Abstract:
:We examined effects of trial averaging upon spatial extent, spatial topography, and temporal properties of fMRI activation. Two subjects participated in an event-related visual stimulation design. There was an exponential relation between number of trials and spatial extent, such that additional trials identified, on average, a constant proportion of the remaining voxels. At values typical of fMRI experimentation (e.g. 50 trials) only about 50% of eventually active voxels were significant; asymptotic values were approached by 150 trials. The variability of the estimated hemodynamic response decreased with signal averaging, becoming stable across samples of > or = 25 trials. Therefore, group or condition differences may result from differences in voxelwise noise exacerbated by averaging small numbers of trials.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Huettel SA,McCarthy Gdoi
10.1097/00001756-200108080-00025subject
Has Abstractpub_date
2001-08-08 00:00:00pages
2411-6issue
11eissn
0959-4965issn
1473-558Xjournal_volume
12pub_type
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