Abstract:
:The time course of heat-shock protein 70 (HSP70) transcriptional induction was compared with neuronal- and non-neuronal-specific mRNAs following intrastriatal quinolinate (QA) injection. Within one hour of QA exposure, immediate-early gene (IEG; c-fos) activation preceded slight increases in glutamic acid decaroxylase (GAD) mRNA levels. However, glial fibrillary acid protein (GFAP) and HSP70 mRNA levels remained constant. After one hour, HSP70 mRNA levels surged 6 fold during a delayed transcriptional phase that was induced between 4-12 hours. This phase was characterized by massive increases in c-fos and GFAP mRNAs while GAD transcripts fell drastically suggestive of neuronal death. Therefore HSP70 genes may play an important role in glial/immune activation following rapid excitotoxic damage by direct injections of quinolinate.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Walker PD,Carlock LRdoi
10.1097/00001756-199306000-00024subject
Has Abstractpub_date
1993-06-01 00:00:00pages
699-702issue
6eissn
0959-4965issn
1473-558Xjournal_volume
4pub_type
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