Abstract:
:The tetrodotoxin-resistant voltage-gated sodium channel Nav 1.8 is expressed only in nociceptive sensory neurons. This channel has been proposed to contribute significantly to the sensitization of primary sensory neurons after injury. We have studied the nociceptive behaviours of mice carrying a null mutation in the Nav 1.8 gene (Nav 1.8 -/-) in models of peripheral inflammation as well as a model of neuropathic pain. The results from the present studies reveal that Nav 1.8 is a necessary mediator of NGF-induced thermal hyperalgesia but is not essential for PGE2-evoked hypersensitivity. Neuropathic pain behaviours were unchanged in Nav 1.8 -/- mice indicating that this channel is not involved in the alteration of sensory thresholds following peripheral nerve injury.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Kerr BJ,Souslova V,McMahon SB,Wood JNdoi
10.1097/00001756-200110080-00019subject
Has Abstractpub_date
2001-10-08 00:00:00pages
3077-80issue
14eissn
0959-4965issn
1473-558Xjournal_volume
12pub_type
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