the quail nucleolar marker showed that the ipsilateral inferior olive is formed...


    pub_type: 杂志文章


    authors: Ambrosiani J,Armengol JA,Martinez S,Puelles L

    更新日期:1996-05-17 00:00:00

  • Proteolipid DM-20 predominates over PLP in peripheral nervous system.

    abstract::The major central nervous system (CNS) myelin proteolipid (PLP) is also expressed in the peripheral nervous system (PNS). This paper gives evidence that DM-20, an isoform of PLP, also occurs in rat sciatic nerves, where, in contrast to what is seen in CNS myelin, it predominates over PLP. This conclusion was reached o...


    pub_type: 杂志文章


    authors: Pham-Dinh D,Birling MC,Roussel G,Dautigny A,Nussbaum JL

    更新日期:1991-02-01 00:00:00

  • Change of vanilloid receptor 1 expression in dorsal root ganglion and spinal dorsal horn during inflammatory nociception induced by complete Freund's adjuvant in rats.

    abstract::The present study aimed to systematically observe the change of vanilloid receptor 1 (VR1) during inflammatory nociception induced by intraplantar injection of complete Freund's adjuvant (CFA) into the left hind paw in rats. Hot plate latency (HPL) was used to evaluate resulting thermal hyperalgesia and immunohistoche...


    pub_type: 杂志文章


    authors: Luo H,Cheng J,Han JS,Wan Y

    更新日期:2004-03-22 00:00:00

  • To bet or not to bet? The coding of bets modulates brain potentials in outcome evaluations.

    abstract::Decisions made on the basis of risk often require rapid evaluation of feedback before follow-up actions and feedback-related negativity in brain potential is sensitive to the poor outcome. The current study investigated the effects of feedback from one's own decision (Experiment 1) and feedback from observing others' ...


    pub_type: 杂志文章


    authors: Liu Y,Dou K,Wang Y,Li J

    更新日期:2015-11-11 00:00:00

  • Event-related brain potentials elicited by a number discrimination task.

    abstract::To study the number cognition process, we recorded event-related potentials (ERPs) in 14 subjects when they were indicating whether a number pair was the same or not. The two numbers given in sequence were either the same (condition 1) or different (condition 2). After 270 ms following the onset of the second stimulus...


    pub_type: 临床试验,杂志文章


    authors: Kong J,Wang Y,Zhang W,Wang H,Wei H,Shang H,Yang X,Zhuang D

    更新日期:2000-04-27 00:00:00

  • Substantial telomere shortening in the substantia nigra of telomerase-deficient mice does not increase susceptibility to MPTP-induced dopamine depletion.

    abstract::The most important risk factor for developing Parkinson's disease (PD) is age. Aging is ascribed to different mechanisms, including telomere shortening. Telomeres consist of repetitive DNA sequences and stabilize chromosome integrity. Currently, however, the data reported on telomere shortening in PD patients are inco...


    pub_type: 杂志文章


    authors: Oeckl P,Scheffold A,Lechel A,Rudolph KL,Ferger B

    更新日期:2014-03-26 00:00:00

  • Left-hemisphere dominance for processing of vowels: a whole-scalp neuromagnetic study.

    abstract::Brain activation of 11 healthy right-handed subjects was studied with magnetoencephalography to estimate individual hemispheric dominance for speech sounds. The auditory stimuli comprised binaurally presented Finnish vowels, tones, and piano notes in groups of two or four stimuli. The subjects were required to detect ...


    pub_type: 临床试验,杂志文章


    authors: Gootjes L,Raij T,Salmelin R,Hari R

    更新日期:1999-09-29 00:00:00

  • Two classes of potassium currents in Xenopus muscle cells in young cultures.

    abstract::The aim of the present study was to determine if both inactivating and non-inactivating potassium currents occur in skeletal muscle cells at early times in culture. Whole cell current was recorded from embryonic muscle cells within 4-10 h of plating. We found that in the cells which had an outward current, half had a ...


    pub_type: 杂志文章


    authors: Moody-Corbett F,Gilbert R

    更新日期:1992-04-01 00:00:00

  • Sleeping brain, learning brain. The role of sleep for memory systems.

    abstract::The hypothesis that sleep participates in the consolidation of recent memory traces has been investigated using four main paradigms: (1) effects of post-training sleep deprivation on memory consolidation, (2) effects of learning on post-training sleep, (3) effects of within sleep stimulation on the sleep pattern and o...


    pub_type: 杂志文章,评审


    authors: Peigneux P,Laureys S,Delbeuck X,Maquet P

    更新日期:2001-12-21 00:00:00

  • Quadrupedal locomotor movements in monkeys (M. Fuscata) on a treadmill: kinematic analyses.

    abstract::Three adult Japanese monkeys (M. fuscata: body weights 4.5-8.5 kg) were trained to walk quadrupedally on a surface of a moving treadmill (walking length and width: 150 cm and 60 cm, treadmill speed: 0.4-1.7 m s-1. At any different constant treadmill velocity, the monkeys exhibited a diagonal pattern of locomotor movem...


    pub_type: 杂志文章


    authors: Mori S,Miyashita E,Nakajima K,Asanome M

    更新日期:1996-10-02 00:00:00

  • MPTP induces alpha-synuclein aggregation in the substantia nigra of baboons.

    abstract::1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity reproduces many of the features of Parkinson's disease (PD). alpha-Synuclein has been identified as a prominent component of the Lewy body (LB), the pathological hallmark of PD. MPTP-treated primates have been reported to develop intraneuronal inclusion...


    pub_type: 杂志文章


    authors: Kowall NW,Hantraye P,Brouillet E,Beal MF,McKee AC,Ferrante RJ

    更新日期:2000-01-17 00:00:00

  • Immunolocalization of two cytochrome P450 isozymes in rat nasal chemosensory tissue.

    abstract::The NMa and NMb isoforms of cytochrome P450 enzymes are expressed in three nasal chemosensory organs: the olfactory, septal and vomeronasal mucosae. The NMa isoform is widely distributed throughout the nasal mucosa whereas the NMb isoform is present primarily in the chemosensory mucosae. The localization of cytochrome...


    pub_type: 杂志文章


    authors: Chen Y,Getchell ML,Ding X,Getchell TV

    更新日期:1992-09-01 00:00:00

  • BDNF, but not NT-3, promotes long-term survival of axotomized adult rat corticospinal neurons in vivo.

    abstract::Axotomy-induced death of corticospinal neurons (CSN) is prevented by intracotrical infusions of BDNF or NT-3 within the first week after axotomy. The present study examined whether this represents merely a delay of CSN death or whether BDNF and NT-3 can promote long-term survival of these neurons in vivo. The neurotro...


    pub_type: 杂志文章


    authors: Hammond EN,Tetzlaff W,Mestres P,Giehl KM

    更新日期:1999-08-20 00:00:00

  • Activation of inwardly rectifying K+ channels by GABA-B receptors expressed in Xenopus oocytes.

    abstract::In Xenopus oocytes coinjected with poly(A)+ RNA derived from the rat cerebellum and cRNAs for the cloned G protein-gated inwardly rectifying K+ channel (GIRK), GIRK1 and GIRK2, the GABA-B agonist baclofen elicited inwardly rectifying K+ currents. The inward K+ currents elicited by baclofen were inhibited by the select...


    pub_type: 杂志文章


    authors: Uezono Y,Akihara M,Kaibara M,Kawano C,Shibuya I,Ueda Y,Yanagihara N,Toyohira Y,Yamashita H,Taniyama K,Izumi F

    更新日期:1998-03-09 00:00:00

  • A derivative of a rigid glutamate analog protects the retina from excitotoxicity.

    abstract::In the retina, the activation of metabotropic glutamate receptors (mGluRs) reduces the toxic effect of N-methyl-D-aspartate (NMDA). We have induced NMDA-mediated excitotoxicity in the adult rat retina by a single intraocular injection of NMDA. The damage that resulted was estimated by assessing the NMDA-induced loss o...


    pub_type: 杂志文章


    authors: Siliprandi R,Lipartiti M,Fadda E,Arban R,Kozikowski AP,Manev H

    更新日期:1994-06-02 00:00:00

  • Impaired P600 in neuroleptic naive patients with first-episode schizophrenia.

    abstract::Deficits of working memory (WM) are recognized as an important pathological feature in schizophrenia. Since the P600 component of event related potentials has been hypothesized that represents aspects of second-pass parsing processes of information processing, and is related to WM, the present study focuses on P600 el...


    pub_type: 杂志文章


    authors: Papageorgiou C,Kontaxakis VP,Havaki-Kontaxaki BJ,Stamouli S,Vasios C,Asvestas P,Matsopoulos GK,Kontopantelis E,Rabavilas A,Uzunoglu N,Christodoulou GN

    更新日期:2001-09-17 00:00:00

  • Effects of body weight-supported treadmill training at different speeds on the motor function and depressive behaviors after spinal cord injury in rats.

    abstract::Spinal cord injury (SCI) causes motor dysfunction and depression, which hinders the recovery of motor function. Body weight-supported treadmill training (BWSTT) should be considered an effective method for functional rehabilitation after SCI, as it is an efficacious intervention in healthcare with no side effects. Bec...


    pub_type: 杂志文章


    authors: Liu CH,Zhao BL,Li WT,Zhou XH,Jin Z,An LB

    更新日期:2020-12-16 00:00:00

  • Perceptual and response bias in visuospatial neglect due to frontal and parietal repetitive transcranial magnetic stimulation in normal subjects.

    abstract::Recently some authors have challenged the conventional association of directional motor neglect with damage of frontal structures, showing that pure sensory perceptual neglect (classically associated with parietal lesion) can follow damage of right frontal cortex. The aim of the present study was to assess the type of...


    pub_type: 杂志文章


    authors: Brighina F,Bisiach E,Piazza A,Oliveri M,La Bua V,Daniele O,Fierro B

    更新日期:2002-12-20 00:00:00

  • Musashi-1 expression in postnatal mouse olfactory epithelium.

    abstract::We investigated the age-related change in the distribution of a molecular marker for neural stem and precursor cells, Musashi-1, in the olfactory epithelium of mice from 1 day up to 16 months of age using immunohistochemistry. We also compared the distribution pattern of Musashi-1 with that of growth-associated protei...


    pub_type: 杂志文章


    authors: Watanabe K,Kondo K,Takeuchi N,Okano H,Yamasoba T

    更新日期:2007-05-07 00:00:00

  • Immunohistochemical study of the hnRNP A2 and B1 in the rat forebrain.

    abstract::Immunohistochemical techniques were employed to examine the distribution of RNA-binding proteins A2 and B1 in the rat forebrain. Intense A2 and B1 immunolabeling were observed in the nucleoplasm of the neurons in the cerebral cortices, hippocampal formation, olfactory regions, caudate-putamen as well as the supraoptic...


    pub_type: 杂志文章


    authors: Mizukami K,Kamma H,Ishikawa M,Dreyfuss G

    更新日期:2000-09-28 00:00:00

  • Mesolimbic gender differences in peptide CART mRNA expression: effects of cocaine.

    abstract::The putative neurotransmitter peptide CART has been suggested to be involved in the actions of psychostimulants. We analyzed the CART mRNA expression in mesolimbic brain areas of male and ovariectomized 17beta-estradiol- (30 microg) and vehicle-treated female rats. A gender difference was noted in the accumbens shell ...


    pub_type: 杂志文章


    authors: Fagergren P,Hurd YL

    更新日期:1999-11-08 00:00:00

  • Acute exercise increases oxygenated and deoxygenated hemoglobin in the prefrontal cortex.

    abstract::Both acute and chronic exercise is consistently associated with a number of benefits to physical and mental health, including cardiovascular function, body weight, mood, and cognition. Near-infrared spectroscopy is an ideal method to measure changes in oxygenated and deoxygenated hemoglobin (O2Hb and dHb) levels in th...


    pub_type: 杂志文章


    authors: Giles GE,Brunyé TT,Eddy MD,Mahoney CR,Gagnon SA,Taylor HA,Kanarek RB

    更新日期:2014-11-12 00:00:00

  • Denervation impairs cutaneous microvascular function and blister healing in the rat hindlimb.

    abstract::Skin sensory nerve nocifensor functions were investigated non-invasively in rats by measuring neurogenic inflammation and blister healing-rate after unilateral hindlimb denervation. Axon reflexes were evoked by transdermal iontophoresis of acetylcholine (ACh) or noxious electrical stimulation (TNS). Sodium nitroprussi...


    pub_type: 杂志文章


    authors: Carr RW,Delaney CA,Westerman RA,Roberts RG

    更新日期:1993-05-01 00:00:00

  • Atypical temporal lobe language representation: MEG and intraoperative stimulation mapping correlation.

    abstract::Functional brain imaging techniques hold many promises as the methods of choice for identifying areas involved in the execution of language functions. The success of any of these techniques in fulfilling this goal depends upon their ability to produce maps of activated areas that overlap with those obtained through st...


    pub_type: 杂志文章


    authors: Simos PG,Breier JI,Maggio WW,Gormley WB,Zouridakis G,Willmore LJ,Wheless JW,Constantinou JE,Papanicolaou AC

    更新日期:1999-01-18 00:00:00