Implication of non-NMDA and NMDA receptors in cochlear ischemia.

abstract：OBJECTIVE:The traditional Chinese medicine, Dendrobium nobile Lindl. polysaccharides (DNLP), reportedly has neuroprotective effects. However, its effects following ischemic stroke remain unclear. This study aimed to explore the role and mechanism of DNLP in experimental models of inflammation and apoptosis. METHODS:In...

journal_title：Neuroreport

authors： Liu J,Han Y,Zhu T,Yang Q,Wang H,Zhang H

更新日期：2020-12-14 00:00:00

abstract：:Serotonin (5-HT) is known to reduce apoptosis and in rodent models of brain ischemia. Modulation of programmed cell death during neural development was assessed in early postnatal brains of serotonin transporter (5-HTT) knockout mice, characterized by elevated extracellular 5-HT levels. The number of apoptotic cells v...

journal_title：Neuroreport

authors： Persico AM,Baldi A,Dell'Acqua ML,Moessner R,Murphy DL,Lesch KP,Keller F

更新日期：2003-03-03 00:00:00

abstract：:Cholinergic basal forebrain neurons (CBFN) expressing the low-affinity neurotrophin receptor p75 (p75(NTR)) were previously selectively labeled in vivo with carbocyanine 3 (Cy3)-tagged anti-p75(NTR), but the applied 192IgG-conjugates recognized p75(NTR) only in rat. The antibody ME 20.4 raised against human p75(NTR) h...

journal_title：Neuroreport

authors： Härtig W,Varga C,Kacza J,Grosche J,Seeger J,Luiten PG,Brauer K,Harkany T

更新日期：2002-08-07 00:00:00

abstract：:Cells overexpressing the beta-amyloid precursor protein possessing a mutation found in familial Alzheimer's disease overproduce beta-amyloid peptide (A beta). Because these findings were based on immunological identification, we have chemically characterized the peptides produced. Purified A beta fragments from the co...

journal_title：Neuroreport

authors： Dovey HF,Suomensaari-Chrysler S,Lieberburg I,Sinha S,Keim PS

更新日期：1993-08-01 00:00:00

abstract：:Anterior cingulate integrity may be required for antidepressant response. To assess anterior cingulate processes related to treatment response, we studied error-related negativity and error positivity produced during an emotional go/no-go challenge, a task activating the rostral anterior cingulate. Twelve elderly pati...

journal_title：Neuroreport

authors： Alexopoulos GS,Murphy CF,Gunning-Dixon FM,Kalayam B,Katz R,Kanellopoulos D,Etwaroo GR,Klimstra S,Foxe JJ

更新日期：2007-02-12 00:00:00

abstract：:Leptin in the rat's nucleus accumbens (NAcc) core has previously shown to disrupt the effects of acute administration of cocaine on both locomotor activity and the phosphorylation levels of glycogen synthase kinase 3β. In the present study, we further measured the phosphorylation levels of GluA1 after bilateral microi...

journal_title：Neuroreport

authors： Lee JW,Kim WY,Kim JH

更新日期：2018-04-11 00:00:00

abstract：:One approach to understanding the function of presenilin 1 (PS1), is to discover those proteins with which it interacts. Evidence for a function in developmental patterning came from C. elegans, in which a PS homologue was identified by screening for suppressors of a mutation in Notch/lin-12, a gene which specifies ce...

journal_title：Neuroreport

authors： Zhou J,Liyanage U,Medina M,Ho C,Simmons AD,Lovett M,Kosik KS

更新日期：1997-04-14 00:00:00

abstract：:To test the hypothesis that correlated neuronal activity serves as the neuronal code for visual feature binding, we applied information theory techniques to multiunit activity recorded from pairs of V1 recording sites in anaesthetised cats while presenting either single or separate bar stimuli. We quantified the roles...

journal_title：Neuroreport

authors： Golledge HD,Panzeri S,Zheng F,Pola G,Scannell JW,Giannikopoulos DV,Mason RJ,Tovée MJ,Young MP

更新日期：2003-05-23 00:00:00

abstract：:Impaired print tuning in dyslexia has been shown in alphabetic languages; whether we can observe the same in a nonalphabetic language such as Chinese is still questionable. The present study investigated the N170 component in response to Chinese words versus nonword pseudo-words in 10-year-old children with developmen...

journal_title：Neuroreport

authors： Zhou L,Yan X

更新日期：2018-10-17 00:00:00

abstract：:The effects of huperzine A on memory impairments induced by scopolamine were evaluated using a radial maze task and inhibition of cholinesterase in vitro compared with the effects of E2020 and tacrine. Scopolamine (0.2 mg kg-1) significantly impaired spatial memory in rats. Huperzine A (0.1-0.4 mg kg-1, p.o.), E2020 (...

journal_title：Neuroreport

authors： Cheng DH,Ren H,Tang XC

更新日期：1996-12-20 00:00:00

abstract：:Decisions made on the basis of risk often require rapid evaluation of feedback before follow-up actions and feedback-related negativity in brain potential is sensitive to the poor outcome. The current study investigated the effects of feedback from one's own decision (Experiment 1) and feedback from observing others' ...

journal_title：Neuroreport

authors： Liu Y,Dou K,Wang Y,Li J

更新日期：2015-11-11 00:00:00

abstract：:Schwann cells at the somatic neuromuscular junction possess adenosine receptors that when activated by the release of endogenous transmitter modulate quantal transmitter release. Recently, purinergic receptors have been shown to exist on Schwann cells of axon varicosities in visceral smooth muscle where they are activ...

journal_title：Neuroreport

authors： Lin YQ,Bennett MR

更新日期：2006-04-03 00:00:00

abstract：:Cisplatin is a widely used chemotherapeutic drug, but one of its side effects is ototoxicity. Epigenetic-related drugs, such as lysine-specific demethylase 1 (LSD1) inhibitors, have been reported to protect against cisplatin-induced hair cell loss by preventing demethylation of histone H3K4 (H3K4me2). However, the pro...

journal_title：Neuroreport

authors： Li A,He Y,Sun S,Cai C,Li H

更新日期：2015-06-17 00:00:00

abstract：:We investigated the effect of previous musical training on lateralization of language as indexed by the effects of reading aloud on the modulation of motor evoked potentials (MEPs) induced in the first dorsal interosseus muscles (FDI) by transcranial magnetic stimulation (TMS) of the primary motor cortex. We studied 1...

journal_title：Neuroreport

authors： Lin KL,Kobayashi M,Pascual-Leone A

更新日期：2002-05-07 00:00:00

abstract：:Presenilin-1 (PS-1) and amyloid precursor protein (APP) have been linked to the pathogenesis of Alzheimer's disease. While APP accumulation is well documented in several models of brain injury, the role of PS-1 levels in neurodegeneration, if any, remains to be elucidated. The current studies examined PS-1 and APP exp...

journal_title：Neuroreport

authors： Calingasan NY,Gandy SE,Gibson GE

更新日期：1997-07-28 00:00:00

abstract：:The pathogenesis of amyotrophic lateral sclerosis remains poorly understood, but microglial and astroglial activation are thought to contribute to motor neuron death. Evidence suggests that matrix metalloproteinase-9 (MMP-9) is a mediator of this deleterious effect. In this study, we evaluated the effect of MMP-9 on t...

journal_title：Neuroreport

authors： Dewil M,Schurmans C,Starckx S,Opdenakker G,Van Den Bosch L,Robberecht W

更新日期：2005-03-15 00:00:00

abstract：:This study aimed to investigate effects of observing the own body being touched on the functional topography of the somatosensory homunculus. We used neuromagnetic source imaging to map the topography in primary somatosensory cortex (SI) while manipulating the visibility of a touched hand. Participants were either abl...

journal_title：Neuroreport

authors： Schaefer M,Heinze HJ,Rotte M

更新日期：2008-06-11 00:00:00

abstract：:To define the significance of glutamate ionotropic receptors in sPLA -mediated neuronal cell death we used the NMDA receptor antagonist MK-801 and the AMPA receptor antagonist PNQX. In primary neuronal cell cultures both MK-801 and PNQX inhibited sPLA - and glutamate-induced neuronal death. [ H]Arachidonic acid releas...

journal_title：Neuroreport

authors： Kolko M,de Turco EB,Diemer NH,Bazan NG

更新日期：2002-10-28 00:00:00

abstract：:After amputation of an arm the sensory map of the body changes radically, causing the sensory input from face to 'invade' the original hand area in the brain. As a result, touching the face of the amputee evokes tactile sensations on the phantom. These sensory referrals from the face to phantom hand occur in a stable,...

journal_title：Neuroreport

authors： Ramachandran VS,Brang D,McGeoch PD

更新日期：2010-07-14 00:00:00

abstract：:In order to investigate GABA uptake into Müller glial cells electrophysiologically, we used the whole-cell voltage-clamp technique. Since Müller cells were insensitive to application of muscimol and baclofen, the expression of GABAA and GABAB receptors can be excluded. Therefore, the observed GABA current must be due ...

journal_title：Neuroreport

authors： Biedermann B,Eberhardt W,Reichelt W

更新日期：1994-01-12 00:00:00

abstract：:Spatial cognition requires the integration of visual inputs with proprioceptive and vestibular information about the position of the eye, the head and the body. All these sources are used by the brain to produce multiple higher-order (e.g. egocentric) representations of space, subserving accurate spatial behaviour. Su...

journal_title：Neuroreport

authors： Pizzamiglio L,Vallar G,Doricchi F

更新日期：1995-12-29 00:00:00

abstract：:Mammals react to acute hypoxia with an initial augmentation and a secondary depression of the respiratory rhythm generated by brain stem neuronal networks. To investigate the cytosolic level of energy rich phosphorus metabolites during these responses, we developed 31P nuclear magnetic resonance spectroscopy of the br...

journal_title：Neuroreport

authors： Piérard C,Champagnat J,Denavit-Saubie M,Gillet B,Beloeil JC,Guezennec CY,Barrère B,Pérès M

更新日期：1995-12-29 00:00:00

abstract：:Ts65DN mice were developed as a model of Down syndrome (DS); they are trisomic for the distal segment of chromosome 16 (MMU16), which contains genes syntenic with some of the genes located on the critical region of human chromosome 21 (HSA21). Since behavioral and neurochemical disturbances have been observed in this ...

journal_title：Neuroreport

authors： Megías M,Verduga R,Dierssen M,Flórez J,Insausti R,Crespo D

更新日期：1997-11-10 00:00:00

abstract：:Hypoxia-inducible factor-1 (HIF-1) regulates the expression of neuroprotective genes such as erythropoietin (EPO). We investigated the mechanism by which zinc, an excitotoxin-like metal, regulates HIF-1 under hypoxic conditions in astrocytes. In hypoxic LN215 cells, HIF-1alpha stabilized and accumulated in the nucleus...

journal_title：Neuroreport

authors： Kim I,Kim CH,Seo GH,Kim HS,Lee J,Kim DG,Ahn YS

更新日期：2008-07-02 00:00:00

abstract：:The mesocorticolimbic circuit projects to the prefrontal cortex, hippocampus, amygdala, and nucleus accumbens, among others, and it originates in the dopaminergic neurons of the ventral tegmental area (VTA). The VTA receives glutamatergic inputs from the prefrontal cortex and several subcortical regions. The glutamate...

journal_title：Neuroreport

authors： Ferrada C,Sotomayor-Zárate R,Abarca J,Gysling K

更新日期：2017-01-01 00:00:00

abstract：:We investigated the effects of chemical hypoxia on the central pattern generator controlling swimming in stage 42 Xenopus laevis larvae. We recorded motoneuron activity from ventral roots of immobilized tadpoles and evoked swim episodes by brief electrical stimulation of the tail skin. In the presence of the metabolic...

journal_title：Neuroreport

authors： Robertson RM,Björnfors ER,Sillar KT

更新日期：2010-10-06 00:00:00

abstract：:Topiramate is a structurally novel neurotherapeutic agent with a unique combination of pharmacological properties and currently is available in most world markets for treating several seizure disorders. Because its pharmacological profile was suggestive of possible activity as a neuroprotectant, topiramate was evaluat...

journal_title：Neuroreport

authors： Smith-Swintosky VL,Zhao B,Shank RP,Plata-Salaman CR

更新日期：2001-04-17 00:00:00

abstract：:Inconsistencies in previous attempts to localize the N2 wave in the GO/NOGO task led to the present investigation. The inconsistencies were probably because of heterogeneity of psychological operations involved in GO/NOGO tasks. We applied the independent component analysis to a collection of individual event-related ...

journal_title：Neuroreport

authors： Kropotov JD,Ponomarev VA

更新日期：2009-12-09 00:00:00

abstract：:The hippocampus is well known to contribute to episodic memory encoding. Here we used functional magnetic resonance imaging to investigate the hippocampal response to exponentially varying encoding demands while forming associations between faces and names. We found that only the left hippocampus exhibited a stepped m...

journal_title：Neuroreport

authors： Ulrich M,Jonas C,Grön G

更新日期：2010-01-06 00:00:00

abstract：:A unilateral ibotenic acid lesion of the nucleus basalis magnocellularis in the rat, which is known to produce a reduction in cortical choline acetyltransferase activity and acetylcholine release, produces a decrease of 125I-alpha-bungarotoxin and 125I-kappa-bungarotoxin binding sites in the frontoparietal cortex of t...

journal_title：Neuroreport

authors： Sugaya K,Downen M,Giacobini E

更新日期：1991-04-01 00:00:00