Abstract:
:In contrast to mechanisms mediating synaptic plasticity, the pharmacological basis of perceptual learning remains to be clarified. Here we report that a specific form of perceptual learning is influenced by GABAergic mechanisms. We induced perceptual learning by Hebbian co-activation of the skin of the tip of the right index fingers in human subjects. Under placebo conditions, tactile 2-point discrimination was improved on the co-activated, but not on the left, index finger. This augmentation was completely eliminated by lorazepam, a GABAA receptor agonist. No drug effects were found on the left index finger indicating that the drugs had no effect per se on performance. The results demonstrate that perceptual learning is subject to pharmacological gating by basic mechanisms known to mediate and modulate synaptic plasticity.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Dinse HR,Ragert P,Pleger B,Schwenkreis P,Tegenthoff Mdoi
10.1097/00001756-200309150-00018subject
Has Abstractpub_date
2003-09-15 00:00:00pages
1747-51issue
13eissn
0959-4965issn
1473-558Xjournal_volume
14pub_type
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