The effects of single-trial averaging upon the spatial extent of fMRI activation.

Abstract:

:We examined effects of trial averaging upon spatial extent, spatial topography, and temporal properties of fMRI activation. Two subjects participated in an event-related visual stimulation design. There was an exponential relation between number of trials and spatial extent, such that additional trials identified, on average, a constant proportion of the remaining voxels. At values typical of fMRI experimentation (e.g. 50 trials) only about 50% of eventually active voxels were significant; asymptotic values were approached by 150 trials. The variability of the estimated hemodynamic response decreased with signal averaging, becoming stable across samples of > or = 25 trials. Therefore, group or condition differences may result from differences in voxelwise noise exacerbated by averaging small numbers of trials.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Huettel SA,McCarthy G

doi

10.1097/00001756-200108080-00025

subject

Has Abstract

pub_date

2001-08-08 00:00:00

pages

2411-6

issue

11

eissn

0959-4965

issn

1473-558X

journal_volume

12

pub_type

杂志文章
  • The AMPA antagonist, NBQX, protects against ischemia-induced loss of cerebellar Purkinje cells.

    abstract::We examined the effect of an AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole) antagonist, 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo (F) quinoxaline (NBQX), on rat cerebellar Purkinje cell loss and hippocampal pyramidal CA1 cell loss, after 10 minutes of global cerebral ischemia. NBQX was given intraperitoneally in a do...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199209000-00016

    authors: Balchen T,Diemer NH

    更新日期:1992-09-01 00:00:00

  • Human CNTF and related cytokines: effects on DRG neurone survival.

    abstract::Ciliary neurotrophic factor (CNTF), leukaemia inhibitory factor (LIF), oncostatin M (OSM), interleukin-6 (IL-6), and interleukin-11 (IL-11) are structurally and functionally related cytokines. We compared their survival-promoting activities on embryonic chick and newborn rat dorsal root ganglion (DRG) neurones. Human ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:

    authors: Simon R,Thier M,Krüttgen A,Rose-John S,Weiergräber O,Heinrich PC,Schröder JM,Weis J

    更新日期:1995-12-29 00:00:00

  • Dopaminergic regulation of BDNF content in the pituitary intermediate lobe.

    abstract::Previous studies in adult rats have demonstrated that the neurotrophin, brain-derived neurotrophic factor (BDNF), is present in virtually all cells of the pituitary intermediate lobe. In the present study, we demonstrate that cells cultured from adult intermediate lobe pituitary (ILP) rapidly lose their BDNF immunorea...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199703240-00005

    authors: Höpker VH,Kjaer B,Varon S

    更新日期:1997-03-24 00:00:00

  • Eye-hand coordination in on-line visuomotor adjustments.

    abstract::When we perform a visually guided reaching action, the brain coordinates our hand and eye movements. Eye-hand coordination has been examined widely, but it remains unclear whether the hand and eye motor systems are coordinated during on-line visuomotor adjustments induced by a target jump during a reaching movement. A...

    journal_title:Neuroreport

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/WNR.0000000000000111

    authors: Abekawa N,Inui T,Gomi H

    更新日期:2014-05-07 00:00:00

  • Long-term sound conditioning increases distortion product otoacoustic emission amplitudes and decreases olivocochlear efferent reflex strength.

    abstract::The cochlea can be protected from acoustic trauma by moderate-level sound exposure. It is suggested that olivocochlear system may play a significant role in this protection. This study was performed to investigate distortion product otoacoustic emission (DPOAE) amplitudes changes and the efficiency of contralateral no...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32820049a8

    authors: Peng JH,Tao ZZ,Huang ZW

    更新日期:2007-07-16 00:00:00

  • Electrophysiological evidence of encoding in self-referential effect.

    abstract::Although the self-referential effect was widely supported by several previous studies, there was few event-related potential (ERP) evidence for the encoding mechanism of the self-referential effect. The present study employed ERPs to investigate whether the electrophysiological indices of the encoding processing could...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001303

    authors: Yang X,Mao X,Han M,Li X,Guo C

    更新日期:2019-09-04 00:00:00

  • Motor execution and imagination networks in post-stroke dystonia.

    abstract::Reorganization of motor execution and imagination networks was studied in six patients with unilateral dystonia secondary to a subcortical stroke and compared with seven control subjects using fMRI. Patients performed imagined and real auditory-cued hand movements. Movements of the dystonic hand resulted in overactivi...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200408260-00010

    authors: Lehéricy S,Gerardin E,Poline JB,Meunier S,Van de Moortele PF,Le Bihan D,Vidailhet M

    更新日期:2004-08-26 00:00:00

  • The role of transient receptor potential vanilloid receptor 1 and peroxisome proliferator-activated receptors-α in mediating the antinociceptive effects of palmitoylethanolamine in rats.

    abstract::Palmitoylethanolamine (PEA) is a ligand at peroxisome proliferator-activated receptors-α (PPARα), a nuclear receptor that has anti-inflammatory effects. Herein, complete Freund's adjuvant (CFA)-induced inflammatory pain model in rats and in-vitro calcium imaging studies were used to evaluate the mechanisms that underl...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001161

    authors: Aldossary SA,Alsalem M,Kalbouneh H,Haddad M,Azab B,Al-Shboul O,Mustafa AG,Obiedat S,El-Salem K

    更新日期:2019-01-02 00:00:00

  • Change of vanilloid receptor 1 expression in dorsal root ganglion and spinal dorsal horn during inflammatory nociception induced by complete Freund's adjuvant in rats.

    abstract::The present study aimed to systematically observe the change of vanilloid receptor 1 (VR1) during inflammatory nociception induced by intraplantar injection of complete Freund's adjuvant (CFA) into the left hind paw in rats. Hot plate latency (HPL) was used to evaluate resulting thermal hyperalgesia and immunohistoche...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200403220-00016

    authors: Luo H,Cheng J,Han JS,Wan Y

    更新日期:2004-03-22 00:00:00

  • Expression of the neurofibromatosis 1 (NF1) gene in reactive astrocytes in vitro.

    abstract::Neurofibromin, the product of the neurofibromatosis 1 (NF1) gene, is an important tumor suppressor protein expressed most abundantly in the nervous system. Within the central nervous system, neurofibromin has been localized to neurons and oligodendrocytes but not astrocytes. As individuals with NF1 are at an increased...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199507310-00025

    authors: Hewett SJ,Choi DW,Gutmann DH

    更新日期:1995-07-31 00:00:00

  • Evaluation of apparent diffusion coefficient measurements of brain injury in type 2 diabetics with retinopathy by diffusion-weighted MRI at 3.0 T.

    abstract::Diabetes is often associated with impairments in brain functioning. However, the injury of specific functioning areas of the brain is not clear. To address this problem, the present study was designed to investigate possible brain functioning change in specific brain areas, particularly in areas associated with vision...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000703

    authors: Wang Z,Lu Z,Li J,Pan C,Jia Z,Chen H,Ge X

    更新日期:2017-01-18 00:00:00

  • Nrsf silencing induces molecular and subcellular changes linked to neuronal plasticity.

    abstract::Neurite outgrowth involves various molecular mechanisms generating complex brain connections. These mechanisms have been linked to plasticity and learning and are thought to be deregulated in neuropsychiatric diseases. The transcription factor REST/NRSF regulates a subset of genes encoding neurite outgrowth molecules....

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e328011dc81

    authors: Lepagnol-Bestel AM,Maussion G,Ramoz N,Moalic JM,Gorwood P,Simonneau M

    更新日期:2007-03-26 00:00:00

  • Interleukin-1ra inhibits Fos expression and hyperalgesia in rats.

    abstract::It is known that interleukin-1beta facilitates pain, but the mechanisms of this are not understood. This study investigated the role of interleukin-1beta in the expression of Fos, a marker of neuronal activation, and hyperalgesia caused by injecting complete Freund's adjuvant into one hind paw of the rat. Interleukin-...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3280586839

    authors: Li A,Lao L,Wang Y,Zhang H,Ren K,Berman BM,Zhang R

    更新日期:2007-03-26 00:00:00

  • Simultaneous bilateral mismatch response to right- but not leftward sound lateralization.

    abstract::Magnetoencephalography (MEG) was used to compare mismatch responses between hemispheres to changes in sound-source direction. Sixteen adults listened passively to two types of complex non-language sounds presented in separate blocks with midline standards and right- and left-lateralized deviants. Mismatch dipole ampli...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200009110-00012

    authors: Kaiser J,Lutzenberger W,Birbaumer N

    更新日期:2000-09-11 00:00:00

  • Amyloid beta-peptide spin trapping. I: Peptide enzyme toxicity is related to free radical spin trap reactivity.

    abstract::Synthetic beta-amyloid peptides (A betas) demonstrate lot-to-lot variation in toxicity that has not been adequately explained. Studies from our laboratory have shown that A beta toxicity may result from the ability of the peptide to promote oxidation reactions. Both A beta(1-40) and A beta(25-35) inactivate the oxidat...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:

    authors: Hensley K,Aksenova M,Carney JM,Harris M,Butterfield DA

    更新日期:1995-02-15 00:00:00

  • Effects of diazepam and D-amphetamine on rhythmic pattern of eye movements in goldfish.

    abstract::The effects of diazepam and D-amphetamine on spontaneous, vestibular- and visually-induced eye movements were studied in the restrained goldfish. These animals showed a stereotyped pattern of spontaneous eye movements that scanned the visual field in the horizontal plane. Fourier analysis of these eye movements reveal...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199202000-00002

    authors: Salas C,Navarro F,Torres B,Delgado-Garcia JM

    更新日期:1992-02-01 00:00:00

  • Component-dependent urine responses in the rat accessory olfactory bulb.

    abstract::To investigate how pheromonal information is processed in the rat accessory olfactory bulb, we optically imaged intrinsic signals to obtain high-resolution maps of activation induced by urinary stimulation. Application of volatile components in male urine mainly induced activation in the anterior accessory olfactory b...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000239950.14954.59

    authors: Sugai T,Yoshimura H,Kato N,Onoda N

    更新日期:2006-11-06 00:00:00

  • Brightening prospects for early cortical coding of perceived luminance: a high-density electrical mapping study.

    abstract::Establishing the computational rules and neural substrates of brightness coding is a topic of both historical and contemporary interest. Two major classes of explanations for brightness illusions, such as brightness contrast, can be traced to Hering and Helmholtz. Hering's legacy is a low-level account in which bright...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200401190-00011

    authors: McCourt ME,Foxe JJ

    更新日期:2004-01-19 00:00:00

  • Influences of encoding and retrieval on the steady-state visual evoked potential.

    abstract::The steady-state visual evoked potential (SSVEP) is a powerful tool to study basic perceptual functions in the human electroencephalogram (EEG) (e.g. selective attention). The present study aimed at finding support for the SSVEP's sensitivity to higher cognitive functions (e.g. memory). We tagged pictures of meaningle...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3283516542

    authors: Martens U,Gert AL,Gruber T

    更新日期:2012-04-18 00:00:00

  • Cortical categorization failure in 2-month-old infants at risk for dyslexia.

    abstract::Cortical auditory categorization was assessed in 2-month-old infants at genetic risk for dyslexia and controls. Manipulated /bAk/ and /dAk/ speech stimuli were used as frequently presented standards. The neuroelectric brain responses of the control infants were highly sensitive to the phoneme boundary that separated t...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3280c1e2bf

    authors: van Leeuwen T,Been P,van Herten M,Zwarts F,Maassen B,van der Leij A

    更新日期:2007-06-11 00:00:00

  • Assessing cerebral representations of short and long vowel categories by NIRS.

    abstract::The present study examined cerebral representations of Japanese long and short vowel categories with near-infrared spectroscopy (NIRS) by measuring the hemodynamic changes. Results showed that NIRS could capture phoneme-specific information. The left side of the auditory area showed large hemodynamic changes only for ...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00001756-200204160-00009

    authors: Minagawa-Kawai Y,Mori K,Furuya I,Hayashi R,Sato Y

    更新日期:2002-04-16 00:00:00

  • Nitric oxide regulates NMDA-induced dopamine release in rat striatum.

    abstract::We investigated the effect of nitric oxide (NO) on N-methyl-D-aspartate (NMDA)-induced changes in levels of dopamine (DA) and its metabolite in the striatum using in vivo microdialysis. Local administration of 1mM NMDA into the striatum significantly augmented DA release in the striatum. Simultaneous administration of...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199601310-00055

    authors: Shibata M,Araki N,Ohta K,Hamada J,Shimazu K,Fukuuchi Y

    更新日期:1996-01-31 00:00:00

  • L-dopa increases nigral production of hydroxyl radicals in vivo: potential L-dopa toxicity?

    abstract::Dopamine (DA) deficiency in Parkinson's disease is commonly treated with L-dihydroxyphenylalanine (L-dopa), the amino acid precursor to DA. L-dopa is neurotoxic in vitro and impairs survival of metabolically stressed neurons in vivo. We examined with microdialysis of substantia nigra in awake rats the local production...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199404000-00039

    authors: Smith TS,Parker WD Jr,Bennett JP Jr

    更新日期:1994-04-14 00:00:00

  • Emotional appraisal processing of computer-generated facial expressions: an functional near-infrared spectroscopy study.

    abstract:OBJECTIVE:The current study aims to investigate whether computer generated (CG) expressions of emotion evoke similar emotional appraisal processing in the lateral orbitofrontal cortex (lOFC) compared to real human expressions, as well as how speech cues would influence the processing. METHODS:Functional near-infrared ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001420

    authors: Zhao T,Chen J,Wang L,Yan N

    更新日期:2020-04-08 00:00:00

  • Laminar-selective noradrenergic and serotoninergic modulation includes spinoparabrachial cells after inflammation.

    abstract::We evaluated the effects of chemical lesions on hindpaw inflammation-induced Fos protein expression in spinoparabrachial neurons that were retrogradely labeled by Fluoro-Gold. The descending serotoninergic and noradrenergic pathways were destroyed by the selective neurotoxins, 5,7-DHT and DSP-4, respectively. After 5,...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199906030-00024

    authors: Wei F,Dubner R,Ren K

    更新日期:1999-06-03 00:00:00

  • Astrocytes synthesize and secrete the lipophilic ligand carrier apolipoprotein D.

    abstract::Expression of the lipophilic ligand transporter, apolipoprotein D (apoD) by primary astrocyte cultures derived from neonatal mouse brain was investigated. Western blot analysis of cell lysates and media showed that apoD is constitutively secreted by astrocytes with little intracellular storage. The secreted apoD float...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199503000-00017

    authors: Patel SC,Asotra K,Patel YC,McConathy WJ,Patel RC,Suresh S

    更新日期:1995-03-07 00:00:00

  • Forebrain activation induced by postoral nutritive substances in rats.

    abstract::Recent studies have shown the nutrient-sensing systems transmitting nutritive information from the gut to the brain. However neural activity evoked by ingested dietary nutrients has not been investigated adequately. Using functional magnetic resonance imaging, we demonstrated that rat forebrain responded to intragastr...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e328307c414

    authors: Tsurugizawa T,Kondoh T,Torii K

    更新日期:2008-07-16 00:00:00

  • Neural discharge coupled to saccade offset in the cat visual cortex.

    abstract::The increase in neural activity in cat visual cortex associated with eye movements has been thought to reflect a replica of the motor command signal. We examined the timing of the saccade-related increase in neural activity in cat areas 17 and 18 in relation to saccade onset and offset. The increase in activity was te...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200006050-00013

    authors: Park J,Lee C

    更新日期:2000-06-05 00:00:00

  • A simulated actuator driven by motor cortical signals.

    abstract::One problem in motor control concerns the mechanism whereby the central nervous system translates the motor cortical command encoded in cell activity into a coordinated contraction of limb muscles to generate a desired motor output. This problem is closely related to the design of adaptive systems that transform neuro...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199611040-00038

    authors: Lukashin AV,Amirikian BR,Georgopoulos AP

    更新日期:1996-11-04 00:00:00

  • Eye instability induced by vestibular stimulation in rabbits.

    abstract::The slow compensatory phases of the vestibulo-ocular reflex (VOR) in the rabbit tend to drift and the drift reverses the direction. This periodic alternating drift (PAD) has two peculiar characteristics: (1) it is induced by sinusoidal vestibular stimulation in naive animals, being evoked immediately after stimulus on...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200107030-00017

    authors: Ferraresi A,Azzena GB,Troiani D

    更新日期:2001-07-03 00:00:00