Abstract:
:Antisera were produced against synthetic peptides predicted from the recent cloning of a delta opioid receptor, DOR-1. Confocal microscopic examination of immunostained spinal cord sections revealed that DOR-1 immunoreactive (-ir) nerve fibers and terminals form a moderately dense plexus within the superficial dorsal horn of rats and mice. These fibers decreased dramatically following dorsal rhizotomy and consistent with these observations a population of small diameter neurons in ganglia exhibited DOR-1-ir. DOR-1-ir ganglion neurons were also immunoreactive for calcitonin gene-related peptide (CGRP), and their terminals in the spinal cord contained both CGRP- and DOR-1-ir, the latter presumably located as a 'presynaptic' receptor. Interestingly, terminals containing DOR-1-ir appeared to be closely apposed by fibers and terminals containing enkephalin (ENK)-ir, which suggests that ENK may be a physiologically relevant ligand for the receptor encoded by DOR-1, and that DOR-1 may act to regulate the release of transmitters from small diameter primary afferent neurons.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Dado RJ,Law PY,Loh HH,Elde Rdoi
10.1097/00001756-199312000-00041subject
Has Abstractpub_date
1993-12-13 00:00:00pages
341-4issue
3eissn
0959-4965issn
1473-558Xjournal_volume
5pub_type
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