Abstract:
:The regulation of glucocorticoid receptors and nuclear factor kappaB was evaluated in the spiral ganglion neurons after 4 h of restraint stress in the mouse cochlea. Immediately after restraint stress, glucocorticoid receptor protein expression was not altered in spiral ganglion neurons even though both the plasma corticosterone levels and glucocorticoid receptor nuclear translocation increased. By 24 h after restraint stress, the protein expression of glucocorticoid receptors was decreased in spiral ganglion neurons. Pre-treatment with RU486 and metyrapone prevented nuclear translocation of glucocorticoid receptors and nuclear factor kappaB. Moreover, the synthesis of nuclear factor kappaB protein (p65) and inhibitory factor kappaBalpha decreased when RU486 and metyrapone treatment was given before restraint stress. These findings suggest that restraint stress modulates glucocorticoid receptor and nuclear factor kappaB activity in the spiral ganglion neurons, resulting in an altered response to stress.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Tahera Y,Meltser I,Johansson P,Canlon Bdoi
10.1097/01.wnr.0000220131.24468.e7subject
Has Abstractpub_date
2006-06-26 00:00:00pages
879-82issue
9eissn
0959-4965issn
1473-558Xpii
00001756-200606260-00006journal_volume
17pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::Schwann cells at the somatic neuromuscular junction possess adenosine receptors that when activated by the release of endogenous transmitter modulate quantal transmitter release. Recently, purinergic receptors have been shown to exist on Schwann cells of axon varicosities in visceral smooth muscle where they are activ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000209001.09987.77
更新日期:2006-04-03 00:00:00
abstract::Neuregulins (NRG), the only trophic factors known to support Schwann cell survival, have a potential for use in treatment of patients with chronic neuropathies. Expression of one NRG isoform, NRG-beta1, was increased in axons in the early phase of axonal degeneration in nerve biopsy specimens from patients with neurop...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200011270-00017
更新日期:2000-11-27 00:00:00
abstract::Cell death and neurofibrillary tangle formation are prominent features of Alzheimer's disease (AD). It has been suggested that DNA damage may reflect neuronal vulnerability. In this context, the Ced homologue Bcl-2 is able to repress a number of cell death programs. Recently we found both numerous nuclei exhibiting DN...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199601310-00015
更新日期:1996-01-31 00:00:00
abstract::The major central nervous system (CNS) myelin proteolipid (PLP) is also expressed in the peripheral nervous system (PNS). This paper gives evidence that DM-20, an isoform of PLP, also occurs in rat sciatic nerves, where, in contrast to what is seen in CNS myelin, it predominates over PLP. This conclusion was reached o...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199102000-00006
更新日期:1991-02-01 00:00:00
abstract::Cortical auditory categorization was assessed in 2-month-old infants at genetic risk for dyslexia and controls. Manipulated /bAk/ and /dAk/ speech stimuli were used as frequently presented standards. The neuroelectric brain responses of the control infants were highly sensitive to the phoneme boundary that separated t...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3280c1e2bf
更新日期:2007-06-11 00:00:00
abstract::High homocysteine serum level has been regarded as one of the important factors that influence the development of schizophrenia. Genetic variations of methylenetetrahydrofolate reductase, which is a main enzyme reducing homocysteine level, are reported in schizophrenic patients. We measured the serum level of homocyst...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000215777.99473.52
更新日期:2006-05-15 00:00:00
abstract::The aim of this study was to examine the neurodegenerative effects of intraventricular colchicine on granule cells of the hippocampal dentate gyrus and to characterise the modality of neuronal cell death. Male Sprague-Dawley rats were killed 24 hours after a single injection of colchicine into the third ventricle and ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199712010-00025
更新日期:1997-12-01 00:00:00
abstract::beta-N-methylamino-L-alanine (L-BMAA) is an excitotoxin whose neurodegenerative effects are associated with its agonist properties at the N-methyl-D-aspartate (NMDA) receptor. We measured the effects of L-BMAA on inositol phosphate (InsP) formation in primary cultured striatal neurons. This culture is almost devoid of...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199110000-00014
更新日期:1991-10-01 00:00:00
abstract::A bilateral spino-bulbo-spinal circuit conveys information from/to the male urogenital tract and perineal muscles. This is the first electrophysiological report of another descending pathway, one which conveys output from the medullary reticular formation (MRF) to activate postganglionic sympathetic fibers contained w...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200002070-00031
更新日期:2000-02-07 00:00:00
abstract::The terrestrial snail Helix lucorum is a promising model for molecular neurobiology since its central nervous system (CNS) is simple and contains many morphologically and functionally identified large neurones. Among these, the giant interneurones located in pleural and parietal ganglia are especially interesting beca...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199401000-00014
更新日期:1994-01-31 00:00:00
abstract::To investigate the phonological influences on the lexicosemantic process with a strong orthographic constraint, we used kanji (morphogram) homophone words and measured, using magnetoencephalography, the neural activities during the silent reading of prime-target pairs. The primes were phonologically the same as or dif...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282f16ddf
更新日期:2007-11-19 00:00:00
abstract::Previous studies have shown that spatial memory retention is affected by the metabotropic glutamate receptor (mGluR) influencing agents (R,S)-alpha-methyl-4-carboxyphenylglycine (MCPG) and trans-azetidine-2,4-dicarboxylic acid (tADA). In the present investigation we examined whether the mGluR antagonist MCPG (20 mM an...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199511270-00027
更新日期:1995-11-27 00:00:00
abstract::We investigated the reactive cytoskeletal changes following physical damage to axons in the rodent neocortex and compared these with the earliest neuronal alterations seen in Alzheimer's disease (AD). Insertion of a 25 gauge needle into the rodent somatosensory cortex resulted in ring- and club-like axonal changes cha...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1997-05-06 00:00:00
abstract::Canine degenerative myelopathy (DM) is a fatal neurodegenerative disorder prevalent in the canine population. It may represent a unique, naturally occurring disease model for human amyotrophic lateral sclerosis (ALS) because of similar clinical signs and association with superoxide dismutase 1 gene (SOD1) mutations. M...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001151
更新日期:2019-01-02 00:00:00
abstract::Integrating information across the senses can enhance our ability to detect and classify stimuli in the environment. For example, auditory speech perception is substantially improved when the speaker's face is visible. In an fMRI study designed to investigate the neural mechanisms underlying these crossmodal behaviour...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199908200-00033
更新日期:1999-08-20 00:00:00
abstract::We investigated the effects of radio frequency electromagnetic fields on brain physiology. Twenty-four healthy young men were exposed for 30 min to pulse-modulated or continuous-wave radio frequency electromagnetic fields (900 MHz; peak specific absorption rate 1 W/kg), or sham exposed. During exposure, participants p...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/WNR.0b013e3280d9435e
更新日期:2007-05-28 00:00:00
abstract::The most important risk factor for developing Parkinson's disease (PD) is age. Aging is ascribed to different mechanisms, including telomere shortening. Telomeres consist of repetitive DNA sequences and stabilize chromosome integrity. Currently, however, the data reported on telomere shortening in PD patients are inco...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000099
更新日期:2014-03-26 00:00:00
abstract::Frontolimbic structures involved in fear conditioning have also been associated with hypothalamic-pituitary-adrenal (HPA)-axis modulation, including amygdaloid, hippocampal, and ventromedial prefrontal cortex regions. Although HPA-axis function and endocrine changes have been investigated in the context of stress prov...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328326a031
更新日期:2009-03-04 00:00:00
abstract::Voltage-gated K+ channels (K(V)) regulate cell electrical properties, proliferation, migration, and death. Rotenone is a mitochondrial inhibitor, influencing activity of many channels that potentially participate in cell death processes, but its effect on K(V) channel in neurons remains unclear. This study used whole-...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32830d149e
更新日期:2008-09-17 00:00:00
abstract::Plasminogen activators (PAs) have been suggested to play a role in neuronal migration and glial cell proliferation in the developing CNS. Less is known, however, about the role of PAs in the mature nervous system. To elucidate the role of tissue type plasminogen activator (tPA) in the nervous system we used in situ hy...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199701200-00008
更新日期:1997-01-20 00:00:00
abstract::Dopaminergic neurotransmission is thought to be involved in reward-related incentive learning and addictive behaviour. Amphetamine will alter glycogen synthase kinase-3β (GSK-3β) activity by increasing dopamine transporter efflux rates. We investigated the hypothesis that Wnt signalling will be altered in rat nucleus ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328357d868
更新日期:2012-10-03 00:00:00
abstract::Temporal changes of serotonin (5-HT) content in the median (MRN) and dorsal (DRN) raphe nuclei were measured in rats kept under various lighting conditions. Serotonin content in the MRN and DRN under light-dark (LD) condition showed diurnal rhythmicity, with a peak during early light phase and a trough during the dark...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199310000-00012
更新日期:1993-10-25 00:00:00
abstract::We studied the distribution of phosphorylated tau (p-tau) in neonatal and adult rat cerebrum using monoclonal antibodies that recognize distinct tau epitopes in a phosphorylation-dependent manner. In neonatal cortex, p-tau was detected in the apical dendrites and somata of pyramidal neurons as well as in axons. In adu...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199708180-00029
更新日期:1997-08-18 00:00:00
abstract::The changes of nitric oxide synthase (NOS) activity and nitrite level in rat brain regions after spatial learning were investigated. NOS activity was assayed by conversion of [3H]L-arginine to [3H]L-citrulline, and a sensitive fluorometric assay for quantification of nitrite was used. Compared with sham-trained rats, ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199705060-00040
更新日期:1997-05-06 00:00:00
abstract::We examined the effect of stimulus interruption on dual component field EPSPs in the hippocampal CA1 region. Resuming test stimulation at 0.1 Hz after 10-60 min silent periods led to an increase of the response followed by a decline, involving AMPA and NMDA components to a similar extent. Similar changes were seen whe...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199904060-00005
更新日期:1999-04-06 00:00:00
abstract::We used two developmental transcription factors, x-Eomes (T-box family) and x-Lhx5 (LIM-homeodomain family), to follow the origin and development of the olfactory bulbs in Xenopus. During embryonic and larval development, x-Eomes and x-Lhx5 were expressed in highly similar patterns, in the lateral and latero-ventral w...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200312190-00013
更新日期:2003-12-19 00:00:00
abstract::Mesencephalic astrocyte-derived neurotrophic factor (MANF) - one of a new class of astrocyte-derived human proteins--selectively promotes the survival of dopamine neurons of the ventral midbrain. Using the whole-cell clamp technique, we looked for acute effects of MANF on gamma-aminobutyric acid type A (GABAA) recepto...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000201504.23255.bc
更新日期:2006-02-27 00:00:00
abstract::Papaverine is a non-specific vasodilatory drug, which was found to unexpectedly cause opening of the blood-brain barrier (BBB). We studied the expression of two endothelial cell related markers, endothelial barrier antigen (EBA) as a marker of BBB intactness, and matrix metalloproteinase-9 (MMP-9), an extracellular ma...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200212030-00011
更新日期:2002-12-03 00:00:00
abstract::Self-renewing neural stem cells and progenitor cells are cell populations that generate radial glial cells and neurons through asymmetric division. Regulation of intracellular pH in stem cells with high metabolic activity is critical for both cell signaling and proliferation. We have recently found that a S0859-inhibi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001372
更新日期:2020-01-08 00:00:00
abstract::Target detection is the process of bringing a salient stimulus into conscious awareness. Target detection evokes a prominent event-related potential (ERP) component (P3) in the electroencephalogram (EEG). We combined the high spatial resolution of functional magnetic resonance imaging (fMRI) with the high temporal res...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00001756-199709290-00007
更新日期:1997-09-29 00:00:00