Restraint stress modulates glucocorticoid receptors and nuclear factor kappa B in the cochlea.


:The regulation of glucocorticoid receptors and nuclear factor kappaB was evaluated in the spiral ganglion neurons after 4 h of restraint stress in the mouse cochlea. Immediately after restraint stress, glucocorticoid receptor protein expression was not altered in spiral ganglion neurons even though both the plasma corticosterone levels and glucocorticoid receptor nuclear translocation increased. By 24 h after restraint stress, the protein expression of glucocorticoid receptors was decreased in spiral ganglion neurons. Pre-treatment with RU486 and metyrapone prevented nuclear translocation of glucocorticoid receptors and nuclear factor kappaB. Moreover, the synthesis of nuclear factor kappaB protein (p65) and inhibitory factor kappaBalpha decreased when RU486 and metyrapone treatment was given before restraint stress. These findings suggest that restraint stress modulates glucocorticoid receptor and nuclear factor kappaB activity in the spiral ganglion neurons, resulting in an altered response to stress.






Tahera Y,Meltser I,Johansson P,Canlon B




Has Abstract


2006-06-26 00:00:00














  • N400 amplitude does not recover from disappearance after repetitions despite reinitiated semantic integration difficulty.

    abstract::It remains an open question whether the amplitude of N400 reflects combinatory postlexical semantic integration processing. To examine the issue, we repeatedly presented strictly simplified, N400-eliciting three-word structures for seven times, mixed with their plausible counterparts, followed immediately by a much mo...


    pub_type: 杂志文章


    authors: Huang Y,Jiang M,Guo Q,Yang FG

    更新日期:2018-11-07 00:00:00

  • BDNF-mediated rescue of axotomized motor neurones decreases with increasing dose.

    abstract::Direct application of brain-derived neurotrophic factor (BDNF) to the cut end of axotomized immature motor neurones had only transient survival-promoting effects. Therefore, we have examined whether additional delivery of BDNF with repeated subcutaneous injections (1 mg/ml) could potentiate this short-term rescue of t...


    pub_type: 杂志文章


    authors: Vejsada R,Sagot Y,Kato AC

    更新日期:1994-10-03 00:00:00

  • The AMPA antagonist, NBQX, protects against ischemia-induced loss of cerebellar Purkinje cells.

    abstract::We examined the effect of an AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole) antagonist, 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo (F) quinoxaline (NBQX), on rat cerebellar Purkinje cell loss and hippocampal pyramidal CA1 cell loss, after 10 minutes of global cerebral ischemia. NBQX was given intraperitoneally in a do...


    pub_type: 杂志文章


    authors: Balchen T,Diemer NH

    更新日期:1992-09-01 00:00:00

  • Interocular suppression in cat striate cortex is not orientation selective.

    abstract::For the majority of neurones in cat striate cortex, the response to an optimal stimulus presented to one eye is suppressed when a stimulus of substantially different orientation is presented to the other eye. In order to determine the true orientational tuning of the underlying inhibitory interactions in the absence o...


    pub_type: 杂志文章


    authors: Sengpiel F,Freeman TC,Blakemore C

    更新日期:1995-11-13 00:00:00

  • Co-dergocrine (Hydergine) regulates striatal and hippocampal acetylcholine release through D2 receptors.

    abstract::The effect of Co-dergocrine (Hydergine) on acetylcholine (ACh) release in the striatum and hippocampus has been studied by means of brain microdialysis and compared to the effect of SKF 38393 and of LY 171555 selective D1 and D2 dopamine (DA) receptor agonists, respectively. Co-dergocrine (1 and 5 mg kg-1 i.p.) as wel...


    pub_type: 杂志文章


    authors: Imperato A,Obinu MC,Dazzi L,Carta G,Mascia MS,Casu MA,Gessa GL

    更新日期:1994-02-24 00:00:00

  • Increased levels of TrkA in the regenerating retinal ganglion cells of fish.

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    pub_type: 杂志文章


    authors: Vecino E,Caminos E,Becker E,Rudkin BB,Evan GI,Martín-Zanca D

    更新日期:1998-10-26 00:00:00

  • Down-regulation of p27kip1 increases proliferation of progenitor cells in adult rats.

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    pub_type: 杂志文章


    authors: Zhang R,Zhang Z,Tsang W,Wang L,Chopp M

    更新日期:2004-08-06 00:00:00

  • An ignoring task improves validity of cortical evoked response audiometry.

    abstract::This study examined the basis for introducing an ignoring task during cortical evoked response audiometry (CERA) using the N1-P2 response. Healthy hearing participants were assigned to two groups with and without an ignoring task (ignoring and listening groups) during CERA whose outcomes were compared with the pure-to...


    pub_type: 杂志文章


    authors: Ikeda K,Hayashi A,Matsuda O,Sekiguchi T

    更新日期:2010-07-14 00:00:00

  • Epidermal growth factor receptor is involved in clusterin-induced astrocyte proliferation.

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    pub_type: 杂志文章


    authors: Shim YJ,Shin YJ,Jeong SY,Kang SW,Kim BM,Park IS,Min BH

    更新日期:2009-03-04 00:00:00

  • Brainstem microstimulation differentially inhibits pudendal motoneuron reflex inputs.

    abstract::Sensory information from the genitourinary tract is transmitted to perineal muscle reflex circuits in the spinal cord and to the medullary reticular formation (MRF). This is the first report of a functional descending connection between neurons in the MRF and sensory inputs of the pudendal motoneuron reflex circuitry....


    pub_type: 杂志文章


    authors: Johnson RD,Hubscher CH

    更新日期:1998-01-26 00:00:00

  • Inhibition of microRNA-429 attenuates oxygen-glucose deprivation/reoxygenation-induced neuronal injury by promoting expression of GATA-binding protein 4.

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    pub_type: 杂志文章


    authors: Xiao J,Kong R,Hu J

    更新日期:2018-06-13 00:00:00

  • Cocaine alters body temperature and behavioral thermoregulatory responses.

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    pub_type: 杂志文章


    authors: Gonzalez LP

    更新日期:1993-01-01 00:00:00

  • Distribution of Smoothened at hippocampal mossy fiber synapses.

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    pub_type: 杂志文章


    authors: Masdeu C,Bernard V,Faure H,Traiffort E,Ruat M

    更新日期:2007-03-05 00:00:00

  • No relation between 2D : 4D fetal testosterone marker and dyslexia.

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    pub_type: 杂志文章


    authors: Boets B,De Smedt B,Wouters J,Lemay K,Ghesquière P

    更新日期:2007-09-17 00:00:00

  • Identification of short latency auditory responsive neurons in the cat dentate nucleus.

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    pub_type: 杂志文章


    authors: Xi MC,Woody CD,Gruen E

    更新日期:1994-08-15 00:00:00

  • Caffeine elicits c-Fos expression in horizontal diagonal band cholinergic neurons.

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    pub_type: 杂志文章


    authors: Reznikov LR,Pasumarthi RK,Fadel JR

    更新日期:2009-12-09 00:00:00

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    pub_type: 杂志文章


    authors: Takigawa T,Yasuda H,Terada M,Maeda K,Haneda M,Kashiwagi A,Kitasato H,Kikkawa R

    更新日期:2000-08-03 00:00:00

  • Growth hormone-releasing peptide-6 inhibits cerebellar cell death in aged rats.

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    pub_type: 杂志文章


    authors: Pañeda C,Arroba AI,Frago LM,Holm AM,Rømer J,Argente J,Chowen JA

    更新日期:2003-08-26 00:00:00

  • Membrane-associated prostaglandin E synthase-1 is required for neuropathic pain.

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    pub_type: 杂志文章


    authors: Mabuchi T,Kojima H,Abe T,Takagi K,Sakurai M,Ohmiya Y,Uematsu S,Akira S,Watanabe K,Ito S

    更新日期:2004-06-28 00:00:00

  • Context-dependent representation of reinforcement in monkey amygdala.

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    pub_type: 杂志文章


    authors: Hirai D,Hosokawa T,Inoue M,Miyachi S,Mikami A

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  • Dexamethasone blocks astroglial differentiation from neural precursor cells.

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    pub_type: 杂志文章


    authors: Sabolek M,Herborg A,Schwarz J,Storch A

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  • Postural effects of motion vision in young autistic children.

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    pub_type: 杂志文章


    authors: Gepner B,Mestre D,Masson G,de Schonen S

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  • Simultaneous spike detection and topographic classification in pediatric surface EEGs.

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    pub_type: 杂志文章


    authors: Feucht M,Hoffmann K,Steinberger K,Witte H,Benninger F,Arnold M,Doering A

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    pub_type: 杂志文章


    authors: Dekkers J,Navarrete R

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    authors: Schindler M,Holloway S,Humphrey PP,Waldvogel H,Faull RL,Berger W,Emson PC

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  • Hypoxia suppresses kainate-induced gamma-oscillations in rat hippocampal slices.

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    pub_type: 杂志文章


    authors: Fano S,Behrens CJ,Heinemann U

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    pub_type: 杂志文章


    authors: Killgore WD,Kipman M,Schwab ZJ,Tkachenko O,Preer L,Gogel H,Bark JS,Mundy EA,Olson EA,Weber M

    更新日期:2013-12-04 00:00:00

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    pub_type: 杂志文章


    authors: Staunton M,Dulitz MG,Fang C,Schmeling WT,Kampine JP,Farber NE

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    authors: Lu S,Song L,Wang D,Zhang X,Lv X,Yin H,Gao Y,Liu X,Tang J

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    pub_type: 杂志文章


    authors: Shin HK,Kim JH

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