Abstract:
:Presenilin-1 (PS-1) and amyloid precursor protein (APP) have been linked to the pathogenesis of Alzheimer's disease. While APP accumulation is well documented in several models of brain injury, the role of PS-1 levels in neurodegeneration, if any, remains to be elucidated. The current studies examined PS-1 and APP expression in brain following thiamine deficiency (TD), a nutritional model associated with impaired oxidation and selective neurodegeneration. TD did not alter PS-1 immunoreactivity in any region of rodent brain before or after cell loss. In contrast, APP immunoreactivity accumulated in swollen neurites within, or around lesions in rats, or in abnormal clusters in mice. Thus, alterations in APP but not PS-1 levels are involved in TD-induced neurodegeneration.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Calingasan NY,Gandy SE,Gibson GEdoi
10.1097/00001756-199707280-00041subject
Has Abstractpub_date
1997-07-28 00:00:00pages
2631-4issue
11eissn
0959-4965issn
1473-558Xjournal_volume
8pub_type
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